The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid
Open accessAbstract
Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryonic exposure to VPA on microcircuit properties of juvenile rat neocortex using in vitro electrophysiology. We found that a single prenatal injection of VPA on embryonic day 11.5 causes a significant enhancement of the local recurrent connectivity formed by neocortical pyramidal neurons. The study of the biophysical properties of these connections revealed weaker excitatory synaptic responses. A marked decrease of the intrinsic excitability of pyramidal neurons was also observed. Furthermore, we demonstrate a diminished number of putative synaptic contacts in connection between layer 5 pyramidal neurons. Local hyperconnectivity may render cortical modules more sensitive to stimulation and once activated, more autonomous, isolated, and more difficult to command. This could underlie some of the core symptoms observed in humans prenatally exposed to valproic acid.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the case of apical dendrites, complexity, but not length, is increased on layer II pyramidal neurons in the motor cortex [331], decreased in the medial PFC [297], or is unchanged in layer V pyramidal neurons of the somatosensory cortex following VPA exposure in rodents [301].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [301]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,607
Self-citationJust, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589
Castelli, F. (2002) · Brain · doi:10.1093/brain/awf189 · Cited by 1,377
Autism and Abnormal Development of Brain Connectivity: Figure 1.
Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217
Differential signaling via the same axon of neocortical pyramidal neurons
Markram, H., Wang, Y., & Tsodyks, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5323 · Cited by 1,102
Self-citationMarkram, H., Lübke, J., Frotscher, M., Roth, A., & Sakmann, B. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022031 · Cited by 960
Self-citationBehavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
Schneider, T., & Przewłocki, R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300518 · Cited by 959
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–184 of 184
Desarkar, P., Rajji, T. K., Ameis, S. H., Blumberger, D. M., Lai, M., Lunsky, Y., & Daskalakis, Z. J. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.03.046 · Cited by 32
Febo, M., & Ferris, C. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.019 · Cited by 30
Altered hippocampal-dependent memory and motor function in neuropilin 2–deficient mice
Shiflett, M. W., Gavin, M., & Tran, T. S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.17 · Cited by 29
Zhang, Y., Cailing, Y., YUAN, G.-Y., WANG, Z., Cui, W., & Li, R. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1996 · Cited by 31
D'Angelo, E. U., Soda, T., Mapelli, L., Locatelli, F., Botta, L., Goldfarb, M. P., & Prestori, F. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1985-18.2019 · Cited by 33
Therapeutic strategies for treating epilepsy during pregnancy
Whelehan, A., & Delanty, N. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1550073 · Cited by 28
Gottfried, C., Bambini-Júnior, V., Baronio, D., Zanatta, G., Bristot, R., Vaccaro, T. D. S., & Riesgo, R. D. S. (2013) · InTech eBooks · doi:10.5772/54824 · Cited by 33
Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro
Delattre, V., Mendola, D. L., Meystre, J., Markram, H., & Markram, H. (2013) · Scientific Reports · doi:10.1038/srep02897 · Cited by 27
Self-citationA microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells
Yu, Y., de Campos, R. P. S., Hong, S., Krastev, D. L., Sadanand, S., Leung, Y., & Wheeler, A. R. (2019) · Microsystems & Nanoengineering · doi:10.1038/s41378-019-0049-2 · Cited by 28
Saitow, F., Takumi, T., & Suzuki, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107931 · Cited by 28
Shahrbabaki, S. S. V., Jonaidi, H., Sheibani, V., & Bashiri, H. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113739 · Cited by 27
Environmental Factors in the Onset of Autism Spectrum Disorder
Persico, A. M., & Merelli, S. (2014) · Current Developmental Disorders Reports · doi:10.1007/s40474-013-0002-2 · Cited by 26
Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting
McKinnell, Z. E., Maze, T., Ramos, A., Challans, B., & Plakke, B. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112966 · Cited by 27
Neuroconnectivity and valproic acid: The myelin hypothesis
Rosenzweig, I., Vukadinovic, Z., Turner, A. J., & Catani, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.006 · Cited by 24
Potential teratogenic effects of ultrasound on corticogenesis: Implications for autism
Williams, E. L., & Casanova, M. F. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.01.027 · Cited by 25
Model-Based Inference of Synaptic Transmission
Bykowska, O., Gontier, C., Sax, A.-L., Jia, D. W., Montero, M. L., Bird, A. D., Houghton, C. J., Pfister, J.-P., & Costa, R. P. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00021 · Cited by 23
Jiang, S., Xiao, L., Sun, Y., He, M., Gao, C., Zhu, C., Chang, H., Ding, J., Li, W., Wang, Y., et al. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12670 · Cited by 23
Protein Biomarkers for in Vitro Testing of Embryotoxicity
Groebe, K., Hayeß, K., Klemm-Manns, M., Schwall, G., Woźny, W., Steemans, M., Peters, A. K., Sastri, C., Jaeckel, P., Stegmann, W., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100514e · Cited by 23
Biswas, M. S., Roy, S. K., Hasan, R., & Pk, M. M. U. (2024) · Health Science Reports · doi:10.1002/hsr2.2233 · Cited by 24
Jannati, A., Ryan, M. A., Block, G., Kayarian, F. B., Oberman, L. M., Rotenberg, A., & Pascual‐Leone, Á. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.03.021 · Cited by 23
Ansen-Wilson, L. J., & Lipinski, R. J. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.12.002 · Cited by 25
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem
Dubiel, A., & Kulesza, R. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.030 · Cited by 22
Peralta, F. A., Fuentealba, C., Fiedler, J. L., & Aliaga, E. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5529 · Cited by 21
Murawski, N. J., Brown, K. L., & Stanton, M. E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.020 · Cited by 20
Fuentealba, C., Fiedler, J. L., Peralta, F. A., Avalos, A. M., Aguayo, F. I., Morgado-Gallardo, K. P., & Aliaga, E. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00261 · Cited by 21
Autism as a Disorder of Altered Global Functional and Structural Connectivity
van Elst, L. T., Riedel, A., & Maier, S. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.003 · Cited by 18
Pérez, C., Sawmiller, D. R., & Tan, J. (2016) · Neural Development · doi:10.1186/s13064-016-0066-x · Cited by 19
Schiavi, S., Rosa, P. L., Petrillo, S., Carbone, E., D’Amico, J., Piemonte, F., & Trezza, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.851679 · Cited by 19
Two-legged hopping in autism spectrum disorders
Moran, M. F., Foley, J. T., Parker, M. E., & Weiss, M. J. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00014 · Cited by 22
Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment
Norton, S. A., Gifford, J. J., Pawlak, A. P., Derbaly, A., Sherman, S. L., Zhang, H., Wagner, G. C., & Kusnecov, A. W. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.029 · Cited by 17
Jiang, S., He, M., Xiao, L., Sun, Y., Ding, J., Li, W., Guo, B., Wang, L., Wang, Y., Gao, C., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.835993 · Cited by 19
Triyasakorn, K., Ubah, U. D. B., Roan, B., Conlin, M., Aho, K. A., & Awale, P. S. (2022) · Toxics · doi:10.3390/toxics10070379 · Cited by 15
Allen, S. J., & Morishita, H. (2024) · Science Advances · doi:10.1126/sciadv.adh3920 · Cited by 13
Lemmens, M. A. M., Steinbusch, H. W. M., Rutten, B. P. F., & Schmitz, C. (2010) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2010.06.005 · Cited by 13
Dreier, J. W., Christensen, J., Igland, J., Gissler, M., Leinonen, M. K., Vegrim, H. M., Sun, Y., Tomson, T., Zoëga, H., Bjørk, M., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.56425 · Cited by 13
King, C., Rogers, L. G., Jansen, J., Sivayokan, B., Neyhard, J., Warnes, E., Hall, S. E., & Plakke, B. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114638 · Cited by 16
Adıgüzel, E., Bozkurt, N. M., & Ünal, G. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2239575 · Cited by 12
