Systematic review with meta‐analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection
Open accessAbstract
BACKGROUND: Clostridium difficile infection (CDI) is the commonest nosocomial cause of diarrhoea. Faecal microbiota transplantation (FMT) is an approved treatment for recurrent or refractory CDI but there is uncertainty about its use. AIM: To evaluate the efficacy of FMT in treating recurrent and refractory CDI and investigate outcomes from modes of delivery and preparation. METHODS: A systematic review and meta-analysis was performed. MEDLINE, EMBASE, CINAHL, Cochrane Library, trial registers and conference proceedings were searched. Studies on FMT in recurrent and refractory CDI were included. The primary outcome was clinical resolution with subgroup analyses of modes of delivery and preparation. Random effects meta-analyses were used to combine data. RESULTS: Thirty seven studies were included; seven randomised controlled trials and 30 case series. FMT was more effective than vancomycin (RR: 0.23 95%CI 0.07-0.80) in resolving recurrent and refractory CDI. Clinical resolution across all studies was 92% (95%CI 89%-94%). A significant difference was observed between lower GI and upper GI delivery of FMT 95% (95%CI 92%-97%) vs 88% (95%CI 82%-94%) respectively (P=.02). There was no difference between fresh and frozen FMT 92% (95%CI 89%-95%) vs 93% (95%CI 87%-97%) respectively (P=.84). Administering consecutive courses of FMT following failure of first FMT resulted in an incremental effect. Donor screening was consistent but variability existed in recipient preparation and volume of FMT. Serious adverse events were uncommon. CONCLUSION: Faecal microbiota transplantation is an effective treatment for recurrent and refractory Clostridium difficile infection, independent of preparation and route of delivery.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544 · see citing works
Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
A Nonparametric “Trim and Fill” Method of Accounting for Publication Bias in Meta-Analysis
Duval, S., & Tweedie, R. (2000) · Journal of the American Statistical Association · doi:10.1080/01621459.2000.10473905 · Cited by 2,955 · see citing works
Interpretation of random effects meta-analyses
Riley, R. D., Higgins, J. P. T., & Deeks, J. J. (2011) · BMJ · doi:10.1136/bmj.d549 · Cited by 2,884 · see citing works
Transformations Related to the Angular and the Square Root
Freeman, M. F., & Tukey, J. W. (1950) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177729756 · Cited by 2,634 · see citing works
A Re-Evaluation of Random-Effects Meta-Analysis
Higgins, J. P. T., Thompson, S. G., & Spiegelhalter, D. J. (2009) · Journal of the Royal Statistical Society Series A: Statistics in Society · doi:10.1111/j.1467-985x.2008.00552.x · Cited by 2,569 · see citing works
Moayyedi, P., Surette, M. G., Kim, P. T., Libertucci, J., Wolfe, M., Onischi, C., Armstrong, D., Marshall, J. K., Kassam, Z., Reinisch, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.001 · Cited by 1,499 · see citing works
Treating Clostridium difficile infection with fecal microbiota transplantation
Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.014 · Cited by 1,003 · see citing works
(1958) · PubMed · Cited by 978 · see citing works
Rossen, N. G., Fuentes, S., van der Spek, M. J., Tijssen, J. G., Hartman, J. H. A., Duflou, A., Löwenberg, M., van den Brink, G. R., Mathus-Vliegen, E. M. H., de Vos, W. M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.03.045 · Cited by 921 · see citing works
Kassam, Z., Lee, C. H., Yuan, Y., & Hunt, R. H. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.59 · Cited by 904 · see citing works
Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J., & Khoruts, A. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.482 · Cited by 738 · see citing works
Petrof, E. O., Gloor, G. B., Vanner, S. J., Weese, S. J., Carter, D., Daigneault, M. C., Brown, E. M., Schroeter, K., & Allen-Vercoe, E. (2013) · Microbiome · doi:10.1186/2049-2618-1-3 · Cited by 731 · see citing works
Brandt, L. J., Aroniadis, O. C., Mellow, M., Kanatzar, A., Kelly, C., Park, T., Stollman, N., Rohlke, F., & Surawicz, C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.60 · Cited by 672 · see citing works
Kelly, C. R., Ihunnah, C., Fischer, M., Khoruts, A., Surawicz, C., Afzali, A., Aroniadis, O., Barto, A., Borody, T., Giovanelli, A., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.133 · Cited by 636 · see citing works
