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Cited by 261Functional Brain Connectivity StudiesNeural dynamics and brain functionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Topologically Reorganized Connectivity Architecture of Default-Mode, Executive-Control, and Salience Networks across Working Memory Task Loads

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Liang, Xia, Zou, Qihong, He, Yong, Yang, Yihong·2016·Cerebral Cortex
DOI 10.1093/cercor/bhu316PMC PMC4785946
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Abstract

The human brain is topologically organized into a set of spatially distributed, functionally specific networks. Of these networks, the default-mode network (DMN), executive-control network (ECN), and salience network (SN) have received the most attention recently for their vital roles in cognitive functions. However, very little is known about whether and how the interactions within and between these 3 networks would be modulated by cognitive demands. Here, we employed graph-based modularity analysis to identify the DMN, ECN, and SN during an N-back working memory (WM) task and further investigated the modulation of intra- and inter-network interactions at different cognitive loads. As the task load elevated, functional connectivity decreased within the DMN while increased within the ECN, and the SN connected more with both the DMN and ECN. Within-network connectivity of the ventral and dorsal posterior cingulate cortex was differentially modulated by cognitive load. Further, the superior parietal regions in the ECN showed increased internetwork connections at higher WM loads, and these increases correlated positively with WM task performance. Together, these findings advance our understanding of dynamic integrations of specialized brain systems in response to cognitive demands and may serve as a baseline for assessing potential disruptions of these interactions in pathological conditions.

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Metadata

Authors
Liang, X., Zou, Q., He, Y., & Yang, Y.
Affiliations
  • National Institutes of Health (US)
  • Peking University (CN)
Corresponding author
Liang, Xia
ORCID
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2015-01-16
Volume
26
Issue
4
Pages
1501-1511
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bhu316
PMC
PMC4785946
OpenAlex
W1968592137
Cited by
261
References
56
Citations by year
2026: 11 · 2025: 31 · 2024: 26 · 2023: 22 · 2022: 19 · 2021: 31 · 2020: 17 · 2019: 24 · 2018: 28 · 2017: 21 · 2016: 25 · 2015: 6
FWCI
16.05
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • Cerebral Cortex (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Natural Science Foundation of China (81201142, 81225012, 31221003, 81030028)
  • National Institutes of Health
  • National Science Fund for Distinguished Young Scholars (81225012)
  • National Institute on Drug Abuse
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
default mode network, frontoparietal network, salience network, working memory, cognitive load, functional connectivity, network topology, posterior cingulate cortex, superior parietal cortex
MeSH terms
Adult, Attention, Brain, Brain Mapping, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neural Pathways, Young Adult, Executive Function

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