Early valproic acid exposure alters functional organization in the primary visual cortex
Pohl‐Guimarães, F., Krahe, T. E., & Medina, A. E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.025 · Cited by 12
D’Antoni, S., Schiavi, S., Buzzelli, V., Giuffrida, S., Feo, A., Ascone, F., Busceti, C. L., Nicoletti, F., Trezza, V., & Catania, M. V. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06457-w · Cited by 11
Genetic influences of autism candidate genes on circuit wiring and olfactory decoding
Hartig, R., Wolf, D., Schmeißer, M. J., & Kelsch, W. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03390-8 · Cited by 11
Gouda, B., Sinha, S. N., Sangaraju, R., Huynh, T. T., Shashikala, P., Mullapudi, S. V., Mungamuri, S. K., Patil, P. B., & Periketi, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34992 · Cited by 11
Anshu, K., Nair, A. K., Srinath, S., & Laxmi, T. R. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05684-y · Cited by 12
Salari, Z., Moslemizadeh, A., Tezerji, S. S., Sabet, N., parizi, A. S., Khaksari, M., Sheibani, V., Jafari, E., Shafieipour, S., & Bashiri, H. (2024) · Birth Defects Research · doi:10.1002/bdr2.2310 · Cited by 10
Berdaa-Sahel, A., Ceschin, R. C., Badaly, D., Lewis, M., Lee, V., Wallace, J., Weinberg, J. G., Schmithorst, V. J., Lo, C. W. Y., & Panigrahy, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165264 · Cited by 9
Persico, A. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00045-5 · Cited by 9
Mali, I., Payne, M. M., King, C., Maze, T., Davison, T., Challans, B., Bossmann, S. H., & Plakke, B. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148199 · Cited by 9
Rahdar, M., Hajisoltani, R., Davoudi, S., Karimi, S. A., Borjkhani, M., Khatibi, V. A., Hosseinmardi, N., Behzadi, G., & Janahmadi, M. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148013 · Cited by 8
Environmental Factors and Autism Spectrum Disorder
Persico, A. M., & Merelli, S. (2015) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000363611 · Cited by 9
Huntingtin gene CAG repeat size affects autism risk: Family‐based and case–control association study
Piras, I. S., Picinelli, C., Iennaco, R., Baccarin, M., Castronovo, P., Tomaiuolo, P., Cucinotta, F., Ricciardello, A., Turriziani, L., Nanetti, L., et al. (2020) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32806 · Cited by 8
O uso de ácido valproico para a indução de modelos animais de autismo: uma revisão
Schlickmann, E., & Fortunato, J. J. (2013) · Jornal Brasileiro de Psiquiatria · doi:10.1590/s0047-20852013000200009 · Cited by 7
Pal, T., Laloli, K. J., Moscrip, C., Olszewski, P. K., & Klockars, A. (2022) · Genes · doi:10.3390/genes13020259 · Cited by 7
Mann, R. S., Allman, B. L., & Schmid, S. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00029.2022 · Cited by 6
Liu, C., Guo, Z., Pang, J., Zhang, Y., Yang, Z., Cao, J., & Zhang, T. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115052 · Cited by 6
Serotonin Dysfunction in Autism
Blue, M. E., Johnston, M. V., Moloney, C. B., & Höhmann, C. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-489-0_5 · Cited by 6
Sunand, K., Mohan, G. K., & Bakshi, V. (2020) · International Journal of Applied Pharmaceutical Sciences and Research · doi:10.21477/ijapsr.5.1.3 · Cited by 6
Structure and dynamics of the neocortical microcircuit connectivity
Bé, J.-V. L. (2007) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-3802 · Cited by 4
Cacciato‐Salcedo, S., Lao-Rodríguez, A. B., & Malmierca, M. S. (2026) · Communications Biology · doi:10.1038/s42003-026-09585-z · Cited by 4
Schneider, T., & Przewo̵cki, R. (2011) · InTech eBooks · doi:10.5772/20391 · Cited by 2
Craeghs, L., Callaerts‐Vegh, Z., Verslegers, M., der Jeugd, A. V., Govaerts, K., Dresselaers, T., Wogensen, E., Verreet, T., Moons, L., Benotmane, M. A., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab431 · Cited by 4
Nissen, M., Buehler, S., Stubbe, M., & Gimsa, J. (2016) · Biosystems · doi:10.1016/j.biosystems.2016.04.009 · Cited by 3
Traetta, M. E., Codagnone, M. G., Litvak, E., Corpa, M. J. M., Uccelli, N. A., Zárate, S., & Reinés, A. G. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111591 · Cited by 2
Valproic Acid Accelerates Neural Outgrowth during Dorsal Root Ganglia Neurogenesis In Vitro
