The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Vaginitis due to Saccharomyces cerevisiae: epidemiology, clinical aspects and therapy
Abstract
Vaginitis due to Saccharomyces species is extremely rare. Nine patients with 20 vaginal isolates of Saccharomyces cerevisiae who presented with either asymptomatic vaginal colonization or symptomatic vaginitis indistinguishable from that caused by Candida albicans are described. All patients had a history of chronic or recurrent vaginitis, and all but two had systemic or local predisposing factors. In vitro tests of antimycotic sensitivity revealed reduced susceptibility of S. cerevisiae to the majority of available azole agents, with outright resistance to fluconazole. In accordance with these findings, the clinical response to conventional topical and oral antimycotic drugs was frequently suboptimal and incomplete. Electrophoretic karyotyping of strains revealed several distinct types of S. cerevisiae; this information permitted both longitudinal follow-up and differentiation of relapse from reinfection. In three patients with recurrent vaginitis, a unique epidemiological relationship was documented between S. cerevisiae and Torulopsis glabrata, another unusual and resistant vaginal pathogen. Isolation of S. cerevisiae from the vagina of symptomatic patients should not be ignored; treatment of vaginal infection with this yeast requires selected, often prolonged therapy.
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“the resistance of S. cerevisiae to certain antifungal agents has been also repeatedly observed.2,26,36,38”
Citations
Cites
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Vázquez, J. A., Beckley, A., Sobel, J. D., & Zervos, M. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.5.962-967.1991 · Cited by 92
Self-citationTorulopsis glabrata vaginitis: Clinical aspects and susceptibility to antifungal agents
REDONDO-LOPEZ, V., Lynch, M., Schmitt, C., Cook, R. L., & Sobel, J. D. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90322-v · Cited by 83
Self-citationStenderup, A., & Pedersen, G. T. (1962) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1962.tb05088.x · Cited by 70
Evaluation of industrial yeasts for pathogenicity
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Candida tropicalis vulvovaginitis.
Horowitz, B. J., EDELSTEIN, S. W., & LIPPMAN, L. (1985) · PubMed · Cited by 51
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[Isolation of teleomorphs from clinical specimens.].
Hernández-Molina, J. M., & García-Martos, P. (1998) · PubMed · Cited by 3
Recurrent vulvovaginal candidiasis associated with the use of a probiotic supplement
Neal, C. M., Gonzalez, A., Oshinowo, A. E., Fazle, T., & Kako, T. D. (2025) · IDCases · doi:10.1016/j.idcr.2025.e02285 · Cited by 2
“…study looking at the prevalence and susceptibility of S. cerevisiae , it was found that in the 6 % of women with S. cerevisiae vaginitis, all of the isolates identified were resistant to fluconazole, posaconazole, and itraconazole, and were only sensitive to voriconazole and caspofungin [2,13].”
Herbal Suppositorries as Saviour of Mankind; An Advanced Review
Rai, C., Tiwari, S., Dhaker, K. S., & Singhai, A. K. (2024) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2024.00057 · Cited by 1
Vulvovaginitis por Candida en diabéticas y embarazadas
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Zupan, J., Tomičić, Z., & Raspor, P. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2324-y · Cited by 1
“What is known is that (i) low susceptibility to azole antimycotics is regularly observed [19–21], (ii) many strains are tolerant to high temperatures, such as 42 °C [17, 22], and some strains of S.”
BackgroundInfection Due to Non-Candidal Yeasts
Vázquez, J. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-13090-3_9 · Cited by 1
Mingo, A., Stone, D., Schreiner, A. D., & Lueking, R. R. (2025) · Journal of Investigative Medicine High Impact Case Reports · doi:10.1177/23247096251322284 · Cited by 1
“11 While her urinalysis showed elevated squamous epithelial cells (15/ HPF), it is possible that the lack of WBC could be attributed to her preceding immunosuppressive therapy.”
Evolutionary Implications and Genetic Basis of Peroxide Survival in Saccharomyces cerevisiae
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Zupan, J., Matos, T., Čenčič, A., & Raspor, P. (2013) · Zbornik Matice srpske za prirodne nauke · doi:10.2298/zmspn1324379z
Silva, J. O., Franceschini, S. A., & Cândido, R. C. (2002)
Paulovičová, E., & Hrubiško, M. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152154 · Cited by 1
Infection Due to Non-Candidal Yeasts
Vazquez, J. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-325-7_8
Self-citation(2006) · Springer eBooks · doi:10.1007/978-3-540-30096-0_8
Rowen, J. L. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4044-6.50224-7
Yan, Z., Cui, Y., Li, Y., Xiao, X., Liao, M., Liu, X., Zhou, W., Kuang, L., & Jiang, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1944046
“S. cerevisiae has been recovered in both asymptomatic carriage and symptomatic vaginitis, with source-dependent susceptibility patterns (Sobel et al., 1993; Yan et al., 2024).”
Influential
Metadata
- Authors
- Sobel, J. D., Vazquez, J., Lynch, M., Meriwether, C., & Zervos, M. J.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Sobel, J. D.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-01-01
- Volume
- 16
- Issue
- 1
- Pages
- 93-99
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2109797093
- Cited by
- 117
- References
- 19
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Saccharomyces cerevisiae, vaginal candidiasis, vaginal infection, recurrent vaginitis, Candida albicans, azole resistance, fluconazole resistance, Candida glabrata, relapse versus reinfection, vaginal colonization, antifungal therapy
- MeSH terms
- Adult, Antifungal Agents, Female, Humans, Microbial Sensitivity Tests, Middle Aged, Mycoses, Recurrence, Saccharomyces cerevisiae, Vagina, Vaginitis
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