Cited by 330Cancer Cells and MetastasisMesenchymal stem cell researchAngiogenesis and VEGF in Cancer

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Tissue-resident stem cells promote breast cancer growth and metastasis

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Muehlberg, Fabian L., Song, Yao-Hua, Krohn, Alexander, Pinilla, Severin P., Droll, Lilly H., Leng, Xiaohong, Seidensticker, Max, Ricke, Jens, Altman, Andrew M., Devarajan, Eswaran, Liu, Weili, Arlinghaus, Ralph B., Alt, Eckhard U.·2009·Carcinogenesis

DOI 10.1093/carcin/bgp036

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Abstract

Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma. In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) could play a role in tumor growth and invasion. Compared with bone marrow-derived cells, ASCs as tissue-resident stem cells are locally adjacent to breast cancer cells and may interact with tumor cells directly. Here, we demonstrate that ASCs cause the cancer to grow significantly faster when added to a murine breast cancer 4T1 cell line. We further show that breast cancer cells enhance the secretion of stromal cell-derived factor-1 from ASCs, which then acts in a paracrine fashion on the cancer cells to enhance their motility, invasion and metastasis. The tumor-promoting effect of ASCs was abolished by knockdown of the chemokine C-X-C receptor 4 in 4T1 tumor cells. We demonstrated that ASCs home to tumor site and promote tumor growth not only when co-injected locally but also when injected intravenously. Furthermore, we demonstrated that ASCs incorporate into tumor vessels and differentiate into endothelial cells. The tumor-promoting effect of tissue-resident stem cells was also tested and validated using a human breast cancer line MDA-MB-231 cells and human adipose tissue-derived stem cells. Our findings indicate that the interaction of local tissue-resident stem cells with tumor stem cells plays an important role in tumor growth and metastasis.

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Authors: Muehlberg, F. L., Song, Y.-H., Krohn, A., Pinilla, S. P., Droll, L. H., Leng, X., Seidensticker, M., Ricke, J., Altman, A. M., Devarajan, E., Liu, W., Arlinghaus, R. B., & Alt, E. U.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
University Hospital Magdeburg (DE)
Corresponding author: Alt, Eckhard U.
ORCID: Muehlberg, Fabian L.
Krohn, Alexander
Leng, Xiaohong
Seidensticker, Max
Ricke, Jens
Liu, Weili
Alt, Eckhard U.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2009-01-30
Volume: 30
Issue: 4
Pages: 589-597
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/bgp036
OpenAlex: W2107402669
Cited by: 330
References: 71
Citations by year: 2026: 2 · 2025: 5 · 2024: 13 · 2023: 9 · 2022: 11 · 2021: 19 · 2020: 10 · 2019: 17 · 2018: 18 · 2017: 13 · 2016: 20 · 2015: 33 · 2014: 35 · 2013: 24 · 2012: 31
FWCI: 16.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
BORIS (University Library Bern) (submittedVersion, other-oa)
Open Access CRIS of the University of Bern
Funders: U.S. Department of Defense (W81XWH, W81XWH0810523)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: tissue-resident stem cells, adipose-derived stem cells, breast cancer, tumor growth, metastasis, CXCL12, CXCR4, paracrine signaling, tumor cell motility, tumor invasion, stem cell homing, tumor vasculature, endothelial differentiation, tumor microenvironment, 4T1 cells, MDA-MB-231 cells
MeSH terms: Adipose Tissue, Animals, Cell Movement, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Lung Neoplasms, Male, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Neovascularization, Pathologic, Neoplastic Stem Cells, Blotting, Western, Mammary Neoplasms, Animal, Stromal Cells, Spheroids, Cellular, Receptors, CXCR4, Vascular Endothelial Growth Factor A, Immunoprecipitation, Mice, Chemokine CXCL12

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Tissue-resident stem cells promote breast cancer growth and metastasis

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