Cited by 330Cancer Cells and MetastasisMesenchymal stem cell researchAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 65 of the 71 references it cites were found in a registry or an index.

Tissue-resident stem cells promote breast cancer growth and metastasis

Open access

Muehlberg, Fabian L., Song, Yao-Hua, Krohn, Alexander, Pinilla, Severin P., Droll, Lilly H., Leng, Xiaohong, Seidensticker, Max, Ricke, Jens, Altman, Andrew M., Devarajan, Eswaran, Liu, Weili, Arlinghaus, Ralph B., Alt, Eckhard U.·2009·Carcinogenesis

DOI 10.1093/carcin/bgp036

Open this paper in CoChat — free account Open PDF

Abstract

Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma. In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) could play a role in tumor growth and invasion. Compared with bone marrow-derived cells, ASCs as tissue-resident stem cells are locally adjacent to breast cancer cells and may interact with tumor cells directly. Here, we demonstrate that ASCs cause the cancer to grow significantly faster when added to a murine breast cancer 4T1 cell line. We further show that breast cancer cells enhance the secretion of stromal cell-derived factor-1 from ASCs, which then acts in a paracrine fashion on the cancer cells to enhance their motility, invasion and metastasis. The tumor-promoting effect of ASCs was abolished by knockdown of the chemokine C-X-C receptor 4 in 4T1 tumor cells. We demonstrated that ASCs home to tumor site and promote tumor growth not only when co-injected locally but also when injected intravenously. Furthermore, we demonstrated that ASCs incorporate into tumor vessels and differentiate into endothelial cells. The tumor-promoting effect of tissue-resident stem cells was also tested and validated using a human breast cancer line MDA-MB-231 cells and human adipose tissue-derived stem cells. Our findings indicate that the interaction of local tissue-resident stem cells with tumor stem cells plays an important role in tumor growth and metastasis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/carcin/bgp036

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413
Stromal fibroblasts in cancer initiation and progression
Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004) · Nature · doi:10.1038/nature03096 · Cited by 2,354
Cancer and the chemokine network
Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343
Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties
Ponti, D., Costa, A., Zaffaroni, N., Pratesi, G., Petrangolini, G., Coradini, D., Pilotti, S., Pierotti, M. A., & Daidone, M. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0626 · Cited by 1,725
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Cunha, G., Hein, P., & Tlsty, T. (2000) · Breast Cancer Research · doi:10.1186/bcr138 · Cited by 1,463
Role of tissue stroma in cancer cell invasion
De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042

Flagged first, then by citations

Show all 71 references

6 of the 71 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Hsieh, 1999, Stem cell differentiation and reduction as a potential mechanism for chemoprevention of breast cancer, Chinese Pharm. J., 51, 15
Chang, 2000, Roles of ionizing radiation in neoplastic transformation of human breast epithelial cells, 576

