The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The EMT regulator slug and lung carcinogenesis
Abstract
Lung cancer is the leading cause of cancer death worldwide. Cancer metastasis and resistance to treatment (including radiotherapy, chemotherapy and targeted therapy) are two major causes for the poor survival of lung cancer patients. Epithelial-mesenchymal transition (EMT) is involved in cancer cell invasion, resistance to apoptosis and stem cell features. The process of EMT is controlled by a group of transcriptional factors, zinc finger proteins and basic helix-loop-helix factors. Signaling pathways activated by intrinsic or extrinsic stimuli converge on these transcriptional factors and regulated the phenotypic changes of cancer cells. These EMT regulators may play an important role in cancer progression. In lung cancer, Slug is the most thoroughly investigated EMT regulator. The expression of Slug is associated with lung cancer invasion and resistance to target therapy. In this review, we focus on the current understanding of the role of Slug in the carcinogenesis and progression of lung cancer.
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International Journal of Oncology
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Cited by
Non-redundant functions of EMT transcription factors
Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0196-y · Cited by 524
LIU, R.-Y., ZENG, Y., LEI, Z., WANG, L., YANG, H., LIU, Z., ZHAO, J., & ZHANG, H.-T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2310 · Cited by 308
Liu, X., Sun, H., Qi, J., Wang, L., He, S., Liu, J., Feng, C., Chen, C., Li, W., Guo, Y., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2765 · Cited by 208
Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer
Nurwidya, F., Takahashi, F., Murakami, A., & Takahashi, K. (2012) · Cancer Research and Treatment · doi:10.4143/crt.2012.44.3.151 · Cited by 177
Li, N., Li, Y., Lv, J., Zheng, X., Wen, H., Shen, H., Zhu, G., Chen, T.-Y., Dhar, S. S., Kan, P.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.035 · Cited by 141
Metadata
- Authors
- Shih, J.-Y., & Yang, P.-C.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-10
- Volume
- 32
- Issue
- 9
- Pages
- 1299-1304
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2096966618
- Cited by
- 317
- References
- 60
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shih, J.-Y., & Yang, P.-C. (2011). The EMT regulator slug and lung carcinogenesis. Carcinogenesis. https://doi.org/10.1093/carcin/bgr110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
