The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Postnatal Development of Radial Glia and the Ventricular Zone (VZ): a Continuum of the Neural Stem Cell Compartment
Abstract
The germinal neuroepithelium, or ventricular zone (VZ) of the developing fetal brain, was once thought to transform into the non-germinal ependymal zone of the postnatal and adult brain. Persistence of neural stem cells and neurogenesis throughout postnatal life, however, suggests a continuum between embryonic and adult germinal brain centers. Here, we suggest that developmental changes in anatomy and molecular marker expression in the ventricular walls (the principal germinal centers of the brain) may have misled us into current interpretations of VZ transformation from a germinal to a non-germinal epithelium. We review previous studies and present new data indicating that a germinal layer with characteristics similar to those of the embryonic VZ persists in lateral ventricular walls of the postnatal mouse brain, a region where the adult subventricular zone (SVZ) develops and where neurogenesis persists into adult life. The early postnatal VZ is largely composed of radial glial cell bodies that remain proliferative, display interkinetic nuclear migration and serve as progenitors of new neurons. Ependymal cells then progressively populate the walls of the lateral ventricle but a subpopulation of astrocytes, derived from radial glia, remain in contact with the ventricle lumen, into which they extend a single cilium similar to that found on neuroepithelial cells and radial cells. We propose that a VZ 'compartment' is retained postnatally and that this niche may be essential for stem cell function.
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Long-Distance Neuronal Migration in the Adult Mammalian Brain
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Neurons derived from radial glial cells establish radial units in neocortex
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Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
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Vascular niche for adult hippocampal neurogenesis
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Astrocytes give rise to new neurons in the adult mammalian hippocampus
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Cited by
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Radial glia give rise to adult neural stem cells in the subventricular zone
Merkle, F. T., Tramontin, A. D., García-Verdugo, J. M., & Alvarez-Buylla, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407893101 · Cited by 849
Self-citationImayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
Spassky, N., Merkle, F. T., Flames, N., Tramontin, A. D., García-Verdugo, J. M., & Alvarez-Buylla, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1108-04.2005 · Cited by 717
Self-citationNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
Metadata
- Authors
- Tramontin, A. D.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06-01
- Volume
- 13
- Issue
- 6
- Pages
- 580-587
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2147905750
- Cited by
- 386
- References
- 51
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- closed
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