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Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid
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Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryonic exposure to VPA on microcircuit properties of juvenile rat neocortex using in vitro electrophysiology. We found that a single prenatal injection of VPA on embryonic day 11.5 causes a significant enhancement of the local recurrent connectivity formed by neocortical pyramidal neurons. The study of the biophysical properties of these connections revealed weaker excitatory synaptic responses. A marked decrease of the intrinsic excitability of pyramidal neurons was also observed. Furthermore, we demonstrate a diminished number of putative synaptic contacts in connection between layer 5 pyramidal neurons. Local hyperconnectivity may render cortical modules more sensitive to stimulation and once activated, more autonomous, isolated, and more difficult to command. This could underlie some of the core symptoms observed in humans prenatally exposed to valproic acid.
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“In the case of apical dendrites, complexity, but not length, is increased on layer II pyramidal neurons in the motor cortex [331], decreased in the medial PFC [297], or is unchanged in layer V pyramidal neurons of the somatosensory cortex following VPA exposure in rodents [301].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [301]
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Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,634
Self-citationJust, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589
Castelli, F. (2002) · Brain · doi:10.1093/brain/awf189 · Cited by 1,377
Autism and Abnormal Development of Brain Connectivity: Figure 1.
Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217
Differential signaling via the same axon of neocortical pyramidal neurons
Markram, H., Wang, Y., & Tsodyks, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5323 · Cited by 1,102
Self-citationMarkram, H., Lübke, J., Frotscher, M., Roth, A., & Sakmann, B. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022031 · Cited by 960
Self-citationBehavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
Schneider, T., & Przewłocki, R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300518 · Cited by 959
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846
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Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., Ailamaki, A., Alonso-Nanclares, L., Antille, N., Arsever, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.029 · Cited by 1,557
Self-citationIncreased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765
Bourgeron, T. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.003 · Cited by 637
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Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 571
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Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 444
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Markram, H. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.006.2007 · Cited by 394
Self-citationPrenatal exposure to drugs: effects on brain development and implications for policy and education
Thompson, B. L., Levitt, P. R., & Stanwood, G. D. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2598 · Cited by 379
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Samson, F., Mottron, L., Soulières, I., & Zeffiro, T. A. (2012) · Human Brain Mapping · doi:10.1002/hbm.21307 · Cited by 351
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Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., Shin, C. Y., & Ko, K. H. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.018 · Cited by 292
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Kana, R. K., Libero, L. E., & Moore, M. S. (2011) · Physics of Life Reviews · doi:10.1016/j.plrev.2011.10.001 · Cited by 263
Lazic, S. E., & Essioux, L. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-37 · Cited by 260
Rinaldi, T. (2008) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.004.2008 · Cited by 210
Tatti, R., Haley, M. S., Swanson, O. K., Tselha, T., & Maffei, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.017 · Cited by 223
Roullet, F., Wollaston, L., deCatanzaro, D., & Foster, J. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.069 · Cited by 213
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Self-citationLazic, S. E., & Essioux, L. (2016) · Cited by 182
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Brumback, A. C., Ellwood, I. T., Kjærby, C., Iafrati, J., Robinson, S., Lee, A. T., Patel, T., Nagaraj, S., Davatolhagh, M. F., & Sohal, V. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.213 · Cited by 162
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Favre, M., Barkat, T. R., Mendola, D. L., Khazen, G., Markram, H., & Markram, H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00088 · Cited by 152
Self-citationAl-Amin, M. M., Rahman, M., Khan, F. R., Zaman, F., & Reza, H. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.041 · Cited by 135
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Dani, V. S., & Nelson, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-09.2009 · Cited by 124
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Ward, J. (2018) · Cognitive Neuroscience · doi:10.1080/17588928.2018.1557131 · Cited by 134
Codagnone, M. G., Podestá, M. F., Uccelli, N. A., & Reinés, A. (2015) · Developmental Neuroscience · doi:10.1159/000375489 · Cited by 115
Tartaglione, A. M., Schiavi, S., Calamandrei, G., & Trezza, V. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.024 · Cited by 117
Kumar, H., & Sharma, B. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.052 · Cited by 119
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Go, H. S., Kim, K. C., Choi, C. S., Jeon, S. J., Kwon, K. J., Han, S., Lee, J., Cheong, J. H., Ryu, J. H., Kim, C., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.028 · Cited by 110
Qiu, S., Anderson, C. T., Levitt, P., & Shepherd, G. M. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6569-10.2011 · Cited by 106
Garcia-Oscos, F., Salgado, H., Hall, S., Thomas, F., Farmer, G. E., Bermeo, J., Galindo, L. C., Ramirez, R. D., D'Mello, S., Rose-John, S., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.018 · Cited by 105
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Sowers, L. P., Loo, L., Wu, Y. C., Campbell, E., Ulrich, J. D., Wu, S., Paemka, L., Wassink, T. H., Meyer, K. J., Bing, X., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.71 · Cited by 95
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Pratt, K. G., & Khakhalin, A. S. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012138 · Cited by 94
Pragnya, B., Kameshwari, J. S. L., & Veeresh, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.045 · Cited by 88