Youngster, I., Russell, G. H., Pindar, C., Ziv-Baran, T., Sauk, J., & Hohmann, E. L. (2014) · JAMA · doi:10.1001/jama.2014.13875 · Cited by 629 · see citing works
Lee, C. H., Steiner, T., Petrof, E. O., Smieja, M., Roscoe, D., Nematallah, A., Weese, J. S., Collins, S., Moayyedi, P., Crowther, M., et al. (2016) · JAMA · doi:10.1001/jama.2015.18098 · Cited by 627 · see citing works
Kelly, C. R., Khoruts, A., Staley, C. M., Sadowsky, M. J., Abd, M., Alani, M. A., Bakow, B. R., Curran, P., McKenney, J. L., Tisch, A., et al. (2016) · Annals of Internal Medicine · doi:10.7326/m16-0271 · Cited by 613 · see citing works
Cammarota, G., Masucci, L., Ianiro, G., Bibbò, S., Dinoi, G., Costamagna, G., Sanguinetti, M., & Gasbarrini, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13144 · Cited by 558 · see citing works
Aas, J., Gessert, C. E., & Bakken, J. (2003) · Clinical Infectious Diseases · doi:10.1086/367657 · Cited by 514 · see citing works
Youngster, I., Sauk, J., Pindar, C., Wilson, R. G., Kaplan, J. L., Smith, M. B., Alm, E. J., Gevers, D., Russell, G. H., & Hohmann, E. L. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu135 · Cited by 467 · see citing works
Fecal Microbiota Transplantation for Clostridium difficile Infection
Drekonja, D. M., Reich, J., Gezahegn, S., Greer, N. L., Shaukat, A., MacDonald, R. H., Rutks, I., & Wilt, T. J. (2015) · Annals of Internal Medicine · doi:10.7326/m14-2693 · Cited by 371 · see citing works
Mattila, E., Uusitalo–Seppälä, R., Wuorela, M., Lehtola, L., Nurmi, H., Ristikankare, M., Moilanen, V., Salminen, K., Seppälä, M., Mattila, P. S., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.037 · Cited by 371 · see citing works
Mullane, K. M., Miller, M. A., Weiss, K., Lentnek, A. L., Golan, Y., Sears, P. S., Shue, Y., Louie, T., & Gorbach, S. L. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir404 · Cited by 245 · see citing works
Orenstein, R., Dubberke, E., Hardi, R., Ray, A., Mullane, K., Pardi, D. S., & Ramesh, M. S. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ938 · Cited by 197 · see citing works
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles
Allegretti, J. R., Kearney, S. M., Li, N., Bogart, E., Bullock, K. H., Gerber, G. K., Bry, L., Clish, C. B., Alm, E. J., & Korzenik, J. R. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13616 · Cited by 193 · see citing works
Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection in 26 Patients
Kelly, C. R., de Leon, L., & Jasutkar, N. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318234570b · Cited by 189 · see citing works
Agrawal, M., Aroniadis, O. C., Brandt, L. J., Kelly, C., Freeman, S., Surawicz, C., Broussard, E., Stollman, N., Giovanelli, A., Smith, B., et al. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000410 · Cited by 186 · see citing works
Yoon, S. S., & Brandt, L. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dac035 · Cited by 178 · see citing works
Fecal Flora Reconstitution for Recurrent Clostridium difficile Infection: Results and Methodology
Rohlke, F., Surawicz, C. M., & Stollman, N. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dadb10 · Cited by 165 · see citing works
Li, Y., Cai, H., Wang, Z.-H., Xu, J., & Fang, J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13492 · Cited by 156 · see citing works
Satokari, R., Mattila, E., Kainulainen, V., & Arkkila, P. (2015) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.13009 · Cited by 150 · see citing works
Costello, S. P., Conlon, M. A., Vuaran, M. S., Roberts-Thomson, I. C., & Andrews, J. M. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13366 · Cited by 141 · see citing works
Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series
MacConnachie, A., Fox, R., Kennedy, D., & Seaton, R. A. (2009) · QJM · doi:10.1093/qjmed/hcp118 · Cited by 137 · see citing works
Rubin, T. A., Gessert, C. E., Aas, J., & Bakken, J. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.11.004 · Cited by 135 · see citing works
Fecal Transplant via Retention Enema for Refractory or Recurrent Clostridium difficile Infection
Kassam, Z. (2012) · Archives of Internal Medicine · doi:10.1001/archinte.172.2.191 · Cited by 128 · see citing works
Khanna, S., Montassier, E., Schmidt, B. A., Patel, R., Knights, D., Pardi, D. S., & Kashyap, P. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13750 · Cited by 125 · see citing works