Sorted by citations

Items 101–200 of 329

Characterization and comparison of telomere length, telomerase and reverse transcriptase activity and gene expression in human mesenchymal stem cells and cancer cells of various origins
Jeon, B.-G., Kumar, B. M., Kang, E., Ock, S., Lee, S., Kwack, D.-O., Byun, J., Park, B.-W., & Rho, G. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1191-9 · Cited by 51
Mesenchymal Stem Cells and the Treatment of Conditions and Diseases: The Less Glittering Side of a Conspicuous Stem Cell for Basic Research
Minguell, J. J., Allers, C., & Lasala, G. P. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0417 · Cited by 49
PDGF regulated migration of mesenchymal stem cells towards malignancy acts via the PI3K signaling pathway
Salha, S., Gehmert, S., Brébant, V., Anker, A., Loibl, M., Prantl, L., & Gehmert, S. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189319 · Cited by 48
Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells
Kučerová, L., KOVACOVICOVA, M., Polák, Š., Boháč, M., Fedeleš, J., Palenčár, D., & Matúšková, M. (2011) · Neoplasma · doi:10.4149/neo_2011_05_361 · Cited by 49
Pigment Epithelial-Derived Factor and Melanoma Differentiation Associated Gene-7 Cytokine Gene Therapies Delivered by Adipose-Derived Stromal/Mesenchymal Stem Cells are Effective in Reducing Prostate Cancer Cell Growth
Zolochevska, O., Yu, G., Gimble, J. M., & Figueiredo, M. L. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0247 · Cited by 47
Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion
Hillers‐Ziemer, L. E., D’Amato, J. V., Chamberlin, T., Paderta, G., & Arendt, L. M. (2018) · Neoplasia · doi:10.1016/j.neo.2018.09.004 · Cited by 48
Two sides of the same coin: stem cells in cancer and regenerative medicine
Ilmer, M., Vykoukal, J. V., Boiles, A. R., Coleman, M., & Alt, E. (2014) · The FASEB Journal · doi:10.1096/fj.13-244640 · Cited by 48
Self-citation
Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation
Fang, J., Chen, F., Liu, D., Gu, F., & Wang, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01955-6 · Cited by 47
Breast reconstruction de novo by water-jet assisted autologous fat grafting – a retrospective study
Hoppe, D. L., Ueberreiter, K., Surlemont, Y., Peltoniemi, H. H., Stabile, M., & Kauhanen, S. (2013) · Europe PMC (PubMed Central) · doi:10.3205/000185 · Cited by 45
The Role of Stem Cells in Aesthetic Surgery
McArdle, A., Senarath-Yapa, K., Walmsley, G. G., Hu, M. S.-M., Atashroo, D. A., Tevlin, R., Zielins, E. R., Gurtner, G. C., Wan, D. C., & Longaker, M. T. (2014) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000000404 · Cited by 45
Concise Review: Therapeutic Potential of Adipose Tissue-Derived Angiogenic Cells
Szöke, K., & Brinchmann, J. E. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0069 · Cited by 45
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis
Graham, N., & Qian, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041121 · Cited by 45
The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds
Dabiri, G., Heiner, D., & Falanga, V. (2013) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2013.833184 · Cited by 44
Adipose Tissue and Stem/Progenitor Cells
Kapur, S. K., Dos-Anjos, S., Llull, R., & Katz, A. J. (2015) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2014.12.010 · Cited by 44
Improving Autologous Fat Grafting in Regenerative Surgery through Stem Cell-Assisted Lipotransfer
Debuc, B., Gendron, N., Cras, A., Rancic, J., Philippe, A., Cetrulo, C. L., Lellouch, A. G., & Smadja, D. M. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10568-4 · Cited by 50
Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes
Nahor, I., Leshansky, L., Shivtiel, S., Eldor, L., Aberdam, D., Itskovitz‐Eldor, J., & Berrih‐Aknin, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.108860 · Cited by 43
Classification and biology of tumour associated stromal cells
Raffaghello, L., & Dazzi, F. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.016 · Cited by 47
Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications
Hogan, N. M., Dwyer, R. M., Joyce, M., & Kerin, M. J. (2012) · International Journal of Cancer · doi:10.1002/ijc.27458 · Cited by 42
Interleukin‐8 derived from local tissue‐resident stromal cells promotes tumor cell invasion
Welte, G., Alt, E., Devarajan, E., Krishnappa, S., Jotzu, C., & Song, Y. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20854 · Cited by 41
Self-citation
Mesenchymal Stem Cells and Cancer: Tumor-Specific Delivery Vehicles or Therapeutic Targets?
Dwyer, R. M., & Kerin, M. J. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.135 · Cited by 41
Adipocyte-Based Cell Therapy in Oncology: The Role of Cancer-Associated Adipocytes and Their Reinterpretation as Delivery Platforms
Munteanu, R. A., Onaciu, A., Moldovan, C. S., Zimța, A., Gulei, D., Paradiso, A., Lazar, V., & Berindan‐Neagoe, I. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050402 · Cited by 40
Mesenchymal Stem Cell Therapy and Delivery Systems in Nonhealing Wounds
Brower, J., Blumberg, S. N., Carroll, E., Pastar, I., Brem, H., & Chen, W. (2011) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000407648.89961.a6 · Cited by 38
Adipose tissue-to-breast cancer crosstalk: Comprehensive insights
Wu, Y., Li, X., Li, Q., Cheng, C., & Zheng, L. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188800 · Cited by 39
Reversible Adipose Tissue Enlargement Induced by External Tissue Suspension: Possible Contribution of Basic Fibroblast Growth Factor in the Preservation of Enlarged Tissue
D, H. K. M., D, H. S. M., D, H. E. M., Araki, J., D, N. A. M., Doi, K., Iida, T., Tabata, Y., & Yoshimura, K. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0551 · Cited by 38
Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review)
Yu, X., Ren, X., Liang, X., & Tang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9577 · Cited by 38
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer
Bunnell, B. A., Martin, E. C., Matossian, M. D., Brock, C. K., Nguyen, K., Collins‐Burow, B. M., & Burow, M. E. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10063-1 · Cited by 39
Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells
Li, N., Qin, H., Zhu, F., Ding, H., Chen, Y., Lin, Y., Deng, R., Ma, T., Lv, Y., Xiong, C., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01309-0 · Cited by 40
Bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion
Yu, F., Hu, W., He, B., Zheng, Y., Zhang, Q., & Chen, L. (2015) · World Journal of Surgical Oncology · doi:10.1186/s12957-015-0465-1 · Cited by 38
An Animal Model of Local Breast Cancer Recurrence in the Setting of Autologous Fat Grafting for Breast Reconstruction
Tsuji, W., Valentin, J. E., Marra, K. G., Donnenberg, A. D., Donnenberg, V. S., & Rubin, J. P. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0062 · Cited by 39
Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma
Ribeiro, R. J. T., Monteiro, C., Silvestre, R., Castela, Â., Coutinho, H., Fraga, A. M., Príncipe, P., Lobato, C., Costa, C., Cordeiro‐da‐Silva, A., et al. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012131 · Cited by 37
Periostin mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth in a xenograft lung adenocarcinoma model
Heo, S. C., Lee, K. O., Shin, S., Kwon, Y. W., Kim, Y. M., Lee, C. H., Kim, Y. D., Lee, M. K., Yoon, M., & Kim, J. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.08.004 · Cited by 36
Human Adipose Tissue-Derived Stromal/Stem Cells Promote Migration and Early Metastasis of Head and Neck Cancer Xenografts
Rowan, B. G., Lacayo, E. A., Sheng, M., Anbalagan, M., Gimble, J. M., Jones, R. K., Joseph, W. J., Friedlander, P. L., & Chiu, E. S. (2015) · Aesthetic Surgery Journal · doi:10.1093/asj/sjv090 · Cited by 35
Human breast cancer stem cells and sex hormones-a narrative review
Eden, J. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181d3cdd7 · Cited by 35
Adipose-Derived Stem Cells in Aesthetic Surgery
Glass, G. E., & Ferretti, P. (2018) · Aesthetic Surgery Journal · doi:10.1093/asj/sjy160 · Cited by 36