Kang, J., & Kim, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00017 · Cited by 82
Kumar, H., Sharma, B. M., & Sharma, B. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.007 · Cited by 86
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Main, S. L., & Kulesza, R. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.052 · Cited by 80
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Costa, R. P., Sjöström, P. J., & van Rossum, M. C. W. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00075 · Cited by 75
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Shepherd, G. M., & Katz, D. M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.006 · Cited by 75
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Kessler, K., Seymour, R. A., & Rippon, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.002 · Cited by 69
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Martin, H. G. S., Lassalle, O., Brown, J. T., & Manzoni, O. J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv031 · Cited by 63
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Kinast, K., Peeters, D., Kolk, S. M., Schubert, D., & Homberg, J. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00072 · Cited by 57
Fereshetyan, K., Chavushyan, V. A., Danielyan, M., & Yenkoyan, K. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-02994-6 · Cited by 58
Cohen, O. S., Varlinskaya, E. I., Wilson, C., Glatt, S. J., & Mooney, S. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.09.002 · Cited by 57
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Kelley, D. J., Bhattacharyya, A., Lahvis, G. P., YIN, J., Malter, J. S., & Davidson, R. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.005 · Cited by 60
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Engineer, C. T., Centanni, T. M., Im, K. W., Borland, M. S., Moreno, N. A., Carraway, R. S., Wilson, L. G., & Kilgard, M. P. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22175 · Cited by 55
Judson, M. C., Eagleson, K. L., Wang, L., & Levitt, P. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22467 · Cited by 57
Kuo, H., & Liu, F. (2017) · The FASEB Journal · doi:10.1096/fj.201700054r · Cited by 54
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Liu, Q., Lee, E., & Davis, R. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.065 · Cited by 51
(2015) · Europe PMC (PubMed Central) · Cited by 51
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Silberberg, G. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.08.009 · Cited by 46
Self-citationZhang, R., Zhou, J., Ren, J., Sun, S., Di, Y., Wang, H., An, X., Zhang, K., Zhang, J., Qian, Z., et al. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.01.008 · Cited by 47
Kuo, H., & Liu, F. (2022) · Biomedicines · doi:10.3390/biomedicines10030560 · Cited by 50
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James, E. J., Gu, J., Ramirez-Vizcarrondo, C. M., Hasan, M., Truszkowski, T. L. S., Tan, Y., Oupravanh, P. M., Khakhalin, A. S., & Aizenman, C. D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4050-14.2015 · Cited by 47
Ramaswamy, S., Hill, S., King, J. G., Schürmann, F., Wang, Y., & Markram, H. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219576 · Cited by 42
Self-citationWu, H.-F., Chen, P. S., Chen, Y., Chi-Wei, L., Chen, I.-T., & Lin, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0074-1 · Cited by 44
Kroon, T., Sierksma, M. C., & Meredith, R. M. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00075 · Cited by 45
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Kumamaru, E., Egashira, Y., Takenaka, R., & Takamori, S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.03.066 · Cited by 41
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Lee, K. C., Mills, Z., Cheung, P. Y., Cheyne, J. E., & Montgomery, J. M. (2022) · Pharmaceuticals · doi:10.3390/ph16010001 · Cited by 42
Port, R. G., Gandal, M. J., Roberts, T. P. L., Siegel, S. J., & Carlson, G. C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00414 · Cited by 41
Brown, E., Lautz, J. D., Davis, T. R., Gniffke, E. P., VanSchoiack, A., Neier, S. C., Tashbook, N., Nicolini, C., Fahnestock, M. L., Schrum, A. G., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0229-1 · Cited by 42
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Crandall, J. E., Goodman, T. H., McCarthy, D. M., Duester, G., Bhide, P. G., Dräger, U. C., & McCaffery, P. J. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07471.x · Cited by 43
Zimmerman, R., Smith, A., Fech, T., Mansour, Y., & Kulesza, R. J. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05729-7 · Cited by 37
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Walcott, E. C., Higgins, E. A., & Desai, N. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1341-11.2011 · Cited by 36
Favre, M., Mendola, D. L., Meystre, J., Christodoulou, D., Cochrane, M. J., Markram, H., & Markram, H. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00127 · Cited by 40
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Testa-Silva, G. (2009) · Frontiers in Synaptic Neuroscience · doi:10.3389/neuro.19.001.2009 · Cited by 39
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Felix‐Ortiz, A. C., & Febo, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037313 · Cited by 34
Degnan, A. J., Wisnowski, J. L., Choi, S., Ceschin, R. C., Bhushan, C., Leahy, R. M., Corby, P. M. A., Schmithorst, V. J., & Panigrahy, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130686 · Cited by 37
Heeger, D. J., Behrmann, M., & Dinstein, I. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.019 · Cited by 32
Adjimann, T. S., Argañaraz, C., & Soiza‐Reilly, M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01388-6 · Cited by 34
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Yamamuro, K., Yoshino, H., Ogawa, Y., Okamura, K., Nishihata, Y., Makinodan, M., Saito, Y., & Kishimoto, T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00105 · Cited by 29
Metadata
- Authors
- Rinaldi, T., Silberberg, G., & Markram, H.
- Affiliations
- Karolinska Institutet (SE)
- École Polytechnique Fédérale de Lausanne (CH)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07-17
- Volume
- 18
- Issue
- 4
- Pages
- 763-770
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2148788336
- Cited by
- 184
- References
- 31
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 16 · 2015: 20 · 2014: 10 · 2013: 17 · 2012: 7
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- valproic acid, prenatal drug exposure, teratogenicity, autism spectrum disorder, recurrent connectivity, pyramidal neurons, intrinsic excitability, synaptic transmission, layer 5 pyramidal neurons
- MeSH terms
- Animals, Anticonvulsants, Autistic Disorder, Cell Count, Disease Models, Animal, Female, Male, Neural Pathways, Organ Culture Techniques, Pregnancy, Prenatal Exposure Delayed Effects, Valproic Acid, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Neocortex, Rats
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