Garborg, K. K., Waagsbø, B., Stallemo, A., Matre, J., & Sundøy, A. (2010) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2010.499541 · Cited by 124 · see citing works
Fischer, M., Kao, D. H., Mehta, S. R., Martin, T., Dimitry, J., Keshteli, A. H., Cook, G. K., Phelps, E. L., Sipe, B. W., Xu, H., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.180 · Cited by 124 · see citing works
Consensus report: faecal microbiota transfer – clinical applications and procedures
König, J., Siebenhaar, A., Högenauer, C., Arkkila, P. E. T., Nieuwdorp, M., Norén, T., Ponsioen, C. Y., Rosien, U., Rossen, N., Satokari, R. M., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13868 · Cited by 114 · see citing works
Lee, C. H., Belanger, J., Kassam, Z., Smieja, M., Higgins, D., Broukhanski, G., & Kim, P. T. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2088-9 · Cited by 105 · see citing works
Wadhwa, A., Alnahhas, M. F., Dierkhising, R., Patel, R., Kashyap, P., Pardi, D. S., Khanna, S., & Grover, M. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13737 · Cited by 102 · see citing works
Mullane, K. M., Lee, C., Bressler, A. M., Buitrago, M. I., Weiss, K., Dabovic, K., Præstgaard, J., Leeds, J. A., Blais, J., & Pertel, P. E. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04251-14 · Cited by 101 · see citing works
Aroniadis, O. C., Brandt, L. J., Greenberg, A., Borody, T. J., Kelly, C. R., Mellow, M., Surawicz, C. M., Cagle, L. A., Neshatian, L., Stollman, N., et al. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000374 · Cited by 98 · see citing works
Dutta, S., Girotra, M., Garg, S., Dutta, A., von Rosenvinge, E. C., Maddox, C., Song, Y., Bartlett, J. G., Vinayek, R., & Fricke, W. F. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.12.032 · Cited by 81 · see citing works
Treatment of recurrent Clostridium difficile infection: a systematic review
O’Horo, J. C., Jindai, K., Kunzer, B., & Safdar, N. (2013) · Infection · doi:10.1007/s15010-013-0496-x · Cited by 79 · see citing works
Zainah, H., Hassan, M. M., Sroujieh, L., Hassan, S., Alangaden, G. J., & Ramesh, M. S. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3296-y · Cited by 78 · see citing works
Kronman, M. P., Nielson, H., Adler, A. L., Giefer, M. J., Wahbeh, G. T., Singh, N., Zerr, D. M., & Suskind, D. L. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000545 · Cited by 76 · see citing works
Antibiotic treatment for Clostridium difficile-associated diarrhea in adults
Nelson, R. L. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004610.pub3 · Cited by 71 · see citing works
Emanuelsson, F., Claesson, B. E. B., Ljungström, L., Tvede, M., & Ung, K. (2013) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2013.858181 · Cited by 67 · see citing works
Patel, N. C., Griesbach, C. L., DiBaise, J. K., & Orenstein, R. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.04.022 · Cited by 58 · see citing works
LaCourse, S. M., Chester, F. M., Preidis, G. A., McCrary, L. M., Arscott‐Mills, T., James, G., McCollum, E. D., & Hosseinipour, M. C. (2014) · Cited by 57 · see citing works
Treatment of relapsing Clostridium difficile infection using fecal microbiota transplantation
Enuh, H., Pathak, R., Patel, A. A., & Wickremesinghe, P. C. (2013) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s53410 · Cited by 41 · see citing works
Antibiotic treatment for Clostridium difficile-associated diarrhea in adults
Bricker, E., Garg, R., Nelson, R. C., Loza, A., Novak, T., & Hansen, J. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004610 · Cited by 40 · see citing works
Mandalia, A. B., Ward, A., Tauxe, W. M., Kraft, C. S., & Dhere, T. (2015) · International Journal of Colorectal Disease · doi:10.1007/s00384-015-2396-2 · Cited by 34 · see citing works
Khan, M. A., Sofi, A. A., Ahmad, U., Alaradi, O., Khan, A. R., Hammad, T. A., Pratt, J., Sodeman, T. C., Sodeman, W. A., Kamal, S., et al. (2014) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2014/695029 · Cited by 27 · see citing works
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Allegretti, J. R., Korzenik, J. R., & Hamilton, M. J. (2014) · Journal of Visualized Experiments · doi:10.3791/52154 · Cited by 27 · see citing works
Fecal Microbiota Transplantation for Clostridium difficile Infection: The Ochsner Experience.
