The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
DNA methylation: past, present and future directions
Abstract
DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development; however, its presence can add an additional burden to the genome. Normal methylation patterns are frequently disrupted in tumor cells with global hypomethylation accompanying region-specific hypermethylation. When these hypermethylation events occur within the promoter of a tumor suppressor gene they will silence the gene and provide the cell with a growth advantage in a manner akin to deletions or mutations. Recent work indicating that DNA methylation is an important player in both DNA repair and genome stability as well as the discovery of a new family of DNA methyltransferases makes now a very exciting period for the methylation field. This review will highlight the major findings in the methylation field over the past 20 years then summarize the most important and interesting future directions the field is likely to take in the next millennium.
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Cites
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Cited by
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
Rhee, I., Bachman, K. E., Park, B. H., Jair, K.-W., Yen, R.-W. C., Schuebel, K. E., Cui, H., Feinberg, A. P., Lengauer, C., Kinzler, K. W., et al. (2002) · Nature · doi:10.1038/416552a · Cited by 1,039
DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951
Takizawa, T., Nakashima, K., Namihira, M., Ochiai, W., Uemura, A., Yanagisawa, M., Fujita, N., Nakao, M., & Taga, T. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00101-0 · Cited by 608
The biology of the mammalian Krüppel-like family of transcription factors
Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458
Chemoprevention: an essential approach to controlling cancer
Sporn, M. B., & Suh, N. (2002) · Nature Reviews Cancer · doi:10.1038/nrc844 · Cited by 379
Metadata
- Authors
- Robertson, K. D., & A.Jones, P.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 21
- Issue
- 3
- Pages
- 461-467
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2051966279
- Cited by
- 607
- References
- 77
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- closed
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