Cited by 1,033Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceEnterobacteriaceae and Cronobacter Research

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Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

Gupta, N., Limbago, B. M., Patel, J. B., Kallen, A. J.·2011·Clinical Infectious Diseases

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Abstract

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

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Authors: Gupta, N., Limbago, B. M., Patel, J. B., & Kallen, A. J.
Affiliations: Centers for Disease Control and Prevention (US)
ORCID: Gupta, N.
Patel, J. B.
Kallen, A. J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2011-06-07
Volume: 53
Issue: 1
Pages: 60-67
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/cir202
OpenAlex: W2113898837
Cited by: 1,033
References: 48
Citations by year: 2026: 20 · 2025: 32 · 2024: 36 · 2023: 54 · 2022: 60 · 2021: 68 · 2020: 78 · 2019: 96 · 2018: 80 · 2017: 99 · 2016: 82 · 2015: 92 · 2014: 97 · 2013: 77 · 2012: 54
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: Kimberly-Clark
Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
Keywords: carbapenem-resistant Enterobacteriaceae, KPC, New Delhi metallo-beta-lactamase, mobile genetic elements, infection control, antimicrobial resistance, United States
MeSH terms: Bacterial Proteins, beta-Lactamases, Enterobacteriaceae, Enterobacteriaceae Infections, Humans, Carbapenems, Drug Resistance, Bacterial

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Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

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