Ray, A., Smith, R., & Breaux, J. (2014) · PubMed Central · Cited by 24 · see citing works
Quraishi, M. N., Segal, J. P., Mullish, B. H., McCune, V. L., Hawkey, P. M., Colville, A., Williams, H. R. T., Hart, A. L., & Iqbal, T. H. (2016) · Journal of Hospital Infection · doi:10.1016/j.jhin.2016.10.023 · Cited by 24 · see citing works
Fecal microbiota transplant for Clostridium difficile infection in older adults
Tauxe, W. M., Haydek, J. P., Rebolledo, P. A., Neish, E., Newman, K. L., Ward, A., Dhere, T., & Kraft, C. S. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15622600 · Cited by 16 · see citing works
Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile
Ganc, A. J., Ganc, R. L., Reimão, S. M., Frisoli, A., & Pasternak, J. (2015) · Einstein (São Paulo) · doi:10.1590/s1679-45082015md3106 · Cited by 13 · see citing works
Experience with fecal microbiota transplantation in the treatment ofClostridium difficileinfection
Vigvári, S., Nemes, Z., Vincze, Á., Solt, J., Sipos, D., Feiszt, Z., Kappéter, Á., Kovács, B., & Péterfi, Z. (2014) · Orvosi Hetilap · doi:10.1556/oh.2014.30020 · Cited by 13 · see citing works
Allegretti, J. R., Fischer, M., Papa, E., Elliott, R. J., Klank, J., Mendolia, G. M., Vo, E. T., Kassam, Z., & Smith, M. B. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31855-8 · Cited by 13 · see citing works
Drekonja, D. M., Reich, J., Gezahegn, S., Greer, N. L., Shaukat, A., MacDonald, R. H., Rutks, I., & Wilt, T. J. (2014) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Allegretti, J. R., Storm, M., Smith, M. B., Kelly, C. R., Kearney, S. M., Perrotta, A. R., Elliott, R. J., Swanson, P. K., Kassam, Z., & Alm, E. J. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31856-x · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gut microbiota in the pathogenesis of inflammatory bowel disease
Nishida, A., Inoüe, R., Inatomi, O., Bamba, S., Naito, Y., & Andoh, A. (2017) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-017-0813-5 · Cited by 1,389 · see citing works
ACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893 · see citing works
Treatment of Inflammatory Bowel Disease: A Comprehensive Review
Cai, Z., Wang, S., & Li, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.765474 · Cited by 697 · see citing works
ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections
Kelly, C. R., Fischer, M., Allegretti, J. R., LaPlante, K. L., Stewart, D. B., Limketkai, B. N., & Stollman, N. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001278 · Cited by 615 · see citing works
The Intestinal Microbiota and Colorectal Cancer
Cheng, Y., Ling, Z., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615056 · Cited by 587 · see citing works
Cammarota, G., Ianiro, G., Kelly, C. R., Mullish, B. H., Allegretti, J. R., Kassam, Z., Putignani, L., Fischer, M., Keller, J. J., Costello, S. P., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319548 · Cited by 506 · see citing works
The Super-Donor Phenomenon in Fecal Microbiota Transplantation
Wilson, B. C., Vatanen, T., Cutfield, W. S., & O'Sullivan, J. M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00002 · Cited by 420 · see citing works
Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer
Wang, N., & Fang, J. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.08.010 · Cited by 395 · see citing works
The impact of the gut microbiome on extra-intestinal autoimmune diseases
Miyauchi, E., Shimokawa, C., Steimle, A., Desai, M. S., & Ohno, H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00727-y · Cited by 375 · see citing works
Fecal microbiota transplantation: current challenges and future landscapes
Yadegar, A., Bar‐Yoseph, H., Monaghan, T. M., Pakpour, S., Severino, A., Kuijper, E. J., Smits, W. K., Terveer, E. M., Neupane, S., Nabavi-Rad, A., et al. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-22 · Cited by 379 · see citing works
Rebuilding the Gut Microbiota Ecosystem
Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081679 · Cited by 340 · see citing works
Halkjær, S. I., Christensen, A. H., Lo, B. Z. S., Browne, P. D., Günther, S., Hansen, L. H., & Petersen, A. M. (2018) · Gut · doi:10.1136/gutjnl-2018-316434 · Cited by 340 · see citing works
Clinical Application and Potential of Fecal Microbiota Transplantation
Ooijevaar, R. E., Terveer, E. M., Verspaget, H. W., Kuijper, E. J., & Keller, J. J. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-111717-122956 · Cited by 337 · see citing works
Mullish, B. H., Quraishi, M. N., Segal, J. P., McCune, V. L., Baxter, M., Marsden, G. L., Moore, D., Colville, A., Bhala, N. B., Iqbal, T. H., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-316818 · Cited by 338 · see citing works
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331 · see citing works
The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications.
