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A simple method for clinical assay of superoxide dismutase.
Abstract
This assay for superoxide dismutase (SOD, EC 1.15.1.1) activity involves inhibition of nitroblue tetrazolium reduction, with xanthine-xanthine oxidase used as a superoxide generator. By using a reaction terminator, we can determine 40 samples within 55 min. One unit of activity of pure bovine liver Cu,ZnSOD and chicken liver MnSOD was expressed by 30 ng and 500 ng of protein, respectively. The mean concentrations of Cu,ZnSOD as measured by this method in blood from normal adults were 242 (SEM 4) mg/L in erythrocytes, 548 (SEM 20) micrograms/L in serum, and 173 (SEM 11) micrograms/L in plasma. The Cu,ZnSOD concentrations in serum and plasma of patients with cancer of the large intestine tended to be less and greater than these values, respectively, but not statistically significantly so.
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Cited by
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Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368
Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322
Akyol, Ö., Herken, H., Uz, E., Fadıllıoǧlu, E., Ünal, S., Söǧüt, S., Özyurt, H., & Savaş, H. A. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00220-8 · Cited by 278
Metadata
- Authors
- Sun, Y., Oberley, L. W., & Li, Y.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-03-01
- Volume
- 34
- Issue
- 3
- Pages
- 497-500
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2159305277
- Cited by
- 4,504
- References
- 0
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, Y., Oberley, L. W., & Li, Y. (1988). A simple method for clinical assay of superoxide dismutase. Clinical Chemistry. https://doi.org/10.1093/clinchem/34.3.497
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
