Burden of Malaria in Early Pregnancy: A Neglected Problem?

Huynh, B.-T.; Cottrell, G.; Cot, M.; Briand, V.

doi:10.1093/cid/ciu848

Cited by 63Malaria Research and ControlTravel-related health issuesHemoglobinopathies and Related Disorders

Burden of Malaria in Early Pregnancy: A Neglected Problem?

Huynh, B.-T., Cottrell, G., Cot, M., Briand, V.·2015·Clinical Infectious Diseases

DOI 10.1093/cid/ciu848

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Abstract

Drugs to prevent malaria in pregnancy are not recommended during the first trimester in high-transmission areas. Poor outcomes associated with infections in early pregnancy emphasize that operational and research challenges of malaria during this period need to be addressed. According to the current World Health Organization guidelines, the drug prevention of malaria during pregnancy does not adequately cover the first trimester of gestation in high-transmission areas. Although the pathophysiological mechanisms of early infections are not completely understood yet, a review of the most recent studies on the topic suggests that their consequences are serious in terms of maternal anemia and low birth weight. Consequently, there is a need to focus on the awareness of women in a period hard to access, to develop safe drugs to be used in the first trimester, and to consider preconceptional interventions in teenage girls, such as a new malaria vaccine to be used in pregnancy.

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Falciparum infection and disease in pregnancy are commonly manifested as maternal anaemia, pre-term delivery and low birth weight, and are linked to poor infant development and increased neonatal and infant morbidity and mortality, especially in low transmission settings.
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Authors: Huynh, B.-T., Cottrell, G., Cot, M., & Briand, V.
Affiliations: Sorbonne Paris Cité (FR)
Corresponding author: Huynh, B.-T.
ORCID: Huynh, B.-T.
Cottrell, G.
Cot, M.
Briand, V.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2014-10-30
Volume: 60
Issue: 4
Pages: 598-604
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/ciu848
OpenAlex: W2160672611
Cited by: 63
References: 42
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 2
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords: malaria in pregnancy, first trimester, malaria prophylaxis, anemia in pregnancy, low birth weight, WHO guidelines, adolescent girls
MeSH terms: Adolescent, Anemia, Antimalarials, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Malaria, Pregnancy, Pregnancy Trimester, First, Pregnancy Complications, Parasitic, Cost of Illness, Malaria Vaccines

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Burden of Malaria in Early Pregnancy: A Neglected Problem?

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