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The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans
Open accessAbstract
Nausea is a universal human experience. It evolves slowly over time, and brain mechanisms underlying this evolution are not well understood. Our functional magnetic resonance imaging (fMRI) approach evaluated brain activity contributing to and arising from increasing motion sickness. Subjects rated transitions to increasing nausea, produced by visually induced vection within the fMRI environment. We evaluated parametrically increasing brain activity 1) precipitating increasing nausea and 2) following transition to stronger nausea. All subjects demonstrated visual stimulus-associated activation (P < 0.01) in primary and extrastriate visual cortices. In subjects experiencing motion sickness, increasing phasic activity preceding nausea was found in amygdala, putamen, and dorsal pons/locus ceruleus. Increasing sustained response following increased nausea was found in a broader network including insular, anterior cingulate, orbitofrontal, somatosensory and prefrontal cortices. Moreover, sustained anterior insula activation to strong nausea was correlated with midcingulate activation (r = 0.87), suggesting a closer linkage between these specific regions within the brain circuitry subserving nausea perception. Thus, while phasic activation in fear conditioning and noradrenergic brainstem regions precipitates transition to strong nausea, sustained activation following this transition occurs in a broader interoceptive, limbic, somatosensory, and cognitive network, reflecting the multiple dimensions of this aversive commonly occurring symptom.
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“Recently, the brain areas active during the development of nausea have been identified in imaging studies (Napadow et al. 2013; Sugiyama et al. 2011; Suzuki et al. 2012; Yates 1996a, b; Yates et al. 1995a, b; Yates and Bronstein 2005; Yates and Miller 2009).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Napadow et al. 2013
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Background
Metadata
- Authors
- Napadow, V., Sheehan, J. D., Kim, J., LaCount, L. T., Park, K., Kaptchuk, T. J., Rosen, B. R., & Kuo, B.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Kyung Hee University (KR)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-02
- Volume
- 23
- Issue
- 4
- Pages
- 806-813
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC3593575
- OpenAlex
- W2147691780
- Semantic Scholar
- 0a06a06e294f3469f9768684508df0ae84ee9339
- Cited by
- 215
- References
- 55
- Citations by year
- 2026: 20 · 2025: 7 · 2024: 12 · 2023: 14 · 2022: 14 · 2021: 11 · 2020: 18 · 2019: 19 · 2018: 14 · 2017: 15 · 2016: 27 · 2015: 14 · 2014: 14 · 2013: 13 · 2012: 2
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK069614)
- National Center for Research Resources (P41-RR-14075, UL1RR025758, P41RR014075)
- National Center for Complementary and Integrative Health (R01AT004714, F05AT003770, K24AT004095, K01AT002166, P01AT002048)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Keywords
- nausea, motion sickness, brain circuits, amygdala, anterior insula, anterior cingulate cortex, locus coeruleus, interoception, noradrenergic system, fear conditioning, somatosensory cortex, orbitofrontal cortex
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Motion Perception, Nausea, Nerve Net, Neural Pathways, Oxygen, Photic Stimulation, Reaction Time, Young Adult
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