Shiga Toxin–Producing Escherichia coli Transmission via Fecal Microbiota Transplant
Abstract
Fecal microbiota transplantation (FMT) is recommended therapy for multiply recurrent Clostridioides difficile infection. We report adverse events in 7 patients who received FMT from a stool donor who was colonized with Shiga toxin–producing Escherichia coli (STEC). No patients died of FMT-transmitted STEC. Improved screening can likely avoid future transmission.
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FMT may carry the risk of unintended introduction of pathogens and antibiotic-resistant microbes into recipients.
“FMT may also carry the risk of unintended introduction of pathogens and antibiotic-resistant microbes into the recipients.749,750”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [750]
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- Authors
- Zellmer, C., Sater, M. R. A., Huntley, M. H., Osman, M., Olesen, S. W., & Ramakrishna, B.
- Affiliations
- OpenBiome (US)
- Day Zero Diagnostics, Allston, Massachusetts, USA
- Corresponding author
- Ramakrishna, Bharat
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-09-29
- Volume
- 72
- Issue
- 11
- Pages
- e876-e880
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W3091185940
- Cited by
- 98
- References
- 12
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 16 · 2023: 22 · 2022: 18 · 2021: 18 · 2020: 1
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- Shiga toxin-producing Escherichia coli, fecal microbiota transplantation, donor screening, Clostridium difficile infection, adverse events
- MeSH terms
- Fecal Microbiota Transplantation, Clostridium Infections, Escherichia coli Infections, Feces, Humans, Clostridioides difficile, Shiga-Toxigenic Escherichia coli, Microbiota
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