Cited by 138Antifungal resistance and susceptibilityFungal Infections and StudiesYeasts and Rust Fungi Studies

Invasive infection with Saccharomyces cerevisiae: report of three cases and review

Aucott, J. N., Fayen, J., Grossnicklas, H., Morrissey, A., Lederman, M. M., Salata, R. A.·1990·Clinical Infectious Diseases

Abstract

Saccharomyces cerevisiae (brewer's or baker's yeast) is a common colonizer of human mucosal surfaces, but its role as a clinically important pathogen has been unclear. We report three cases of life-threatening invasive infection with S. cerevisiae resulting in pneumonia, liver abscess and sepsis, and disseminated infection with cardiac tamponade, respectively. A review of the English-language literature reveals 14 other cases of saccharomyces infection in humans. Severe immunosuppression, prolonged hospitalization, prior antibiotic therapy, and/or prosthetic cardiac valves are the settings where saccharomyces infection has been observed. Because Saccharomyces can be a common saprophytic contaminant, biopsy and pathologic confirmation of infection are often necessary for a definitive diagnosis. Amphotericin B is the treatment of choice for serious infections with this organism.

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Crossref · 10.1093/clinids/12.3.406

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15 of 15 references verified0 citation errors · 0 not checkable

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Authors
Aucott, J. N., Fayen, J., Grossnicklas, H., Morrissey, A., Lederman, M. M., & Salata, R. A.
Affiliations
Case Western Reserve University (US)
Corresponding author
Salata, R. A.
Venue
Clinical Infectious Diseases
Published
1990-05-01
Volume
12
Issue
3
Pages
406-411
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2127169490
Cited by
137
References
15
Citations by year
2026: 2 · 2025: 2 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords
Saccharomyces cerevisiae, invasive fungal infections, liver abscess, sepsis, disseminated infection, cardiac tamponade, immunosuppression, prosthetic heart valves, amphotericin B, pathogen identification
MeSH terms
Aged, Female, Humans, Male, Middle Aged, Mycoses, Opportunistic Infections, Saccharomyces cerevisiae

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