Adipose tissue-derived stem cells promote pancreatic cancer cell proliferation and invasion
Ji, S. Q., Cao, J., Zhang, Q. Y., Li, Y., Yan, Y., & Yu, F. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20132907 · Cited by 35
Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis
Wang, W., Wang, Q., Huang, D., Sun, Q.-K., Wu, S., Zhao, Y., Jia, W., Hu, D., & He, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.01.011 · Cited by 34
CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression
Zhao, R., Kaakati, R. N., Liu, X., Xu, L., Lee, A. K., Bachelder, R. E., Li, C., & Hollenbeck, S. T. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005316 · Cited by 35
Autologous stem cells for personalised medicine
Prasongchean, W., & Ferretti, P. (2012) · New Biotechnology · doi:10.1016/j.nbt.2012.04.002 · Cited by 34
Adipose Stem Cells and Cancer: Concise Review
Sabol, R. A., Giacomelli, P., Beighley, A., & Bunnell, B. A. (2019) · Stem Cells · doi:10.1002/stem.3050 · Cited by 33
Oncological safety of breast cancer patients undergoing free-flap reconstruction and lipofilling
Masià, J., Bordoni, D., Pons, G., Liuzza, C., Castagnetti, F., & Falco, G. (2015) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2015.02.008 · Cited by 32
Therapeutic effect of genetically engineered mesenchymal stem cells in rat experimental leptomeningeal glioma model
Gu, C., Li, S., Tokuyama, T., Yokota, N., & Namba, H. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.10.020 · Cited by 32
Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response
Bhat, V., Allan, A. L., & Raouf, A. (2019) · Cancers · doi:10.3390/cancers11091240 · Cited by 33
Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device
Rahman, S. M., Campbell, J. M., Coates, R., Render, K. M., Byrne, C. E., Martin, E. C., & Melvin, A. T. (2020) · Lab on a Chip · doi:10.1039/d0lc00142b · Cited by 32
The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity
Fico, F., & Santamaria‐Martínez, A. (2020) · Cancers · doi:10.3390/cancers12123863 · Cited by 32
Interaction and self-organization of human mesenchymal stem cells and neuro-blastoma SH-SY5Y cells under co-culture conditions: A novel system for modeling cancer cell micro-environment
Rizvanov, A. A., YALVAÇ, M. E., Shafigullina, A. K., Salafutdinov, I. I., Blatt, N. L., Şahi̇n, F., Kiyasov, A. P., & Palotás, A. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.05.012 · Cited by 32
Obesity-Altered Adipose Stem Cells Promote ER+ Breast Cancer Metastasis through Estrogen Independent Pathways
Sabol, R. A., Beighley, A., Giacomelli, P., Wise, R. M., Harrison, M. A. A., O’Donnnell, B. A., Sullivan, B. N., Lampenfeld, J. D., Matossian, M. D., Bratton, M. R., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061419 · Cited by 33
Tissue Engineering for Plastic Surgeons: A Primer
Golas, A. R., Hernandez, K. A., & Spector, J. A. (2013) · Aesthetic Plastic Surgery · doi:10.1007/s00266-013-0255-5 · Cited by 29
Breast Tumor Microenvironment Can Transform Naive Mesenchymal Stem Cells into Tumor-Forming Cells in Nude Mice
Wörner, P., Schächtele, D. J., Barabadi, Z., Srivastav, S., Chandrasekar, B., Izadpanah, R., & Alt, E. (2019) · Stem Cells and Development · doi:10.1089/scd.2018.0110 · Cited by 28
Self-citation
IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis
Sağlam, Ö., HALBUTOĞULLARI, Z. S., Subaşı, C., Ulukaya, E., & Karaöz, E. (2015) · Tumor Biology · doi:10.1007/s13277-015-3241-5 · Cited by 29
Do mesenchymal stromal cells influence microscopic residual or metastatic osteosarcoma in a murine model?
Aanstoos, M. E., Regan, D. P., Rose, R. J., Chubb, L. S., & Ehrhart, N. P. (2016) · Clinical Orthopaedics & Related Research · doi:10.1007/s11999-015-4362-2 · Cited by 28
JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells
Recio‐Boiles, A., Ilmer, M., Rhea, P. R., Kettlun, C. S., Heinemann, M. L., Ruetering, J., Vykoukal, J. V., & Alt, E. (2016) · Oncotarget · doi:10.18632/oncotarget.7066 · Cited by 28
Self-citation
Adipose Tissue-Derived Stem Cell Therapy for Post-Surgical Breast Reconstruction - More Light than Shadows