Allegretti, J. R., Mullish, B. H., Kelly, C., & Fischer, M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31266-8 · Cited by 358 · see citing works
Baunwall, S. M. D., Lee, M. M., Eriksen, M. K., Mullish, B. H., Marchesi, J. R., Dahlerup, J. F., & Hvas, C. L. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100642 · Cited by 302 · see citing works
Harnessing the microbiome to prevent global biodiversity loss
Peixoto, R. S., Voolstra, C. R., Sweet, M. J., Duarte, C. M., Carvalho, S., Villela, H., Lunshof, J. E., Gram, L., Woodhams, D. C., Walter, J., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01173-1 · Cited by 274 · see citing works
Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders
Metwaly, A., Reitmeier, S., & Haller, D. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00581-2 · Cited by 263 · see citing works
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation
Amoroso, C., Perillo, F., Strati, F., Fantini, M. C., Caprioli, F., & Facciotti, F. (2020) · Cells · doi:10.3390/cells9051234 · Cited by 243 · see citing works
Fecal Microbiota Transplantation: An Update on Clinical Practice
Kim, K. O., & Glück, M. (2019) · Clinical Endoscopy · doi:10.5946/ce.2019.009 · Cited by 240 · see citing works
Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review
Zhang, Z., Mocanu, V., Cai, C., Dang, J. T., Slater, L., Deehan, E. C., Walter, J., & Madsen, K. L. (2019) · Nutrients · doi:10.3390/nu11102291 · Cited by 235 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention
Song, J. H., & Kim, Y. S. (2018) · Gut and Liver · doi:10.5009/gnl18071 · Cited by 223 · see citing works
Kelly, C. R., Yen, E. F., Grinspan, A. M., Kahn, S. A., Atreja, A., Lewis, J. D., Moore, T. A., Rubin, D. T., Kim, A. M., Serra, S. M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.038 · Cited by 215 · see citing works
Fecal microbiota transplantation in disease therapy
Antushevich, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.12.010 · Cited by 215 · see citing works
Ianiro, G., Maida, M., Burisch, J., Simonelli, C., Hold, G., Ventimiglia, M., Gasbarrini, A., & Cammarota, G. (2018) · United European Gastroenterology Journal · doi:10.1177/2050640618780762 · Cited by 203 · see citing works
Kump, P., Wurm, P., Gröchenig, H. P., Wenzl, H., Petritsch, W., Halwachs, B., Wagner, M., Stadlbauer, V., Eherer, A., Hoffmann, K. M., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14387 · Cited by 196 · see citing works
Leonardi, I., Paramsothy, S., Doron, I., Semon, A., Kaakoush, N. O., Clemente, J. C., Faith, J. J., Borody, T. J., Mitchell, H. M., Colombel, J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.006 · Cited by 174 · see citing works
Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection
Wang, C., Li, Q., & Ren, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01873 · Cited by 167 · see citing works
Gut integrity in critical illness
Otani, S., & Coopersmith, C. M. (2019) · Journal of Intensive Care · doi:10.1186/s40560-019-0372-6 · Cited by 165 · see citing works
Sartelli, M., Di Bella, S., McFarland, L. V., Khanna, S., Furuya-Kanamori, L., Abuzeid, N., Abu-Zidan, F. M., Ansaloni, L., Augustin, G., Bala, M., et al. (2019) · World Journal of Emergency Surgery · doi:10.1186/s13017-019-0228-3 · Cited by 159 · see citing works
Fecal microbiota transplantation beyond Clostridioides difficile infections
Wortelboer, K., Nieuwdorp, M., & Herrema, H. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.05.066 · Cited by 163 · see citing works
Ianiro, G., Masucci, L., Quaranta, G., Simonelli, C., Lopetuso, L. R., Sanguinetti, M., Gasbarrini, A., & Cammarota, G. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14816 · Cited by 152 · see citing works
Microbiome therapeutics: exploring the present scenario and challenges
Yadav, M., & Chauhan, N. S. (2021) · Gastroenterology report · doi:10.1093/gastro/goab046 · Cited by 157 · see citing works
New Insights and Potential Therapeutic Interventions in Metabolic Diseases
Clemente‐Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., López-Mora, C., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310672 · Cited by 166 · see citing works
Update of treatment algorithms for Clostridium difficile infection
Ooijevaar, R. E., van Beurden, Y. H., Terveer, E. M., Goorhuis, A., Bauer, M. P., Keller, J. J., Mulder, C. J. J., & Kuijper, E. J. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.12.022 · Cited by 142 · see citing works
Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?
