Invasive infection with Saccharomyces cerevisiae: report of three cases and review
Abstract
Saccharomyces cerevisiae (brewer's or baker's yeast) is a common colonizer of human mucosal surfaces, but its role as a clinically important pathogen has been unclear. We report three cases of life-threatening invasive infection with S. cerevisiae resulting in pneumonia, liver abscess and sepsis, and disseminated infection with cardiac tamponade, respectively. A review of the English-language literature reveals 14 other cases of saccharomyces infection in humans. Severe immunosuppression, prolonged hospitalization, prior antibiotic therapy, and/or prosthetic cardiac valves are the settings where saccharomyces infection has been observed. Because Saccharomyces can be a common saprophytic contaminant, biopsy and pathologic confirmation of infection are often necessary for a definitive diagnosis. Amphotericin B is the treatment of choice for serious infections with this organism.
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Repeated observations have shown that S. cerevisiae can resist some antifungal drugs.
“the resistance of S. cerevisiae to certain antifungal agents has been also repeatedly observed.2,26,36,38”
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Saccharomyces Cerevisiae Oesophagitis in an HIV-Infected Patient
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- Authors
- Aucott, J. N., Fayen, J., Grossnicklas, H., Morrissey, A., Lederman, M. M., & Salata, R. A.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Salata, R. A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-05-01
- Volume
- 12
- Issue
- 3
- Pages
- 406-411
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2127169490
- Cited by
- 137
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Saccharomyces cerevisiae, invasive fungal infections, liver abscess, sepsis, disseminated infection, cardiac tamponade, immunosuppression, prosthetic heart valves, amphotericin B, pathogen identification
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Mycoses, Opportunistic Infections, Saccharomyces cerevisiae
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