Bielli, A., Scioli, M. G., Gentile, P., Cervelli, V., & Orlandi, A. (2015) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/31673 · Cited by 28
Tumor-driven Molecular Changes in Human Mesenchymal Stromal Cells
Kučerová, L., Zmajkovic, J., Toro, L., Miklikova, S., Demková, L., & Matúšková, M. (2014) · Cancer Microenvironment · doi:10.1007/s12307-014-0151-9 · Cited by 28
Tumor microenvironment and the role of mesenchymal stromal cells
KUCEROVA, L., & SKOLEKOVA, S. (2012) · Neoplasma · doi:10.4149/neo_2013_001 · Cited by 27
Anti-Proliferative Activity of Glucagon-Like Peptide-1 Receptor Agonist on Obesity-Associated Breast Cancer: The Impact on Modulating Adipokines’ Expression in Adipocytes and Cancer Cells
Alanteet, A. A., Attia, H., Shaheen, S. Y., Al-Fayez, M., & Alshanawani, B. (2021) · Dose-Response · doi:10.1177/1559325821995651 · Cited by 27
Altered Adipokine Expression in Tumor Microenvironment Promotes Development of Triple Negative Breast Cancer
Papakonstantinou, Ε., Piperigkou, Z., Karamanos, N. K., & Zolota, V. (2022) · Cancers · doi:10.3390/cancers14174139 · Cited by 31
Flavonoids Restore Platinum Drug Sensitivity to Ovarian Carcinoma Cells in a Phospho-ERK1/2-Dependent Fashion
Carmi, Y. K., Mahmoud, H., Khamaisi, H., Adawi, R., Gopas, J., & Mahajna, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186533 · Cited by 26
Human mesenchymal stromal cell therapy for prevention and recovery of chemo/radiotherapy adverse reactions
Hendijani, F. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.10.015 · Cited by 25
Natriuretic Peptide Receptor A Signaling Regulates Stem Cell Recruitment and Angiogenesis: A Model to Study Linkage Between Inflammation and Tumorigenesis
Mallela, J. P., Ravi, S., Louis, F. J., Mulaney, B., Cheung, M. B., Garapati, U. S., Chinnasamy, V., Wang, C., Nagaraj, S., Mohapatra, S. S., et al. (2013) · Stem Cells · doi:10.1002/stem.1376 · Cited by 26
Tumor-associated mesenchymal stem/stromal cells in tumor microenvironment and carcinogenesis
Sun, L., Cao, X., Zhou, B., Mei, J., Zhao, X., Li, Y., Yao, Y., & Wang, M. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00688-7 · Cited by 25
Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance
Zhang, W., Torres-Rojas, C., Yue, J., & Zhu, B. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211023846 · Cited by 25
Adipose Derived Stem Cells Exert Immunomodulatory Effects on Natural Killer Cells in Breast Cancer.
Bahrami, B., Hosseini, A., Talei, A., Ghaderi, A. A., & Razmkhah, M. (2017) · PubMed Central · Cited by 25
Current Perspectives in Mesenchymal Stromal Cell Therapies for Airway Tissue Defects
Petrella, F., Rizzo, S., Borri, A., Casiraghi, M., & Spaggiari, L. (2015) · Stem Cells International · doi:10.1155/2015/746392 · Cited by 24
Comparative Study of Adipose-Derived Stem Cells From Abdomen and Breast
Guneta, V., Tan, N. S., Sugii, S., Lim, T. C., Wong, T. C. M., & Choong, C. S. N. (2016) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000000797 · Cited by 24
Association of obesity and circulating adipose stromal cells among breast cancer survivors
Ghosh, S., Hughes, D. C., Parma, D. L., Ramírez, A. G., & Li, R. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3146-1 · Cited by 24
A key driver to promote HCC: Cellular crosstalk in tumor microenvironment
Liu, P., Lingyu, K., Liu, Y., Li, G., Xie, J., & Lu, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1135122 · Cited by 26
Cancer and normal adipose‐derived mesenchymal stem cells (ASCs): Do they have differential effects on tumor and immune cells?
Razmkhah, M., Mansourabadi, Z., Mohtasebi, M. S., Talei, A., & Ghaderi, A. A. (2017) · Cell Biology International · doi:10.1002/cbin.10905 · Cited by 23
Fibroblasts Promote Proliferation and Matrix Invasion of Breast Cancer Cells in Co‐Culture Models
Plaster, M., Singh, S. K., & Tavana, H. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900121 · Cited by 27
Culture medium of bone marrow-derived human mesenchymal stem cells effects lymphatic endothelial cells and tumor lymph vessel formation
