The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans
Open accessAbstract
Nausea is a universal human experience. It evolves slowly over time, and brain mechanisms underlying this evolution are not well understood. Our functional magnetic resonance imaging (fMRI) approach evaluated brain activity contributing to and arising from increasing motion sickness. Subjects rated transitions to increasing nausea, produced by visually induced vection within the fMRI environment. We evaluated parametrically increasing brain activity 1) precipitating increasing nausea and 2) following transition to stronger nausea. All subjects demonstrated visual stimulus-associated activation (P < 0.01) in primary and extrastriate visual cortices. In subjects experiencing motion sickness, increasing phasic activity preceding nausea was found in amygdala, putamen, and dorsal pons/locus ceruleus. Increasing sustained response following increased nausea was found in a broader network including insular, anterior cingulate, orbitofrontal, somatosensory and prefrontal cortices. Moreover, sustained anterior insula activation to strong nausea was correlated with midcingulate activation (r = 0.87), suggesting a closer linkage between these specific regions within the brain circuitry subserving nausea perception. Thus, while phasic activation in fear conditioning and noradrenergic brainstem regions precipitates transition to strong nausea, sustained activation following this transition occurs in a broader interoceptive, limbic, somatosensory, and cognitive network, reflecting the multiple dimensions of this aversive commonly occurring symptom.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recently, the brain areas active during the development of nausea have been identified in imaging studies (Napadow et al. 2013; Sugiyama et al. 2011; Suzuki et al. 2012; Yates 1996a, b; Yates et al. 1995a, b; Yates and Bronstein 2005; Yates and Miller 2009).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Napadow et al. 2013
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
(2001) · doi:10.1017/cbo9780511546396 · Cited by 4,482
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406
Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging
Beckmann, C. F., & Smith, S. M. (2004) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2003.822821 · Cited by 2,707
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
Pain and emotion interactions in subregions of the cingulate gyrus
Vogt, B. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1704 · Cited by 1,810
Research works printed but not linked: 3
- Hu, 1999, Aviation, Space, and Environmental Medicine, 70, 759
- 1993, INT SYMP AVIAT PSYCHOL, 7, 799
- Lacount, 2009, 36, 49
Cited by
Sorted by citations
Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior
Betley, J. N., Cao, Z. F. H., Ritola, K., & Sternson, S. M. (2013) · Cell · doi:10.1016/j.cell.2013.11.002 · Cited by 591
“We found that the PVH receives input from the midcingulate cortex, a region associated with the experience of negative visceral states (Napadow et al., 2013).”
Motion sickness: more than nausea and vomiting
Lackner, J. R. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4008-8 · Cited by 314
“Recently, the brain areas active during the development of nausea have been identified in imaging studies (Napadow et al. 2013; Sugiyama et al. 2011; Suzuki et al. 2012; Yates 1996a, b; Yates et al. 1995a, b; Yates and Bronstein 2005; Yates and Miller 2009).”
BackgroundVirtual Reality Is Sexist: But It Does Not Have to Be
Stanney, K. M., Fidopiastis, C., & Foster, L. (2020) · Frontiers in Robotics and AI · doi:10.3389/frobt.2020.00004 · Cited by 318
Farr, O. M., Sofopoulos, M., Tsoukas, M. A., Dincer, F., Thakkar, B., Sahin-Efe, A., Filippaios, A., Bowers, J., Srnka, A., Gavrieli, A., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3874-y · Cited by 287
“We also report changes in activation in sensorimotor areas, including the cingulate, superior frontal and somatosensory cortex, which are often linked with feelings of nausea [29, 30].”
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
Horn, C. C., Wallisch, W. J., Homanics, G. E., & Williams, J. P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.037 · Cited by 304
“Furthermore, during sustained nausea the insular, cingulate, orbitofrontal, and prefrontal cortices were also recruited (Napadow et al., 2013).”
Background
Metadata
- Authors
- Napadow, V., Sheehan, J. D., Kim, J., LaCount, L. T., Park, K., Kaptchuk, T. J., Rosen, B. R., & Kuo, B.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Kyung Hee University (KR)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-02
- Volume
- 23
- Issue
- 4
- Pages
- 806-813
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC3593575
- OpenAlex
- W2147691780
- Semantic Scholar
- 0a06a06e294f3469f9768684508df0ae84ee9339
- Cited by
- 215
- References
- 55
- Citations by year
- 2026: 20 · 2025: 7 · 2024: 12 · 2023: 14 · 2022: 14 · 2021: 11 · 2020: 18 · 2019: 19 · 2018: 14 · 2017: 15 · 2016: 27 · 2015: 14 · 2014: 14 · 2013: 13 · 2012: 2
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK069614)
- National Center for Research Resources (P41-RR-14075, UL1RR025758, P41RR014075)
- National Center for Complementary and Integrative Health (R01AT004714, F05AT003770, K24AT004095, K01AT002166, P01AT002048)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Keywords
- nausea, motion sickness, brain circuits, amygdala, anterior insula, anterior cingulate cortex, locus coeruleus, interoception, noradrenergic system, fear conditioning, somatosensory cortex, orbitofrontal cortex
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Motion Perception, Nausea, Nerve Net, Neural Pathways, Oxygen, Photic Stimulation, Reaction Time, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
