Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
Open accessAbstract
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07-1.60] and in the high (RR = 1.41; 95% CI = 1.16-1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34-3.68). The strongest association was found for stomach cancer [RR(medium) = 1.17 (95% CI = 0.37-3.70), RR(high) = 3.13 (95% CI = 1.17-8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.
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Lymphocyte dicentrics are considered among the best biomarkers of normal tissue damage risk.
“More recently, we have developed an analogous database to simulate dicentric dose-response in human lymphocytes, which are considered among the best biomarkers of normal tissue damage risk [See, e.g. 2, 8, 18 -20].”
From Radiobiological damage by space radiation: extension of the BIANCA model to heavy ions up to iron, and pilot application to cosmic ray exposure (2022) · cites this paper as [19]
The Introduction and Discussion describe chromosomal aberrations in lymphocytes as biomarkers of cancer risk. The Results include dicentrics among the aberrations studied, but report a non-significant association for them; the paper does not identify dicentrics as among the best biomarkers of normal tissue damage risk. (LLM, conf=0.84)
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- Authors
- Bonassi, S., Norppa, H., Ceppi, M., Stromberg, U., Vermeulen, R., Znaor, A., Cebulska-Wasilewska, A., Fabianova, E., Fucic, A., Gundy, S., Hansteen, I.-L., Knudsen, L. E., Lazutka, J., Rossner, P., Sram, R. J., & Boffetta, P.
- Affiliations
- Finnish Institute of Occupational Health (FI)
- Utrecht University (NL)
- Hrvatski zavod za javno zdravstvo (HR)
- Institute of Nuclear Physics, Polish Academy of Sciences (PL)
- Public Health Authority of the Slovak Republic (SK)
- Institute for Medical Research and Occupational Health (HR)
- National Institute of Oncology (HU)
- Telemark Hospital (NO)
- University of Copenhagen (DK)
- Vilnius University (LT)
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Bonassi, S.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-15
- Volume
- 29
- Issue
- 6
- Pages
- 1178-1183
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- PMC
- PMC2443275
- OpenAlex
- W2106625186
- Cited by
- 336
- References
- 31
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 5 · 2023: 14 · 2022: 20 · 2021: 15 · 2020: 20 · 2019: 13 · 2018: 16 · 2017: 22 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 25 · 2012: 24
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Carcinogenesis (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Nordic Pharma Group
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- chromosomal abnormalities, peripheral blood lymphocytes, cancer risk prediction, ring chromosomes, chromosome-type aberrations, gastric cancer, carcinogen exposure, biomonitoring, cancer incidence, cancer mortality, pooled cohort analysis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Female, Humans, Lymphocytes, Male, Middle Aged, Neoplasms, Risk Factors, Cohort Studies, Incidence, Risk Assessment, Genetic Predisposition to Disease
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