The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Blood glutathione concentrations in a large-scale human study
Abstract
Little is known about the variability of blood glutathione (GSH) in human subjects. Thus, we wanted to develop and validate a rapid method for measuring GSH concentrations in whole blood and apply this method to ascertain the variation of GSH in a large-scale study of free-living adults. The assay was highly sensitive (detection limit < 5 pmol) and precise, with an interassay variation of 2.3% and a sampling variation of 3.6%. Applying this method to screen 715 adults, we observed a threefold range of GSH concentrations, with a mean of 1.02 mmol/L and CV of 17%. GSH concentrations were 8-10% greater in smokers than in nonsmokers (P < 0.001). Although we observed no sex differences for GSH, GSH/hemoglobin ratios were 8-18% greater in women < 55 years old than in older subjects (P < 0.05). The results presented here validate the use of this method for large-scale human studies and provide information on the variation and normal values of blood GSH in adults.
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Citations
Cites
Glutathione Deficiency and Human Immunodeficiency Virus Infection
Staal, F. J. T., Ela, S. W., Roederer, M., Anderson, M. T., Herzenberg, L. A., & Herzenberg, L. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)90939-z · Cited by 404
Cited by
ZITKA, O., SKALICKOVA, S., GUMULEC, J., MASARIK, M., ADAM, V., HUBALEK, J., TRNKOVA, L., KRUSEOVA, J., ECKSCHLAGER, T., & KIZEK, R. (2012) · Oncology Letters · doi:10.3892/ol.2012.931 · Cited by 664
The potential of nitric oxide releasing therapies as antimicrobial agents
Schairer, D. O., Chouake, J. S., Nosanchuk, J. D., & Friedman, A. J. (2012) · Virulence · doi:10.4161/viru.20328 · Cited by 573
Status of glutathione and other thiols and disulfides in human plasma
Kleinman, W. A., & Richie, J. P. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00293-8 · Cited by 349
Self-citationChemical Transformations of Nanosilver in Biological Environments
Liu, J., Wang, Z., Liu, F. D., Kane, A. B., & Hurt, R. H. (2012) · ACS Nano · doi:10.1021/nn303449n · Cited by 314
The effect of smoking on chronic inflammation, immune function and blood cell composition
Elisia, I., Lam, V., Cho, B., Hay, M., Li, M. Y., Yeung, M., Bu, L., Jia, W., Norton, N., Lam, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76556-7 · Cited by 263
Metadata
- Authors
- Richie, J. P., Skowronski, L., Abraham, P., & Leutzinger, Y.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-01-01
- Volume
- 42
- Issue
- 1
- Pages
- 64-70
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2164760296
- Cited by
- 233
- References
- 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Richie, J. P., Skowronski, L., Abraham, P., & Leutzinger, Y. (1996). Blood glutathione concentrations in a large-scale human study. Clinical Chemistry. https://doi.org/10.1093/clinchem/42.1.64
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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