Aron‐Wisnewsky, J., Clément, K., & Nieuwdorp, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1180-z · Cited by 144 · see citing works
Hui, W., Li, T., Liu, W., Zhou, C., & Gao, F. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210016 · Cited by 140 · see citing works
RetractedGut microbiota: novel therapeutic target for nonalcoholic fatty liver disease
Suk, K. T., & Kim, D. J. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1569513 · Cited by 133 · see citing works
Pathogenicity and virulence of Clostridioides difficile
Buddle, J. E., & Fagan, R. P. (2022) · Virulence · doi:10.1080/21505594.2022.2150452 · Cited by 133 · see citing works
Dailey, F. E., Turse, E. P., Daglilar, E. S., & Tahan, V. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.04.008 · Cited by 131 · see citing works
Lopetuso, L. R., Deleu, S., Godny, L., Petito, V., Puca, P., Facciotti, F., Sokol, H., Ianiro, G., Masucci, L., Abreu, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329948 · Cited by 129 · see citing works
Lahtinen, P., Jalanka, J., Hartikainen, A. K., Mattila, E. J., Hillilä, M. T., Punkkinen, J., Koskenpato, J., Anttila, V., Tillonen, J., Satokari, R. M., et al. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15740 · Cited by 130 · see citing works
Jiang, Z., Jenq, R. R., Ajami, N. J., Petrosino, J. F., Alexander, A., Ke, S., Iqbal, T., Dupont, A. W., Muldrew, K. L., Shi, Y., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205064 · Cited by 127 · see citing works
Bicknell, B. T., Liebert, A. D., Borody, T. J., Herkes, G., McLachlan, C. S., & Kiat, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119577 · Cited by 129 · see citing works
Saha, S., Tariq, R., Tosh, P. K., Pardi, D. S., & Khanna, S. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.04.006 · Cited by 124 · see citing works
Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children
Nicholson, M. R., Mitchell, P. D., Alexander, E., Ballal, S. A., Bartlett, M., Becker, P., Davidovics, Z. H., Docktor, M., Dole, M., Felix, G., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.04.037 · Cited by 124 · see citing works
Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
Bibbò, S., Settanni, C. R., Porcari, S., Bocchino, E., Ianiro, G., Cammarota, G., & Gasbarrini, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061757 · Cited by 127 · see citing works
Li, N., Zuo, B., Huang, S., Zeng, B., Han, D., Li, T., Liu, T., Wu, Z., Wei, H., Zhao, J., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00917-7 · Cited by 120 · see citing works
Lai, C. Y., Sung, J. C. Y., Cheng, F., Tang, W., Wong, S. H., Chan, P. K. S., Kamm, M. A., Sung, J. J. �., Kaplan, G. G., Chan, F. K. L., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15116 · Cited by 119 · see citing works
Holster, S., Lindqvist, C. M., Repsilber, D., Salonen, A., de Vos, W. M., König, J., & Brummer, R. J. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000034 · Cited by 118 · see citing works
New Approaches to Microbiome-Based Therapies
Wong, A. C., & Levy, M. (2019) · mSystems · doi:10.1128/msystems.00122-19 · Cited by 112 · see citing works
Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease: An Update
Tan, P., Li, X., Shen, J., & Feng, Q. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.574533 · Cited by 111 · see citing works
Delivery routes for faecal microbiota transplants: Available, anticipated and aspired
Gulati, M., Singh, S. K., Corrie, L., Kaur, I. P., & Chandwani, L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104954 · Cited by 112 · see citing works
Haifer, C., Kelly, C. R., Paramsothy, S., Andresen, D. N., Papanicolas, L. E., McKew, G. L., Borody, T. J., Kamm, M. A., Costello, S. P., Andrews, J. M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320260 · Cited by 106 · see citing works
Baktash, A., Terveer, E. M., Zwittink, R. D., Hornung, B., Corver, J., Kuijper, E. J., & Smits, W. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01242 · Cited by 102 · see citing works
Ramai, D., Zakhia, K., Fields, P. J., Ofosu, A., Patel, G., Shahnazarian, V., Lai, J., Dhaliwal, A., Reddy, M., & Chang, S. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06185-7 · Cited by 103 · see citing works
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101 · see citing works