Wiens, D. J., Bergan, H. M., Walter, O. S., McGinley, A., & Ahlrichs, B. (2019) · Annals of Behavioral Neuroscience · doi:10.18314/abne.v2i1.1607 · Cited by 1
Sivayokan, B., King, C., Mali, I., Payne, M. M., Strating, H., Warnes, E., Bossmann, S. H., & Plakke, B. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115136 · Cited by 2
Altered neocortical microcircuitry in the valproic acid rat model of autism
Rinaldi, T. (2006) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-3701 · Cited by 2
Self-citationRezaei, E., & Biology, P. C. I. A. (2020) · SRPH Journal of Fundamental Sciences and Technology · doi:10.29252/sjfst.2.1.1 · Cited by 2
Complex Neurodevelopmental Disorders And Their Genetic Etiologies
Batool, A., & Arooj, M. (2016) · International journal of scientific and technology research · Cited by 1
Xiao, X., Ai, R., Tian, Y., Mi, N., Liu, W., Cheng, S., Qian, N., & Zhu, X. (2021) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.spl.343 · Cited by 1
Pathological Synaptic Plasticity in Neurological Disorders
Jin, C., & Karlstedt, K. (2025) · Synaptic Plasticity - Neurobiology, Neuroanatomy, and Clinical Neuroscience · doi:10.5772/intechopen.1007753 · Cited by 1
Prince, P. D., Codagnone, M. G., Opezzo, J. A. W., Areán, J. S. A., Höcht, C., Arnal, N., Álvarez, S., Zárate, S., & Reinés, A. G. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06899-4 · Cited by 3
Translational neuroscience requires better design and analysis of preclinical studiesPreprint
Lazic, S. E. (2012) · Nature Precedings · doi:10.1038/npre.2012.6987.1 · Cited by 1
Lawler, C. P., & Halladay, A. K. (2010) · Wiley eBooks · doi:10.1002/9780470917060.ch10
ANTI-EPILEPTIC DRUGS AND BRAIN AND BEHAVIOURAL DEVELOPMENT IN ANIMAL MODELS AND HUMANS
Adab, N., & O’Donoghue, M. (2010) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539510000100
Experimental Models for Autism Spectrum Disorder Follow-Up for the Validity
Devi, U., Kumar, V., Gupta, P. S., Dubey, S., Singh, M., Gautam, S., Rawat, J. K., Roy, S., Yadav, R. K., Ansari, M. N., et al. (2016) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-016-0088-7
Sensory Filtering and Cognitive Function in a Valproic Acid Rat Model of Autism
Silva, D., & Theshani, A. (2016) · Scholarship@Western (Western University)
Pickup, S. (2009) · Syracuse University Libraries (Syracuse University)
Cezar, L. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2022.tde-20012023-112002
Ueno, H., Iyanaga, Y., Kunida, K., Hara, Y., Miura, H., Nakai, Y., Tanuma, M., Hayashida, M., Yokoyama, R., Ohkubo, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-05996-w
Sowers, L. P., Russo, A. F., Bassuk, A. G., Wemmie, J. A., Gonzalez, P., & Bonthius, D. (2012) · doi:10.17077/etd.ks0p5kv0
Autisme et cervelet : le gradient des ions chlorures en question
Roux, S. (2018) · theses.fr (ABES) · doi:10.70675/a6f075d7ze2f7z4136z8b39zdeb288b0b7a3
Li, Z., Sun, Y., Huo, X., Ren, X., Ding, N., Qian, X., Li, A., & Sun, T. (2026) · Neural Plasticity · doi:10.1155/np/4005949
Matsumuro, M., Ichinose, S., & Iwasaki, H. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.08.014
Neuronale Schaltkreise als kleinste Einheit kortikaler Netzwerke – Struktur und Funktion
Feldmeyer, D. (2011) · Springer eBooks · doi:10.1007/978-3-642-25476-5_3
Metadata
- Authors
- Rinaldi, T., Silberberg, G., & Markram, H.
- Affiliations
- Karolinska Institutet (SE)
- École Polytechnique Fédérale de Lausanne (CH)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07-17
- Volume
- 18
- Issue
- 4
- Pages
- 763-770
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2148788336
- Cited by
- 184
- References
- 31
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 16 · 2015: 20 · 2014: 10 · 2013: 17 · 2012: 7
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- valproic acid, prenatal drug exposure, teratogenicity, autism spectrum disorder, recurrent connectivity, pyramidal neurons, intrinsic excitability, synaptic transmission, layer 5 pyramidal neurons
- MeSH terms
- Animals, Anticonvulsants, Autistic Disorder, Cell Count, Disease Models, Animal, Female, Male, Neural Pathways, Organ Culture Techniques, Pregnancy, Prenatal Exposure Delayed Effects, Valproic Acid, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Neocortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review