The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Accurate measurement of cholecystokinin in plasma
Abstract
Shortage of reliable plasma assays has hampered studies of cholecystokinin (CCK). The assay problems are low plasma concentrations, extensive molecular heterogeneity, and close homology of CCK to gastrin, which circulates in higher concentrations. To develop an accurate CCK RIA, antibodies were raised in rabbits, guinea pigs, and mice in titers from 200 to 4 000 000. The specificity of the antisera was tested with homologous peptides, and tissue and plasma extracts. Rabbit 92128 produced antibodies in high titer (≥500 000) with sufficient avidity (K \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(_{eff}^{{^\circ}}\) \end{document} ≥ 1012 mol−1) and the desired specificity. The antiserum binds the bioactive forms of CCK with equimolar potency and displays no reactivity with gastrin. CCK concentrations in plasma from healthy humans rose from 1.13 ± 0.10 pmol/L (mean ± SE, n = 26) to 4.92 ± 0.34 pmol/L after a mixed meal. Chromatography of human plasma revealed traces of CCK-58, a predominance of CCK-33 and CCK-22, and moderate amounts of CCK-8. The results show that it is possible to produce specific CCK-antisera using a sulfated CCK-12 analog.
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Evidence for coexistence of dopamine and CCK in meso-limbic neurones
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Self-citationLarsson, L.-I., & Rehfeld, J. F. (1979) · Brain Research · doi:10.1016/0006-8993(79)90554-7 · Cited by 663
Self-citationLocalization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons.
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Self-citationBioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol
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Cited by
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, D., Almdal, T., Naver, L. S., Hvolris, L. E., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0621-4 · Cited by 342
Self-citationGhrelin stimulates gastric emptying and hunger in normal-weight humans
Levin, F., Edholm, T., Schmidt, P. T., Grybäck, P., Jacobsson, H., Degerblad, M., Höybye, C., Holst, J. J., Rehfeld, J. F., Hellström, P. M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2638 · Cited by 313
Self-citationCholecystokinin—From Local Gut Hormone to Ubiquitous Messenger
Rehfeld, J. F. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00047 · Cited by 265
Self-citationSvane, M. S., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Nielsen, S., Kristiansen, V. B., Toräng, S., Wewer Albrechtsen, N. J., Rehfeld, J. F., Hartmann, B., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.121 · Cited by 185
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Metadata
- Authors
- Rehfeld, J. F.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05-01
- Volume
- 44
- Issue
- 5
- Pages
- 991-1001
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2156711661
- Cited by
- 320
- References
- 42
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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