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Cited by 49Functional Brain Connectivity StudiesNeural dynamics and brain functionNeural and Behavioral Psychology Studies

Spatiotemporal integrity and spontaneous nonlinear dynamic properties of the salience network revealed by human intracranial electrophysiology: A multicohort replication

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Das, Anup, Menon, Vinod·2020·Cerebral Cortex
DOI 10.1093/cercor/bhaa111PMC PMC7566690
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Abstract

The salience network (SN) plays a critical role in cognitive control and adaptive human behaviors, but its electrophysiological foundations and millisecond timescale dynamic temporal properties are poorly understood. Here, we use invasive intracranial EEG (iEEG) from multiple cohorts to investigate the neurophysiological underpinnings of the SN and identify dynamic temporal properties that distinguish it from the default mode network (DMN) and dorsolateral frontal–parietal network (FPN), two other large-scale brain networks that play important roles in human cognition. iEEG analysis of network interactions revealed that the anterior insula and anterior cingulate cortex, which together anchor the SN, had stronger intranetwork interactions with each other than cross-network interactions with the DMN and FPN. Analysis of directionality of information flow between the SN, DMN, and FPN revealed causal outflow hubs in the SN consistent with its role in fast temporal switching of network interactions. Analysis of regional iEEG temporal fluctuations revealed faster temporal dynamics and higher entropy of neural activity within the SN, compared to the DMN and FPN. Critically, these results were replicated across multiple cohorts. Our findings provide new insights into the neurophysiological basis of the SN, and more broadly, foundational mechanisms underlying the large-scale functional organization of the human brain.

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  • Suppression of the DMN and engagement of cognitive control networks during task performance are controlled by a common mechanism, with the salience network playing a crucial role.

    “Notably, suppression of the DMN and engagement of cognitive control networks during task performance are thought to be controlled by a common mechanism, with the salience network playing a crucial role.”

    From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [32]

    The Introduction says the DMN is typically deactivated during demanding tasks and describes the salience network’s role in cognitive control. The Discussion reports salience-network hubs involved in switching interactions with the DMN and frontal–parietal network. But the paper’s resting-state findings do not establish that one mechanism controls both DMN suppression and cognitive-control-network engagement during task performance. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Analysis of directionality of information flow between the DMN and the salience and frontoparietal networks revealed causal outflow hubs in the salience network, consistent with its role in fast temporal switching of network interactions.

    “Additionally, analysis of the directionality of information flow between the DMN and the salience and frontoparietal networks revealed causal outflow hubs in the salience network, consistent with its role in fast temporal switching of network interactions. 32”

    From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [32]

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Cited by

Sorted by citations

Authors
Das, A., & Menon, V.
Affiliations
Stanford Medicine (US)
Corresponding author
  • Das, Anup
  • Menon, Vinod
ORCID
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2020-05-19
Volume
30
Issue
10
Pages
5309-5321
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bhaa111
PMC
PMC7566690
OpenAlex
W3026888467
Cited by
49
References
7
Citations by year
2026: 7 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 6
FWCI
3.36
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (EB022907, NS086085)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
salience network, intracranial EEG, large-scale brain networks, default mode network, anterior insula, anterior cingulate cortex, network interaction, temporal dynamics, cognitive control
MeSH terms
Default Mode Network, Brain, Cognition, Electroencephalography, Humans, Neural Pathways, Signal Processing, Computer-Assisted, Reproducibility of Results, Cohort Studies, Nonlinear Dynamics

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