The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Structural Brain Changes in Tinnitus
Abstract
Tinnitus is a common but poorly understood disorder characterized by ringing or buzzing in the ear. Central mechanisms must play a crucial role in generating this auditory phantom sensation as it persists in most cases after severing the auditory nerve. One hypothesis states that tinnitus is caused by a reorganization of tonotopic maps in the auditory cortex, which leads to an overrepresentation of tinnitus frequencies. Moreover, the participation of the limbic system in generating tinnitus has been postulated. Here we aimed at identifying brain areas that display structural change in tinnitus. We compared tinnitus sufferers with healthy controls by using high-resolution magnetic resonance imaging and voxel-based morphometry. Within the auditory pathways, we found gray-matter increases only at the thalamic level. Outside the auditory system, gray-matter decrease was found in the subcallosal region including the nucleus accumbens. Our results suggest that reciprocal involvement of both sensory and emotional areas are essential in the generation of tinnitus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
Maldjian, J. A., Laurienti, P. J., Kraft, R. A., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,085
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Changes in grey matter induced by training
Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004) · Nature · doi:10.1038/427311a · Cited by 2,373
Self-citationDissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Flor, H., Elbert, T., Knecht, S., Wienbruch, C., Pantev, C., Birbaumers, N., Larbig, W., & Taub, E. (1995) · Nature · doi:10.1038/375482a0 · Cited by 1,845
Brain Structures Differ between Musicians and Non-Musicians
Gaser, C., & Schlaug, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09240.2003 · Cited by 1,633
Self-citationPhantom auditory perception (tinnitus): mechanisms of generation and perception
Jastreboff, P. J. (1990) · Neuroscience Research · doi:10.1016/0168-0102(90)90031-9 · Cited by 1,576
Detecting activations in PET and fMRI: levels of inference and power
Friston, K. J., Holmes, A., Poline, J.-B., Price, C. J., & Frith, C. D. (1996) · NeuroImage · doi:10.1006/nimg.1996.0074 · Cited by 1,148
Cited by
Tuning Out the Noise: Limbic-Auditory Interactions in Tinnitus
Rauschecker, J. P., Leaver, A. M., & Mühlau, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.032 · Cited by 773
Self-citationMaladaptive plasticity in tinnitus — triggers, mechanisms and treatment
Shore, S. E., Roberts, L. E., & Langguth, B. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.12 · Cited by 474
Central gain control in tinnitus and hyperacusis
Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00206 · Cited by 439
De Ridder, D., Vanneste, S., Weisz, N., Londero, A., Schlee, W., Elgoyhen, A. B., & Langguth, B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.021 · Cited by 398
Langguth, B., Landgrebe, M., Kleinjung, T., Sand, G. P., & Hajak, G. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.575178 · Cited by 321
Metadata
- Authors
- Mühlau, M., Rauschecker, J. P., Oestreicher, E., Gaser, C., Röttinger, M., Wohlschläger, A. M., Simon, F., Etgen, T., Conrad, B., & Sander, D.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-09
- Volume
- 16
- Issue
- 9
- Pages
- 1283-1288
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2129212500
- Cited by
- 384
- References
- 47
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structural Brain Changes in Tinnitus. https://app.cochat.ai/papers/10.1093/cercor/bhj070
- The paper
- Mühlau, M., Rauschecker, J. P., Oestreicher, E., Gaser, C., Röttinger, M., Wohlschläger, A. M., Simon, F., Etgen, T., Conrad, B., & Sander, D. (2006). Structural Brain Changes in Tinnitus. Cerebral Cortex. https://doi.org/10.1093/cercor/bhj070
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