Zhan, J., Li, Y., Yu, J. Q., ZHAO, Y., Cao, W., Ma, J., Sun, X., Sun, L., Qian, H., Zhu, W., et al. (2015) · Oncology Letters · doi:10.3892/ol.2015.2868 · Cited by 22
Development of growth factor-immobilizable material for hepatocyte transplantation
Hou, Y., Ijima, H., Shirakigawa, N., Takei, T., & Kawakami, K. (2012) · Biochemical Engineering Journal · doi:10.1016/j.bej.2012.09.007 · Cited by 22
Synthetic Adipose Tissue Models for Studying Mammary Gland Development and Breast Tissue Engineering
Wang, X., Reagan, M. R., & Kaplan, D. L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9192-y · Cited by 22
Human Adipose Derived Stem Cells Induced Cell Apoptosis and S Phase Arrest in Bladder Tumor
Yu, X., Su, B., Ge, P., Wang, Z., Li, S., Huang, B., Gong, Y., & Lin, J. (2015) · Stem Cells International · doi:10.1155/2015/619290 · Cited by 21
Wound Microenvironment Sequesters Adipose-Derived Stem Cells in a Murine Model of Reconstructive Surgery in the Setting of Concurrent Distant Malignancy
Altman, A. M., Prantl, L., Muehlberg, F. L., Song, Y., Seidensticker, M., Butler, C. E., & Alt, E. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31820a6400 · Cited by 21
Self-citation
Promotion of Primary Murine Breast Cancer Growth and Metastasis by Adipose-Derived Stem Cells Is Reduced in the Presence of Autologous Fat Graft
Gebremeskel, S., Gencarelli, J. R., Gareau, A. J., LeVatte, T. L., Dugandzic, B. S. A., Johnston, B., & Bezuhly, M. (2018) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005142 · Cited by 22
Endogenous Gastric-Resident Mesenchymal Stem Cells Contribute to Formation of Cancer Stroma and Progression of Gastric Cancer
Kim, E., Kim, H., Yang, Y., Kim, J., Choi, M.-Y., Choi, C. S., Kim, K.-H., Lee, J.-H., Jang, W.-H., & Cheong, S.-H. (2013) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2013.47.6.507 · Cited by 21
Adipose-Derived Stem Cells Facilitate Ovarian Tumor Growth and Metastasis by Promoting Epithelial to Mesenchymal Transition Through Activating the TGF-β Pathway
Liu, X., Zhao, G., Huo, X., Wang, Y., Tigyi, G., Zhu, B., Yue, J., & Zhang, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756011 · Cited by 20
An osteosarcoma-on-a-chip model for studying osteosarcoma matrix-cell interactions and drug responses
Lu, Z., Miao, X., Zhang, C., Sun, B., Skardal, A., Atala, A., Ai, S., Gong, J., Hao, Y., Zhao, J., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.005 · Cited by 23
Development of a novel bioabsorbable implant that is substituted by adipose tissue in vivo
Ogino, S., Morimoto, N., Sakamoto, M., Jinno, C., Yoshikawa, K., Enoshiri, T., Sakamoto, Y., Taira, T., & Suzuki, S. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2482 · Cited by 19
Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches
Jazedje, T., Ribeiro, A. L., Pelatti, M., Bueno, H. M. D. S., Nagata, G. Y., Trierveiler, M., Rodrigues, E. G., & Zatz, M. (2015) · Stem Cells International · doi:10.1155/2015/796215 · Cited by 18
Associations of miR-146a and miR-146b expression and breast cancer in very young women
Li, Y., Xu, Y., Yu, C., & Zuo, W. (2015) · Cancer Biomarkers · doi:10.3233/cbm-150532 · Cited by 18
Fat grafting for breast cancer patients: From basic science to clinical studies
Gennari, R., Griguolo, G., Dieci, M. V., Guarneri, V., Tavaniello, B., Sibilio, A., & Conte, P. (2016) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2016.04.062 · Cited by 18
Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell-cell interaction.
Pietilä, M., Lehenkari, P., Kuvaja, P., Kaakinen, M., Kaul, S., Wadhwa, R., & Uemura, T. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.023 · Cited by 19
Homeostatic Imbalance and Colon Cancer: The Dynamic Epigenetic Interplay of Inflammation, Environmental Toxins, and Chemopreventive Plant Compounds
Sokolosky, M. L., & Wargovich, M. J. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00057 · Cited by 17
In Vitro Effects of Adipose-Derived Stem Cells on Breast Cancer Cells Harvested From the Same Patient
