The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Effect of processed and red meat on endogenous nitrosation and DNA damage
Open accessAbstract
Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and six females) and of a nitrite-preserved red meat (PM) versus a VEG diet (5 males and 11 females), we investigated whether processing of meat might increase colorectal cancer risk by stimulating nitrosation and DNA damage. Meat diets contained 420 g (males) or 366 g (females) meat/per day. Faecal homogenates from day 10 onwards were analysed for haem and NOC and associated supernatants for genotoxicity. Means are adjusted for differences in male to female ratios between studies. Faecal NOC concentrations on VEG diets were low (2.6 and 3.5 mmol/g) but significantly higher on meat diets (PM 175 +/- 19 nmol/g versus RM 185 +/- 22 nmol/g; P = 0.75). The RM diet resulted in a larger proportion of nitrosyl iron (RM 78% versus PM 54%; P < 0.0001) and less nitrosothiols (RM 12% versus PM 19%; P < 0.01) and other NOC (RM 10% versus PM 27%; P < 0.0001). There was no statistically significant difference in DNA breaks induced by faecal water (FW) following PM and RM diets (P = 0.80). However, PM resulted in higher levels of oxidized pyrimidines (P < 0.05). Surprisingly, VEG diets resulted in significantly more FW-induced DNA strand breaks than the meat diets (P < 0.05), which needs to be clarified in further studies. Meats cured with nitrite have the same effect as fresh RM on endogenous nitrosation but show increased FW-induced oxidative DNA damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A high red meat intake (rich in heme iron), increases endogenous formation of N-nitroso compounds in the gastrointestinal tract that are associated with increased epithelial proliferation, oxidative stress, and iron-induced hypoxia signaling (166–168).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [168]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Comet Assay for DNA Damage and Repair: Principles, Applications, and Limitations
Collins, A. R. (2004) · Molecular Biotechnology · doi:10.1385/mb:26:3:249 · Cited by 2,892
Self-citationNorat, T., Bingham, S. A., Ferrari, P., Slimani, N., Jenab, M., Mazuir, M., Overvad, K., Olsen, A., Tjønneland, A. M., Clavel‐Chapelon, F., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji164 · Cited by 875
Meat consumption and risk of colorectal cancer: A meta‐analysis of prospective studies
Larsson, S. C., & Wolk, A. (2006) · International Journal of Cancer · doi:10.1002/ijc.22170 · Cited by 663
A Prospective Study of Red and Processed Meat Intake in Relation to Cancer Risk
Cross, A. J., Leitzmann, M. F., Gail, M. H., Hollenbeck, A. R., Schatzkin, A. G., & Sinha, R. R. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040325 · Cited by 476
Feelisch, M., Rassaf, T., Mnaimneh, S., Singh, N., Bryan, N. S., Jourd'Heuil, D., & Kelm, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0363com · Cited by 401
(2003) · PubMed · Cited by 381
Overview of carcinogenic heterocyclic amines
Sügimura, T. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00045-6 · Cited by 331
Measurement of the mean transit time of dietary residue through the human gut.
Cummings, J. H., Jenkins, D. J. A., & Wiggins, H. S. (1976) · Gut · doi:10.1136/gut.17.3.210 · Cited by 284
Bingham, S. A., Hughes, R., & Cross, A. J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.11.3522s · Cited by 279
Research works printed but not linked: 2
- 1985, 89, 19
- Cross, 2003, Cancer Research, 63, 2358
Cited by
Sorted by citations
Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies
Chan, D. S. M., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020456 · Cited by 903
American Cancer Society guideline for diet and physical activity for cancer prevention
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21591 · Cited by 789
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507
Rohrmann, S., Overvad, K., Bueno-de-Mesquita, H. B., Jakobsen, M. U., Egeberg, R., Tjønneland, A., Nailler, L., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Krogh, V., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-63 · Cited by 454
Bastide, N. M., Pierre, F. H. F., & Corpet, D. E. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0113 · Cited by 397
Metadata
- Authors
- Joosen, A. M. C. P., Kuhnle, G. G. C., Aspinall, S. M., Barrow, T. M., Lecommandeur, E., Azqueta, A., Collins, A. R., & Bingham, S. A.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- University of Oslo (NO)
- Corresponding author
- Joosen, A. M.C.P.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-04
- Volume
- 30
- Issue
- 8
- Pages
- 1402-1407
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- PMC
- PMC2718076
- OpenAlex
- W2119694706
- Cited by
- 149
- References
- 37
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 7 · 2013: 10 · 2012: 7
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Carcinogenesis (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Sunderland Repository (University of Sunderland) (acceptedVersion)
- CentAUR (University of Reading) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- processed meat, red meat, nitrosation, nitroso compounds, DNA damage, heme, nitrite, colorectal cancer risk, S-nitrosothiols, vegetarian diet
- MeSH terms
- Adult, Aged, Aged, 80 and over, DNA Damage, Feces, Female, Heme, Humans, Male, Meat, Middle Aged, Mutagens, Nitroso Compounds, Diet, Vegetarian, Nitrosation, Cross-Over Studies, Comet Assay, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