Moreira-Rosário, A., Marques, C., Pinheiro, H., Araújo, J. R., Ribeiro, P., Rocha, R., Barreiros-Mota, I., Pestana, D., Ribeiro, R., Pereira, A. M., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.705020 · Cited by 100 · see citing works
Shiga Toxin–Producing <i>Escherichia coli</i> Transmission via Fecal Microbiota Transplant
Zellmer, C., Sater, M. R. A., Huntley, M. H., Osman, M., Olesen, S. W., & Ramakrishna, B. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1486 · Cited by 98 · see citing works
Ramai, D. (2018) · Annals of Gastroenterology · doi:10.20524/aog.2018.0328 · Cited by 98 · see citing works
Minkoff, N. Z., Aslam, S., Medina, M., Tanner‐Smith, E. E., Zackular, J. P., Acra, S. A., Nicholson, M. R., & Imdad, A. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013871.pub2 · Cited by 99 · see citing works
The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome
Yu, Y., Wang, W., & Zhang, F. (2023) · Advanced Science · doi:10.1002/advs.202301097 · Cited by 94 · see citing works
Xiang, Q., Wu, X., Pan, Y., Wang, L., Cui, C., Guo, Y., Zhu, L., Peng, J., & Wei, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020503 · Cited by 90 · see citing works
Akobeng, A. K., Singh, P., Kumar, M., & Khodor, S. A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02324-y · Cited by 92 · see citing works
Yadegar, A., Pakpour, S., Ibrahim, F. F., Nabavi-Rad, A., Cook, L. E., Walter, J., Seekatz, A. M., Wong, K., Monaghan, T. M., & Kao, D. H. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.019 · Cited by 86 · see citing works
Cerquetella, M., Rossi, G., Suchodolski, J. S., Schmitz, S. S., Allenspach, K., Rodríguez‐Franco, F., Furlanello, T., Gavazza, A., Marchegiani, A., Unterer, S., et al. (2020) · Journal of Small Animal Practice · doi:10.1111/jsap.13122 · Cited by 85 · see citing works
Chen, X., Li, H., Hu, X., Zhang, Y., & Zhang, S. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000330 · Cited by 84 · see citing works
Kalinkovich, A., & Livshits, G. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.05.007 · Cited by 85 · see citing works
Wardill, H. R., Secombe, K. R., Bryant, R. V., Hazenberg, M. D., & Costello, S. P. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.070 · Cited by 83 · see citing works
Therapies to modulate gut microbiota: Past, present and future
Gupta, A., Saha, S., & Khanna, S. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i8.777 · Cited by 83 · see citing works
Gut microbiome and autoimmune disorders
Shaheen, W., Quraishi, M. N., & Iqbal, T. H. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac057 · Cited by 85 · see citing works
Mullish, B. H., Quraishi, M. N., Segal, J. P., McCune, V. L., Baxter, M., Marsden, G. L., Moore, D., Colville, A., Bhala, N. B., Iqbal, T. H., et al. (2018) · Journal of Hospital Infection · doi:10.1016/j.jhin.2018.07.037 · Cited by 78 · see citing works
The role of the microbiota in the management of intensive care patients
Szychowiak, P., Villageois-Tran, K., Patrier, J., Timsit, J., & Ruppé, É. (2022) · Annals of Intensive Care · doi:10.1186/s13613-021-00976-5 · Cited by 81 · see citing works
Cruz-Aguliar, R. M., Wantia, N., Clavel, T., Vehreschild, M. J. G. T., Buch, T., Bajbouj, M., Haller, D., Busch, D. H., Schmid, R. M., & Stein‐Thoeringer, C. K. (2018) · Digestion · doi:10.1159/000494252 · Cited by 77 · see citing works
Seekatz, A. M., Safdar, N., & Khanna, S. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221134396 · Cited by 79 · see citing works
The role of the microbiome in gastrointestinal inflammation
Sanders, D. J., Inniss, S., Sebepos‐Rogers, G., Rahman, F. Z., & Smith, A. M. (2021) · Bioscience Reports · doi:10.1042/bsr20203850 · Cited by 78 · see citing works
Microbiota therapeutics for inflammatory bowel disease: the way forward
Bethlehem, L., Estevinho, M. M., Grinspan, A. M., Magro, F., Faith, J. J., & Colombel, J. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00441-7 · Cited by 80 · see citing works
The role of gut microbiota in Clostridium difficile infection
Samarkos, M., Mastrogianni, E., & Kampouropoulou, O. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.02.006 · Cited by 75 · see citing works
Alessandri, G., Argentini, C., Milani, C., Turroni, F., Ossiprandi, M. C., van Sinderen, D., & Ventura, M. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13656 · Cited by 61 · see citing works
From taxonomy to metabolic output: what factors define gut microbiome health?
