The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Post-pubertal Emergence of Prefrontal Cortical Up States Induced by D1-NMDA Co-activation
Abstract
Dopamine-glutamate interactions may contribute to persistent electrical activity in the prefrontal cortex (PFC). We tested whether a D1 modulation of NMDA function can result in persistent depolarization in vitro. D1-NMDA co-activation yielded depolarizing plateaus resembling in vivo up states in PFC pyramidal neurons recorded in slices from adult (PD 45-65), but not pre-pubertal (PD 29-38) rats. These plateaus required intracellular Ca2+, activation of L-type Ca2+ channels and protein kinase A. These events were eliminated by intracellular administration of the voltage-gated Na+ channel blocker QX-314 or by interrupting synaptic activity with bath application of tetrodotoxin or the AMPA antagonist CNQX, suggesting that they require both intrinsic and synaptic mechanisms. These recurrent depolarizations could constitute important elements in cortical information processing, allowing synaptic plasticity and memory functions. Acquiring these PFC D1-NMDA interactions after puberty may be a critical element for developing mature cognitive abilities.
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“There is, furthermore, ample evidence now that during embryonic development there is convergence of the various neurotransmitter signaling pathways and influence each other’s development and functioning [153, 227–231].”
From Development of prefrontal cortex (2022) · cites this paper as [228]
In the citing paper
“The same holds true for noradrenergic and dopaminergic projections towards forebrain regions as well as dopaminergic-glutamatergic and dopaminergic-cholinergic interactions controlling PFC maturation and functioning [227, 228, 231].”
From Development of prefrontal cortex (2022) · cites this paper as [228]
In the citing paper
“The D 1 -NMDA interaction in the rodent PFC becomes more robust during adolescence, allowing the emergence of persistent depolarizations in adult brain slices when D 1 and NMDA receptors are coactivated.11”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [11]
Citations
Cites
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
Neuronal Avalanches in Neocortical Circuits
Beggs, J. M., & Plenz, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11167.2003 · Cited by 2,325
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives, M. V., & McCormick, D. A. (2000) · Nature Neuroscience · doi:10.1038/79848 · Cited by 1,539
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Stuart, G. J., & Sakmann, B. (1994) · Nature · doi:10.1038/367069a0 · Cited by 1,289
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons
Wilson, C. J., & Kawaguchi, Y. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02397.1996 · Cited by 798
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
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The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Adolescence as a neurobiological critical period for the development of higher-order cognition
Larsen, B., & Luna, B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.005 · Cited by 853
Nicotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 623
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
“The same holds true for noradrenergic and dopaminergic projections towards forebrain regions as well as dopaminergic-glutamatergic and dopaminergic-cholinergic interactions controlling PFC maturation and functioning [227, 228, 231].”
Background
Metadata
- Authors
- Tseng, K. Y.
- Affiliations
- Albany Medical College (US)
- Corresponding author
- Tseng, K. Y.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-06
- Volume
- 15
- Issue
- 1
- Pages
- 49-57
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2086932421
- Cited by
- 169
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 3 · 2014: 7 · 2013: 16 · 2012: 7
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH57683)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prefrontal cortex, up states, dopamine D1 receptor, NMDA receptor, dopamine-glutamate interaction, L-type calcium channels, protein kinase A, QX-314, tetrodotoxin, CNQX, synaptic plasticity, puberty, pyramidal neurons, cognitive development
- MeSH terms
- Action Potentials, Animals, Neural Pathways, Organ Culture Techniques, Sexual Maturation, Sodium Channels, Ion Channel Gating, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Prefrontal Cortex, Receptors, Dopamine D1, Cyclic AMP-Dependent Protein Kinases, Pyramidal Cells, Patch-Clamp Techniques, Dopamine Agonists, Excitatory Amino Acid Agonists, Calcium Channels, L-Type, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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