Charvet, H. J., Orbay, H., Harrison, L., Devi, K., & Sahar, D. E. (2016) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000000802 · Cited by 18
Imaging changes after breast reconstruction with fat grafting - Retrospective study of 90 Breast Cancer
Noor, L., Reeves, H. R., Kumar, D., Alozairi, O., & Bhaskar, P. (2016) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.321.9460 · Cited by 17
Adipose Stem Cell Therapy in Cancer Reconstruction
Alperovich, M. A., Lee, Z., Friedlander, P. L., Rowan, B. G., Gimble, J. M., & Chiu, E. S. (2014) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000000283 · Cited by 17
Chemokines and Chemokine Receptors Expression in the Adipose Derived Stem Cells (ASCs), Breast Tissues and in Peripheral Blood of Patients with Breast Cancer
Razmkhah, M., & Jaberipour, M. (2011) · Journal of Carcinogenesis & Mutagenesis · doi:10.4172/2157-2518.1000120 · Cited by 17
3D-cultured adipose tissue-derived stem cells inhibit liver cancer cell migration and invasion through suppressing epithelial-mesenchymal transition
Xie, H., Liao, N., Lan, F., Cai, Z., Liu, X., & Liu, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3336 · Cited by 19
Human Adipose-Derived Stromal/Stem Cells Induce Functional CD4 + CD25 + FoxP3 + CD127 − Regulatory T Cells Under Low Oxygen Culture Conditions
Frazier, T. P., McLachlan, J. B., Gimble, J. M., Tucker, H. A., & Rowan, B. G. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0152 · Cited by 16
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth
Do, E. K., Kim, Y. M., Heo, S. C., Kwon, Y. W., Shin, S. H., Suh, D., Kim, K., Yoon, M., & Kim, J. H. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.004 · Cited by 15
Interplay between mesenchymal stem cell and tumor and potential application
Wang, Q., Li, T., Wu, W., & Ding, G. (2020) · Human Cell · doi:10.1007/s13577-020-00369-z · Cited by 14
Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study
Yuan, Z., Zhu, Z., Zhu, F., Ding, F., Wang, Y., Wang, X., Luo, X., Yang, J., Liu, F., & Sun, D. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02512-5 · Cited by 15
Breast cancer, stem cells and sex hormones. Part 3: The impact of the menopause and hormone replacement
Eden, J. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.11.005 · Cited by 14
Host-Derived Pericytes and Sca-1 + Cells Predominate in the MART-1 − Stroma Fraction of Experimentally Induced Melanoma
Trevino-Villarreal, J. H., Cotanche, D. A., Sepúlveda, R., Bortoni, M. E., Manneberg, O., Udagawa, T., & Rogers, R. A. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411428078 · Cited by 14
Adipocyte-Derived Stem and Regenerative Cells in Facial Rejuvenation
Cohen, S. R., & Mailey, B. A. (2012) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2012.07.014 · Cited by 14
Effects of human adipose-derived stem cells on the regeneration of damaged visceral pleural mesothelial cells: a morphological study in a rabbit model
Kim, Y.-D., Jun, Y. J., Kim, J., & Kim, C. K. (2014) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivu124 · Cited by 14
Effect of truncated neurokinin‐1 receptor expression changes on the interaction between human breast cancer and bone marrow‐derived mesenchymal stem cells
Zhou, Y., Zuo, D., Wang, M., Zhang, Y., Yu, M., Yang, J., & Yao, Z. (2014) · Genes to Cells · doi:10.1111/gtc.12168 · Cited by 14
Autologous fat grafting after sarcoma surgery: Evaluation of oncological safety
Pennati, A., Riggio, E., Marano, G., & Biganzoli, E. M. (2018) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2018.07.028 · Cited by 14
Minimally invasive esthetic procedures of the male breast
Wollina, U., & Goldman, A. (2011) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00548.x · Cited by 14
Mesenchymal Stromal Cells from Female Donors Enhance Breast Cancer Cell Proliferation in vitro
Pasanen, I., Pietilä, M., Lehtonen, S. T., Lehtilahti, E., Hakkarainen, T., Sequeiros, R. T. B., Lehenkari, P. P., & Kuvaja, P. (2014) · Oncology · doi:10.1159/000368556 · Cited by 14

