CoChat
Sign Up
Cited by 149Meat and Animal Product QualityCarcinogens and Genotoxicity AssessmentNutritional Studies and Diet

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effect of processed and red meat on endogenous nitrosation and DNA damage

Open access
Joosen, A. M.C.P., Kuhnle, G. G.C., Aspinall, S. M., Barrow, T. M., Lecommandeur, E., Azqueta, A., Collins, A. R., Bingham, S. A.·2009·Carcinogenesis
DOI 10.1093/carcin/bgp130PMC PMC2718076
Open this paper in CoChat — free accountOpen PDF

Abstract

Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and six females) and of a nitrite-preserved red meat (PM) versus a VEG diet (5 males and 11 females), we investigated whether processing of meat might increase colorectal cancer risk by stimulating nitrosation and DNA damage. Meat diets contained 420 g (males) or 366 g (females) meat/per day. Faecal homogenates from day 10 onwards were analysed for haem and NOC and associated supernatants for genotoxicity. Means are adjusted for differences in male to female ratios between studies. Faecal NOC concentrations on VEG diets were low (2.6 and 3.5 mmol/g) but significantly higher on meat diets (PM 175 +/- 19 nmol/g versus RM 185 +/- 22 nmol/g; P = 0.75). The RM diet resulted in a larger proportion of nitrosyl iron (RM 78% versus PM 54%; P < 0.0001) and less nitrosothiols (RM 12% versus PM 19%; P < 0.01) and other NOC (RM 10% versus PM 27%; P < 0.0001). There was no statistically significant difference in DNA breaks induced by faecal water (FW) following PM and RM diets (P = 0.80). However, PM resulted in higher levels of oxidized pyrimidines (P < 0.05). Surprisingly, VEG diets resulted in significantly more FW-induced DNA strand breaks than the meat diets (P < 0.05), which needs to be clarified in further studies. Meats cured with nitrite have the same effect as fresh RM on endogenous nitrosation but show increased FW-induced oxidative DNA damage.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/carcin/bgp130

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 37 references

Research works printed but not linked: 2

  1. 1985, 89, 19
  2. Cross, 2003, Cancer Research, 63, 2358

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Joosen, A. M. C. P., Kuhnle, G. G. C., Aspinall, S. M., Barrow, T. M., Lecommandeur, E., Azqueta, A., Collins, A. R., & Bingham, S. A.
Affiliations
  • MRC Mitochondrial Biology Unit (GB)
  • University of Oslo (NO)
Corresponding author
Joosen, A. M.C.P.
ORCID
Venue
Carcinogenesis
Publisher
Oxford University Press (OUP)
Published
2009-06-04
Volume
30
Issue
8
Pages
1402-1407
ISSN
  • 0143-3334 (ISSN-L)
  • 1460-2180
DOI
10.1093/carcin/bgp130
PMC
PMC2718076
OpenAlex
W2119694706
Cited by
149
References
37
Citations by year
2026: 5 · 2025: 2 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 7 · 2013: 10 · 2012: 7
FWCI
14.10
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Carcinogenesis (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Sunderland Repository (University of Sunderland) (acceptedVersion)
  • CentAUR (University of Reading) (submittedVersion, other-oa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
processed meat, red meat, nitrosation, nitroso compounds, DNA damage, heme, nitrite, colorectal cancer risk, S-nitrosothiols, vegetarian diet
MeSH terms
Adult, Aged, Aged, 80 and over, DNA Damage, Feces, Female, Heme, Humans, Male, Meat, Middle Aged, Mutagens, Nitroso Compounds, Diet, Vegetarian, Nitrosation, Cross-Over Studies, Comet Assay, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review