Wilmanski, T., Rappaport, N., Diener, C., Gibbons, S. M., & Price, N. D. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907270 · Cited by 73 · see citing works
Podlesny, D., Arze, C., Dörner, E., Verma, S., Dutta, S., Walter, J., & Fricke, W. F. (2022) · Microbiome · doi:10.1186/s40168-022-01251-w · Cited by 73 · see citing works
Borody, T. J., Eslick, G. D., & Clancy, R. L. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.04.017 · Cited by 72 · see citing works
A Review of Clostridioides difficile Infection and Antibiotic-Associated Diarrhea
Abad, C. L. R., & Safdar, N. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.010 · Cited by 72 · see citing works
The central role of the gut in intensive care
Corriero, A., Gadaleta, R. M., Puntillo, F., Inchingolo, F., Moschetta, A., & Brienza, N. (2022) · Critical Care · doi:10.1186/s13054-022-04259-8 · Cited by 75 · see citing works
Bar‐Yoseph, H., Carasso, S., Shklar, S., Korytny, A., Dar, R. E., Daoud, H., Nassar, R., Maharshak, N., Hussein, K., Geffen, Y., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa737 · Cited by 70 · see citing works
The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health
Bui, T. V. A., Hwangbo, H., Lai, Y., Hong, S. B., Choi, Y.-J., Park, H., & Ban, K. (2023) · Korean Circulation Journal · doi:10.4070/kcj.2023.0048 · Cited by 70 · see citing works
Microbe-based therapies for colorectal cancer: Advantages and limitations
Saeed, M., Shoaib, A., Kandimalla, R., Javed, S., Almatroudi, A., Gupta, R. C., & Aqil, F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.018 · Cited by 69 · see citing works
A review of gut failure as a cause and consequence of critical illness
Soranno, D. E., Coopersmith, C. M., Brinkworth, J. F., Factora, F. N., Muntean, J. H., Mythen, M. G., Raphael, J., Shaw, A., Vachharajani, V., & Messer, J. S. (2025) · Critical Care · doi:10.1186/s13054-025-05309-7 · Cited by 74 · see citing works
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease
Basson, A. R., Zhou, Y., Seo, B., Rodriguez‐Palacios, A., & Cominelli, F. (2020) · Translational research · doi:10.1016/j.trsl.2020.05.008 · Cited by 71 · see citing works
Rokkas, T., Gisbert, J. P., Gasbarrini, A., Hold, G. L., Tilg, H., Malfertheiner, P., Mégraud, F., & O'Morain, C. A. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619854587 · Cited by 68 · see citing works
Terveer, E. M., Vendrik, K. E. W., Ooijevaar, R. E., van Lingen, E., Boeije‐Koppenol, E., van Nood, E., Goorhuis, A., Bauer, M. P., van Beurden, Y. H., Dijkgraaf, M. G. W., et al. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620957765 · Cited by 64 · see citing works
Jalanka, J., Hillamaa, A., Satokari, R. M., Mattila, E., Anttila, V., & Arkkila, P. E. T. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14443 · Cited by 64 · see citing works
Wu, J., Lv, L., & Wang, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.827395 · Cited by 63 · see citing works
Zikou, E., Koliaki, C. C., & Makrilakis, K. (2024) · Biomedicines · doi:10.3390/biomedicines12081871 · Cited by 67 · see citing works
Kwak, S., Choi, J., Hink, T., Reske, K. A., Blount, K., Jones, C. R., Bost, M. H., Sun, X., Burnham, C. D., Dubberke, E. R., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00907-9 · Cited by 62 · see citing works
Khan, M. Y., Dirweesh, A. M., Khurshid, T., & Siddiqui, W. J. (2018) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001243 · Cited by 62 · see citing works
Quraishi, M. N., Shaheen, W., Oo, Y. H., & Iqbal, T. H. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13397 · Cited by 62 · see citing works
Potential in vivo delivery routes of postbiotics
Abbasi, A., Hajipour, N., Hasannezhad, P., Baghbanzadeh, A., & Maleki, L. A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1865260 · Cited by 61 · see citing works
- Authors
- Quraishi, M. N., Widlak, M., Bhala, N., Moore, D., Price, M., Sharma, N., & Iqbal, T. H.
- Affiliations
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University Hospital Coventry (GB)
- University of Birmingham (GB)
- Corresponding author
- Iqbal, T. H.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2017-07-14
- Volume
- 46
- Issue
- 5
- Pages
- 479-493
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2735259022
- Cited by
- 617
- References
- 70
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 68 · 2023: 75 · 2022: 87 · 2021: 81 · 2020: 95 · 2019: 73 · 2018: 38 · 2017: 6
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research (13/179/01, EME/13/179/01)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, Clostridium difficile infection, recurrent Clostridium difficile infection, vancomycin, mode of delivery, donor screening, recipient preparation, nosocomial diarrhea, adverse events
- MeSH terms
- Fecal Microbiota Transplantation, Clostridium Infections, Cross Infection, Diarrhea, Humans, Vancomycin, Randomized Controlled Trials as Topic, Clostridioides difficile, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review