Authors: Muehlberg, F. L., Song, Y.-H., Krohn, A., Pinilla, S. P., Droll, L. H., Leng, X., Seidensticker, M., Ricke, J., Altman, A. M., Devarajan, E., Liu, W., Arlinghaus, R. B., & Alt, E. U.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
University Hospital Magdeburg (DE)
Corresponding author: Alt, Eckhard U.
ORCID: Muehlberg, Fabian L.
Krohn, Alexander
Leng, Xiaohong
Seidensticker, Max
Ricke, Jens
Liu, Weili
Alt, Eckhard U.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2009-01-30
Volume: 30
Issue: 4
Pages: 589-597
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/bgp036
OpenAlex: W2107402669
Cited by: 330
References: 71
Citations by year: 2026: 2 · 2025: 5 · 2024: 13 · 2023: 9 · 2022: 11 · 2021: 19 · 2020: 10 · 2019: 17 · 2018: 18 · 2017: 13 · 2016: 20 · 2015: 33 · 2014: 35 · 2013: 24 · 2012: 31
FWCI: 16.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
BORIS (University Library Bern) (submittedVersion, other-oa)
Open Access CRIS of the University of Bern
Funders: U.S. Department of Defense (W81XWH, W81XWH0810523)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: tissue-resident stem cells, adipose-derived stem cells, breast cancer, tumor growth, metastasis, CXCL12, CXCR4, paracrine signaling, tumor cell motility, tumor invasion, stem cell homing, tumor vasculature, endothelial differentiation, tumor microenvironment, 4T1 cells, MDA-MB-231 cells
MeSH terms: Adipose Tissue, Animals, Cell Movement, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Lung Neoplasms, Male, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Neovascularization, Pathologic, Neoplastic Stem Cells, Blotting, Western, Mammary Neoplasms, Animal, Stromal Cells, Spheroids, Cellular, Receptors, CXCR4, Vascular Endothelial Growth Factor A, Immunoprecipitation, Mice, Chemokine CXCL12

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tissue-resident stem cells promote breast cancer growth and metastasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks