Cited by 117Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Vaginitis due to Saccharomyces cerevisiae: epidemiology, clinical aspects and therapy

Sobel, J. D., Vazquez, J., Lynch, M., Meriwether, C., Zervos, M. J.·1993·Clinical Infectious Diseases

Open this paper in CoChat — free account

Abstract

Vaginitis due to Saccharomyces species is extremely rare. Nine patients with 20 vaginal isolates of Saccharomyces cerevisiae who presented with either asymptomatic vaginal colonization or symptomatic vaginitis indistinguishable from that caused by Candida albicans are described. All patients had a history of chronic or recurrent vaginitis, and all but two had systemic or local predisposing factors. In vitro tests of antimycotic sensitivity revealed reduced susceptibility of S. cerevisiae to the majority of available azole agents, with outright resistance to fluconazole. In accordance with these findings, the clinical response to conventional topical and oral antimycotic drugs was frequently suboptimal and incomplete. Electrophoretic karyotyping of strains revealed several distinct types of S. cerevisiae; this information permitted both longitudinal follow-up and differentiation of relapse from reinfection. In three patients with recurrent vaginitis, a unique epidemiological relationship was documented between S. cerevisiae and Torulopsis glabrata, another unusual and resistant vaginal pathogen. Isolation of S. cerevisiae from the vagina of symptomatic patients should not be ignored; treatment of vaginal infection with this yeast requires selected, often prolonged therapy.

Integrity signals

Registry

Crossref · 10.1093/clinids/16.1.93

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fungemia in a Cancer Hospital: Changing Frequency, Earlier Onset, and Results of Therapy
Horn, R., Wong, B., Kiehn, T. E., & Armstrong, D. (1985) · Clinical Infectious Diseases · doi:10.1093/clinids/7.5.646 · Cited by 479
Multicenter evaluation of four methods of yeast inoculum preparation
Pfaller, M. A., Burmeister, L. F., Bartlett, M. S., & Rinaldi, M. G. (1988) · Journal of Clinical Microbiology · doi:10.1128/jcm.26.8.1437-1441.1988 · Cited by 455
Invasive infection with Saccharomyces cerevisiae: report of three cases and review
Aucott, J. N., Fayen, J., Grossnicklas, H., Morrissey, A., Lederman, M. M., & Salata, R. A. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.3.406 · Cited by 137
The Prevalence of Yeasts in Clinical Specimens from Cancer Patients
Kiehn, T. E., Edwards, F. F., & Armstrong, D. (1980) · American Journal of Clinical Pathology · doi:10.1093/ajcp/73.4.518 · Cited by 118
Comparison of restriction enzyme analysis and pulsed-field gradient gel electrophoresis as typing systems for Candida albicans
Vázquez, J. A., Beckley, A., Sobel, J. D., & Zervos, M. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.5.962-967.1991 · Cited by 92
Self-citation
Torulopsis glabrata vaginitis: Clinical aspects and susceptibility to antifungal agents
REDONDO-LOPEZ, V., Lynch, M., Schmitt, C., Cook, R. L., & Sobel, J. D. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90322-v · Cited by 83
Self-citation
YEASTS OF HUMAN ORIGIN
Stenderup, A., & Pedersen, G. T. (1962) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1962.tb05088.x · Cited by 70
Evaluation of industrial yeasts for pathogenicity
Holzschu, D. L., Chandler, F. W., Ajello, L., & Ahearn, D. G. (1979) · Medical Mycology · doi:10.1080/00362177985380091 · Cited by 59
Saccharomyces cerevisiae septicemia.
Eschete, M. L., & West, B. C. (1980) · PubMed · Cited by 53
Candida tropicalis vulvovaginitis.
Horowitz, B. J., EDELSTEIN, S. W., & LIPPMAN, L. (1985) · PubMed · Cited by 51

Show all 19 references

Sorted by citations

Short-sequence DNA repeats in prokaryotic genomes
van Belkum, A., Scherer, S., van Alphen, L., & Verbrugh, H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.275-293.1998 · Cited by 737
New and emerging yeast pathogens
Hazen, K. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.462 · Cited by 603
“From an epidemiologic standpoint, all of the new and emerging yeasts can be found in the environment (109, 153), and many of the Candida species and Saccharomyces cerevisiae can be isolated from human mucosal sites, especially the gastrointestinal tract and vagina (109, 138).”
Background
Saccharomyces cerevisiae Fungemia: An Emerging Infectious Disease
Munoz, P., Bouza, E., Cuenca-Estrella, M., Eiros, J. M., Perez, M. J., Sanchez-Somolinos, M., Rincon, C., Hortal, J., & Pelaez, T. (2005) · Clinical Infectious Diseases · doi:10.1086/429916 · Cited by 462
“conazole have been reported [41, 52, 79, 80].”
Antifungal Susceptibilities of Candida Species Causing Vulvovaginitis and Epidemiology of Recurrent Cases
Richter, S. S., Galask, R. P., Messer, S. A., Hollis, R. J., Diekema, D. J., & Pfaller, M. A. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.5.2155-2162.2005 · Cited by 435
“Most non-albicans Candida species have higher azole MICs, and infections they cause are often difficult to treat (10, 20, 21, 26).”
Background
Invasive Saccharomyces Infection: A Comprehensive Review
Enache-Angoulvant, A., & Hennequin, C. (2005) · Clinical Infectious Diseases · doi:10.1086/497832 · Cited by 369
“4% of cases [14, 15].”
Vulvovaginal Candidiasis: A Current Understanding and Burning Questions
Willems, H. M. E., Ahmed, S. S., Liu, J., Xu, Z., & Peters, B. M. (2020) · Journal of Fungi · doi:10.3390/jof6010027 · Cited by 357
“cerevisiae has been shown to cause vaginitis-like symptoms in a limited number of women, significant clinical testing would be required to rule out any potential negative consequence of abundant vaginal yeast colonization [139].”
Background
Pathogenesis of Candida infections
Odds, F. C. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(08)81257-1 · Cited by 220
Microsatellite Typing as a New Tool for Identification of Saccharomyces cerevisiae Strains
Hennequin, C., Thierry, A., Richard, G., Lecointre, G., Nguyen, H. V., Gaillardin, C. M., & Dujon, B. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.2.551-559.2001 · Cited by 206
Guideline: Vulvovaginal Candidosis (AWMF 015/072, Level S2k)
Farr, A., Effendy, I., Frey Tirri, B., Hof, H., Mayser, P., Petricevic, L., Ruhnke, M., Schaller, M., Schaefer, A. P. A., Sustr, V., et al. (2021) · Mycoses · doi:10.1111/myc.13248 · Cited by 184
Rapid Identification of Candida Species with Species-Specific DNA Probes
Elie, C. M., Lott, T. J., Reiss, E., & Morrison, C. J. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.11.3260-3265.1998 · Cited by 159
“cerevisiae are innately fluconazole resistant (21, 24, 31), clinical treatment decisions would most likely not be negatively impacted by the inability to discriminate C.”
Background
Chronic fungal vaginitis: The value of cultures
Nyirjesy, P., Seeney, S. M., GRODY, M. H. T., Jordan, C. A., & BUCKLEY, H. R. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90347-x · Cited by 146
Vulvovaginal carriage of yeasts other than Candida albicans
Holland, J. (2003) · Sexually Transmitted Infections · doi:10.1136/sti.79.3.249 · Cited by 132
“S cerevisiae has been considered to be a rare cause of vaginitis 1 ;however,this yeast comprised 5% of our yeasts other than C albicans isolates.”
Background
Safety studies of a novel starch, pullulan: Chronic toxicity in rats and bacterial mutagenicity
Kimoto, T., Shibuya, T., & Shiobara, S. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(97)00001-x · Cited by 122
Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (Excluding Chronic Mucocutaneous Candidosis)
Mendling, W. (2015) · Mycoses · doi:10.1111/myc.12292 · Cited by 117
Saccharomyces cerevisiae virulence phenotype as determined with CD-1 mice is associated with the ability to grow at 42 degrees C and form pseudohyphae
McCusker, J. H., Clemons, K. V., Stevens, D. A., & Davis, R. W. (1994) · Infection and Immunity · doi:10.1128/iai.62.12.5447-5455.1994 · Cited by 116
Guideline vulvovaginal candidosis (2010) of the german society for gynecology and obstetrics, the working group for infections and infectimmunology in gynecology and obstetrics, the german society of dermatology, the board of german dermatologists and the german speaking mycological society
Mendling, W., & Brasch, J. (2012) · Mycoses · doi:10.1111/j.1439-0507.2012.02185.x · Cited by 110
Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii
Cesaro, S., Chinello, P., Rossi, L., & Zanesco, L. (2000) · Supportive Care in Cancer · doi:10.1007/s005200000123 · Cited by 107
Invasive yeast infections other than Candida spp. in acute leukaemia
Kremery, V., Krupova, I., & Denning, D. W. (1999) · Journal of Hospital Infection · doi:10.1016/s0195-6701(99)90015-4 · Cited by 103
A 5‐year (2000–2004) epidemiological survey of Candida and non‐Candida yeast species causing vulvovaginal candidiasis in Graz, Austria
Paulitsch‐Fuchs, A. H., Weger, W., Ginter‐Hanselmayer, G., Marth, E., & Buzina, W. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01284.x · Cited by 102
Emergence of Saccharomyces cerevisiae as a human pathogen
Murphy, A., & Kavanagh, K. (1999) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(99)00086-1 · Cited by 98
“cerevisiae when used against two isolates obtained from patients with symptomatic vulvovaginitis [9].”
BackgroundInfluential
Vaginitis Due to Candida krusei: Epidemiology, Clinical Aspects, and Therapy
Singh, S., Sobel, J. D., Bhargava, P., Boikov, D. A., & Vazquez, J. A. (2002) · Clinical Infectious Diseases · doi:10.1086/343826 · Cited by 100
“Electrophoresis was performed on intact chromosomal DNA, prepared as described elsewhere [7].”
Self-citation
Saccharomyces cerevisiae: Population Divergence and Resistance to Oxidative Stress in Clinical, Domesticated and Wild Isolates
Diezmann, S., & Dietrich, F. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005317 · Cited by 91
“These infections are similar to those by the related yeast Candida albicans, the most common human fungal pathogen [20,34,35].”
Background
Safety assessment of dairy microorganisms: The hemiascomycetous yeasts
Jacques, N., & Casarégola, S. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.08.020 · Cited by 89
Saccharomyces boulardii Is Not Saccharomyces cerevisiae
McFarland, L. V. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.1.200 · Cited by 76
Comparativein vitroactivity of antimycotic agents against pathogenic vaginal yeast isolates
Lynch, M. E., & Sobel, J. D. (1994) · Medical Mycology · doi:10.1080/02681219480000341 · Cited by 71
Self-citation
Epidemiological Investigation of Vaginal Saccharomyces cerevisiae Isolates by a Genotypic Method
McCullough, M. J., Clemons, K. V., Farina, C., McCusker, J. H., & Stevens, D. A. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.2.557-562.1998 · Cited by 59
“(15) found that this condition was indistinguishable from the vulvovaginitis caused by the more commonly identified fungal pathogens belonging to the genus Candida.”
BackgroundResultInfluential
Synergistic antifungal activity of statin–azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification
Cabral, M. E., Figueroa, L. I. C., & Fariña, J. I. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2012.09.006 · Cited by 54
Comparative Analysis of the Capacity of the Candida Species To Elicit Vaginal Immunopathology
Willems, H. M. E., Lowes, D. J., Barker, K. S., Palmer, G. E., & Peters, B. M. (2018) · Infection and Immunity · doi:10.1128/iai.00527-18 · Cited by 56
“cerevisiae has been isolated as a causative agent of vaginitis (58).”
Background
In vitro susceptibility testing and DNA typing of Saccharomyces cerevisiae clinical isolates
Zerva, L., Hollis, R. J., & Pfaller, M. A. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.12.3031-3034.1996 · Cited by 54
“cerevisiae obtained from patients with vaginal infections (15) or oropharyngeal colonization (17).”
BackgroundResult
Vaginitis: Diagnosis and Management
Quan, M. A. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.11.2229 · Cited by 50
“If only budding spores (Figure 6) are seen in the absence of pseudohyphae in a symptomatic patient, the possibility of involvement of a non-albicans species, such as C glabrata and S cerevisiae, should be suspected.(49)”
Background
Molecular tools for differentiating probiotic and clinical strains of Saccharomyces cerevisiae
Posteraro, B., Sanguinetti, M., Romano, L., Torelli, R., Novarese, L., & Fadda, G. (2005) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.12.031 · Cited by 42
Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice
Hodgetts, S. J., Matthews, R., Morrissey, G., Mitsutake, K., Piper, P. W., & Burnie, J. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00140.x · Cited by 40
Typing of Saccharomyces cerevisiae Clinical Strains by Using Microsatellite Sequence Polymorphism
Malgoire, J. Y., Bertout, S., François Renaud, A., Bastide, J.-M., & Mallié, M. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.3.1133-1137.2005 · Cited by 40
“Saccharomyces cerevisiae is a saprophyte of the digestive, respiratory, and genitourinary tracts (2-4, 17, 18, 25).”
Background
vaginitis: Transmission from yeast used in baking
Nyirjesy, P., VAZQUEZ, J., Ufberg, D., Sobel, J. D., Boikov, D. A., & BUCKLEY, H. R. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00174-p · Cited by 39
Self-citation
In vivo virulence of commercial Saccharomyces cerevisiae strains with pathogenicity-associated phenotypical traits
de Llanos, R., Llopis, S., Molero, G., Querol, A., Gil, C., & Fernández-Espinar, M. T. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.10.025 · Cited by 37
“…(Enache-Angoulvant and Hennequin, 2005; Lolis et al., 2008; Montineri et al., 2008; Muñoz et al., 2005; Swinne et al., 2009; Williams et al., 2007); furthermore, it can sometimes even affect patients showing no obvious predisposition (Jensen et al., 1976; Smith et al., 2002; Sobel et al., 1993).”
Background
Clinicians' Use of Intravaginal Boric Acid Maintenance Therapy for Recurrent Vulvovaginal Candidiasis and Bacterial Vaginosis
Powell, A. M., Ghanem, K. G., Rogers, L. C., Zinalabedini, A., Brotman, R. M., Zenilman, J. M., & Tuddenham, S. (2019) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000001063 · Cited by 36
“Copyright © 2019 by the American Sexually Transmitted Diseases As use of longer term (over months) maintenance BA; however, regimens varied.(3,12) One study of intermittent therapy treated 92 women with refractory VVCwith 600-mg BA for 14 days, followed by once daily BA during menstruation for 4 months in 38 of the pa…”
Background
Review of current methods for characterizing virulence and pathogenicity potential of industrialSaccharomyces cerevisiaestrains towards humans
Anoop, V., Rotaru, S., Shwed, P. S., Tayabali, A. F., & Arvanitakis, G. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov057 · Cited by 35
“1 syr/article-abstract/15/6/fov057/635889 by guest on 15 M arch 2020 Sobel et al. 1993).”
Background
Molecular and Epidemiological Characterization of Vaginal Saccharomyces cerevisiae Isolates
Posteraro, B., Sanguinetti, M., D’Amore, G., Masucci, L., Morace, G., & Fadda, G. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.7.2230-2235.1999 · Cited by 34
“The increased use of vaginal and systemic azole agents, particularly fluconazole, which exhibits poor activity against this organism, has been reported as one of the major factors that may contribute to disease development (34).”
BackgroundInfluential
Population genomics reveals evolution and variation of Saccharomyces cerevisiae in the human and insects gut
Ramazzotti, M., Stefanini, I., Paola, M. D., Filippo, C. D., Rizzetto, L., Berná, L., Dapporto, L., Rivero, D., Tocci, N., Weil, T., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14422 · Cited by 35
Boric Acid Vaginal Suppositories: A Brief Review
Prütting, S., & Cerveny, J. D. (1998) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/s1064744998000386 · Cited by 33
Sensibilidad a antifúngicos de levaduras patógenas emergentes
García-Martos, P., Domínguez, I., Marín, P., García-Agudo, R., Aoufi, S., & Mira, J. (2001) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(01)72630-4 · Cited by 33
“…, teleomorfo de C. robusta , se ha implicado en endocarditis, peritonitis, infección del tracto urinario, vulvo-vaginitis, empiema, neumonía y fungemia 77-83 ; y T. beige-lii ( T. cutaneum ), recientemente clasificado en 5 especies, se ha descrito en casos de endocarditis y fungemia 84-87 .”
Colony phenotype switching in clinical and non-clinical isolates ofSaccharomyces cerevisiae
Clemons, K. V., Hanson, L. H., & Stevens, D. A. (1996) · Medical Mycology · doi:10.1080/02681219680000441 · Cited by 32
Saccharomyces cerevisiae infections and antifungal susceptibility studies by colorimetric and broth macrodilution methods
Tiballi, R. N., Spiegel, J. E., Zarins, L. T., & Kauffman, C. A. (1995) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/0732-8893(95)00188-3 · Cited by 31
VULVOVAGINITIS
Sobel, J. D. (1998) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70043-7 · Cited by 28
Self-citation
Application of DNA typing methods and genetic analysis to epidemiology and taxonomy of Saccharomyces isolates
Clemons, K. V., Park, P., McCusker, J. H., McCullough, M. J., Davis, R. W., & Stevens, D. A. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.7.1822-1828.1997 · Cited by 28
“In those studies, the isolates were strain typed by karyotyping, with each of the seven patients having a unique strain (35).”
BackgroundInfluential
The Flo Adhesin Family
Willaert, R., Kayacan, Y., & Devreese, B. V. (2021) · Pathogens · doi:10.3390/pathogens10111397 · Cited by 27
Curcumin as a potential non-steroidal contraceptive with spermicidal and microbicidal properties
Naz, R. K., & Lough, M. L. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.01.024 · Cited by 25
“cerevisiae has also been reported to cause opportunistic yeast infections with increasing frequency in recent years [30,31].”
Background
Infections caused by non- Candida , non- Cryptococcus yeasts
Pfaller, M. A., Diekema, D. J., & Merz, W. G. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00010-4 · Cited by 25
Quantitative agar-invasion assay
Zupan, J., & Raspor, P. (2008) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2008.02.009 · Cited by 23
“Symptoms are indistinguishable from those of invasive candidiasis (EnacheAngoulvant and Hennequin, 2005) and the fact that some strains can be resistant to fluconazole (Kontoyiannis and Rupp, 2000; Sobel et al., 1993) complicates treatment of invasive Saccharomyces infections.”
Background
Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro
Pérez‐Torrado, R., Llopis, S., Jespersen, L., Fernández-Espinar, M. T., & Querol, A. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.04.012 · Cited by 23
Allergic Bronchopulmonary Fungal Disease Caused bySaccharomyces cerevisiae
Ogawa, H., Fujimura, M., & Tofuku, Y. (2004) · Journal of Asthma · doi:10.1081/jas-120026080 · Cited by 23
“cerevisiae are few but include vaginitis (24,25), endocarditis, and pneumonia treated with prolonged antimycotic drug therapy.”
Background
Two Cases of Vaginitis Caused by Itraconazole-Resistant Saccharomyces cerevisiae and a Review of Recently Published Studies
Savini, V., Catavitello, C., Manna, A., Talia, M., Febbo, F., Balbinot, A., D’Antonio, F., Bonaventura, G. D., Celentano, C., Liberati, M., et al. (2008) · Mycopathologia · doi:10.1007/s11046-008-9119-y · Cited by 22
“cerevisiae vaginal infections is indistinguishable from the vulvovaginitis caused by fungi belonging to the genus Candida [3, 5, 17].”
Background
Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae
Nguyen, P. V., Plocek, V., Váchová, L., & Palková, Z. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-0118-1 · Cited by 22
“Saccharomyces invasive infections are often clinically similar to invasive candidiasis.(3) Clinical S.”
Background
Candida vulvovaginitis
Sobel, J. D. (1996) · Seminars in Dermatology · doi:10.1016/s1085-5629(96)80014-9 · Cited by 22
Self-citation
Brewer's Yeast and Saccharomyces boulardii Both Attenuate Clostridium difficile-Induced Colonic Secretion in the Rat
Izadnia, F., Wong, C., & Kocoshis, S. A. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018811331596 · Cited by 22
Vulvovaginal Candidosis (excluding chronic mucocutaneous candidosis). Guideline of the German Society of Gynecology and Obstetrics (AWMF Registry No. 015/072, S2k Level, December 2013)
Mendling, W., Friese, K., Mylonas, I. G., Weissenbacher, E. R., Brasch, J., Schaller, M., Mayser, P. A., Effendy, I., Ginter‐Hanselmayer, G., Hof, H., et al. (2015) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1545741 · Cited by 21
Saccharomyces cerevisiae: an Emerging and Model Pathogenic Fungus
McCusker, J. H. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch18 · Cited by 21
Oxidative Stress Survival in a Clinical Saccharomyces cerevisiae Isolate Is Influenced by a Major Quantitative Trait Nucleotide
Diezmann, S., & Dietrich, F. S. (2011) · Genetics · doi:10.1534/genetics.111.128256 · Cited by 21
“Notably, S. cerevisiae infections are indistinguishable from those caused by the most widely recognized fungal pathogen Candida albicans (Sobel et al. 1993; McNeil et al. 2001; Zaoutis et al. 2005).”
Background
Assessment and Treatment of Vaginitis
Mitchell, C. M. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005673 · Cited by 22
Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis): Guideline of the German (DGGG), Austrian (OEGGG) and Swiss (SGGG) Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry Number 015/072, September 2020)
Farr, A., Effendy, I., Tirri, B. F., Hof, H., Mayser, P. A., Petričević, L., Ruhnke, M., Schaller, M., Schäfer, A., Willinger, B., et al. (2021) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1345-8793 · Cited by 19
“Saccharomyces cerevisiae ist grundsätzlich apathogen und verursacht daher keine Beschwerden [20,21], auch wenn dieser im Sinne eines Kommensalismus in 1–2% der vaginalen Kulturen identifiziert werden kann [8,15].”
BackgroundInfluential
Discriminative power of fatty acid methyl ester (FAME) analysis using the Microbial Identification System (MIS) for Candida (Torulopsis) glabrata and Saccharomyces cerevisiae
Peltroche‐Llacsahuanga, H., Schmidt, S., Lütticken, R., & Haase, G. (2000) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(00)00205-4 · Cited by 19
Invasive growth of Saccharomyces cerevisiae depends on environmental triggers: a quantitative model
Zupan, J., & Raspor, P. (2010) · Yeast · doi:10.1002/yea.1746 · Cited by 19
“Besides, a resistance to some antifungal drugs, such as fluconazole, complicates the treatment (EnacheAngoulvant and Hennequin, 2005; Kontoyiannis and Rupp, 2000; Sobel et al., 1993).”
Background
Vaginal Mucormycosis: A Case Report
Sobel, J. D. (2001) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/s1064744901000205 · Cited by 19
Self-citation
Biochemical characteristics, virulence traits and antifungal resistance of two major yeast species isolated from kefir: Kluyveromyces marxianus and Saccharomyces unisporus
Lim, H., Kim, D., Jeong, D., Kang, I., Kim, H., & Seo, K. (2019) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12582 · Cited by 19
In vitroactivity of five antifungal agents against clinical isolates ofSaccharomyces cerevisiae
Barchiesi, F., Arzeni, D., Compagnucci, P., Francesco, L. F. D., Giacometti, A., & Scalise, G. (1998) · Medical Mycology · doi:10.1080/02681219880000701 · Cited by 19
Adherence of clinical isolates of Saccharomyces cerevisiae to buccal epithelial cells.
Murphy, A., & Kavanagh, K. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.123.127 · Cited by 13
Vulvovaginal Trichosporonosis
Makela, P., Leaman, D., & Sobel, J. D. (2003) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1080/10647440300025510 · Cited by 17
Self-citation
Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasis
Barnhart, K. T. (2005) · Current Medical Research and Opinion · doi:10.1185/030079904x18018 · Cited by 17
Vulvovaginitis and Cervicitis
McCormack, W. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00107-7 · Cited by 16
Sexual forms of yeasts in clinical samples
García-Martos, P., Mira, J., Galán‐Sánchez, F., & Hernández, J. M. (1996) · Mycopathologia · doi:10.1007/bf00437497 · Cited by 16
“Saccharomyces cerevisiae, whose anamorphic state is Candida robusta, has been implicated in isolated cases of respiratory infection [23, 31, 36-38], infection of the urinary tract [31 ], vulvovaginitis [25, 35, 40, 42], peritonitis [29, 30], empyema [41], endocarditis [24, 26] and fungemia [24, 26-28, 32-34, 37, 39].”
Background
Uncommon Yeasts and Molds Causing Human Disease
Shoff, C. J., & Perfect, J. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.21023-6 · Cited by 16
Identificación de especies de Candida causantes de vaginitis en la población mexicana
Rivera-Sánchez, R., Flores-Paz, R., & Arriaga‐Alba, M. (2006) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1157/13095375 · Cited by 15
Itraconazole in the treatment of acute and recurrent vulvovaginal candidosis: comparison of a 1‐day and a 3‐day regimen
Špaček, J., & Buchta, V. (2005) · Mycoses · doi:10.1111/j.1439-0507.2005.01099.x · Cited by 15
Data on Safety of Intravaginal Boric Acid Use in Pregnant and Nonpregnant Women: A Narrative Review
Mittelstaedt, R., Kretz, A., Levine, M., Handa, V. L., Ghanem, K. G., Sobel, J. D., Powell, A., & Tuddenham, S. (2021) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000001562 · Cited by 14
Self-citation
Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs
Sasivimolrattana, T., Chantratita, W., Sensorn, I., Chaiwongkot, A., Oranratanaphan, S., Bhattarakosol, P., & Bhattarakosol, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192214716 · Cited by 14
“infection caused vaginitis, but most of the cases were caused by Saccharomyces cerevisiae [53].”
Background
Treatment of vaginitis caused by non-albicans Candida species
Sobel, J. D. (2024) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2024.2347953 · Cited by 14
“Successful therapy with boric acid, often prolonged, is described [66].”
BackgroundSelf-citation
Molecular epidemiology of Saccharomyces cerevisiae in an immunocompromised host unit
Clemons, K. V., Salonen, J. H., Issakainen, J., NIKOSKELAINEN, J., McCullough, M. J., Jorge, J., & Stevens, D. A. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.06.010 · Cited by 14
“010 with increasing frequency as a cause of clinically relevant disease (Aucott et al., 1990; Cimolai et al., 1987; Clemons et al., 1997; Doyle et al., 1990; Eng et al., 1984; McCullough et al., 1998a; Nielsen et al., 1990; Nyirjesy et al., 1995; Olver et al., 2002; Ponton et al., 2000; Salonen et al., 2000; Sobel et…”
BackgroundInfluential
Boric acid susceptibility testing of non-C. albicans Candida and Saccharomyces cerevisiae: comparison of three methods
Otero, L., Palacio, V., Méndez, F. J., & Vazquez, F. (2002) · Medical Mycology · doi:10.1080/714031106 · Cited by 14
Brewer's Yeast as a Cause of Infection
Smith, D. L. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.1.201 · Cited by 12
“[12] described nine patients with vaginitis due to S.”
Background
Emerging Pathogens of the Candida Species
Yang, B., & Rao, R. P. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80378 · Cited by 10
“Although the recent rise in the number of these infections [5] is mainly associated to C.”
Background
Differences in activation of MAP kinases and variability in the polyglutamine tract of Slt2 in clinical and non‐clinical isolates of Saccharomyces cerevisiae
de Llanos, R., Hernández‐Haro, C., Barrio, E., Querol, A., Fernández-Espinar, M. T., & Molina, M. (2010) · Yeast · doi:10.1002/yea.1799 · Cited by 10
“Nevertheless, there are some cases where infections have been recorded in patients showing no obvious predisposition (Sobel et al., 1993; Smith et al., 2002).”
Background
Saccharomyces Cerevisiae Oesophagitis in an HIV-Infected Patient
Koneçny, P., Drummond, F., Tish, K. N., & TAPSALL, J. W. (1999) · International Journal of STD & AIDS · doi:10.1258/0956462991913475 · Cited by 10
Properties of Sustained-Release Single-Dose Formulations for Vulvovaginal Candidiasis
Henzl, M. R. (2005) · American Journal of Drug Delivery · doi:10.2165/00137696-200503040-00003 · Cited by 9
Saccharomyces cerevisiae show low levels of traversal across human endothelial barrier in vitro
Pérez‐Torrado, R., & Querol, A. (2017) · F1000Research · doi:10.12688/f1000research.11782.2 · Cited by 8
Rhodotorula, Saccharomyces, Malassezia, Trichosporon, Blastoschizomyces, and Sporobolomyces
Vazquez, J. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6640-7_13 · Cited by 8
Self-citation
Second trimester vaginal Candida colonization among pregnant women attending antenatal care in Bukavu, Democratic Republic of the Congo: prevalence, clinical correlates, risk factors and pregnancy outcomes
Mulinganya, G. M., Keyser, K. D., Mongane, J., Kampara, F., Vulder, A. D., Boelens, J., Duyvejonck, H., Hendwa, E., Kujirakwinja, Y., Bisimwa, G. B., et al. (2024) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2024.1339821 · Cited by 7
“Other species found in our study, C. famata , C. inconspicua , C. kefyr and S. cerevisiae , are less common to (very) rare causes of vaginitis (45, 46).”
Result
Determination of Minumum Inhibitory Concentrations of Candida Species Isolated from Vaginal Swab Specimens by Using Broth Macrodilution and E-test
Bırıncı, A., Saniç, A., & Durupınar, B. (2001) · Journal of Chemotherapy · doi:10.1179/joc.2001.13.1.43 · Cited by 7
Boric Acid for the Treatment of Vaginitis: New Possibilities Using an Old Anti‐Infective Agent: A Systematic Review
Müller, M. L., Petersen, C. D., & Saunte, D. M. L. (2024) · Dermatologic Therapy · doi:10.1155/2024/2807070 · Cited by 6
Saccharomyces cerevisiae show low levels of traversal across the human blood brain barrier in vitro
Pérez‐Torrado, R., & Querol, A. (2017) · F1000Research · doi:10.12688/f1000research.11782.1 · Cited by 6
Vulvovaginitis and Cervicitis
McCormack, W. M., & Augenbraun, M. H. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00110-7 · Cited by 7
The future of non-invasive azole antifungal treatment options for the management of vulvovaginal candidiasis
Quindós, G., Marcos‐Arias, C., Miranda-Cadena, K., Sevillano, E., Jauregizar, N., Schneider, J., & Eraso, E. (2025) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2025.2516554 · Cited by 5
Phytochemical Screening and Antibacterial/Antifungal Activities of Ginkgo biloba Extract EGb 761
Ibrahim, M. P., & Nuhu, A. A. (2016) · Cited by 5
Presença de leveduras em mucosas e fezes de indivíduos aparentemente saudáveis e de pessoas com sintomas de infecção fúngica
Silva, J. O., Franceschini, S. A., & Cândido, R. C. (2002) · REVISTA DO INSTITUTO ADOLFO LUTZ · doi:10.53393/rial.2002.61.34994 · Cited by 5
Untargeted Metabolomic Analysis of Cell-Free Supernatants (CFSs) from Different Clinical Isolates of Saccharomyces cerevisiae and Their Effects on Candida albicans Virulence
Spaggiari, L., Tedeschi, G., Benatti, G., Benedittis, M. D., Franzè, M. T., Pinetti, D., Pericolini, E., & Ardizzoni, A. (2026) · Journal of Fungi · doi:10.3390/jof12020081 · Cited by 4
“…of S. cerevisiae in human-related environments and its wide employment in the food industry allowed it to adapt to several body sites where it normally dwells as a commensal, such as skin [9], mucosal membranes [10,11], breast milk [12], and respiratory [13,14] and intestinal tracts [11,15,16].”
Fungal infections of the genitourinary tract
Sobel, J. D. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00026-8 · Cited by 4
Self-citation
Aetiology of Vulvovaginal Candidiasis in Ecuador and In Vitro Antifungal Activity Against Candida Vaginal Isolates
Bowen, C., Marcos‐Arias, C., Checa, C., Castellanos, M. E., Miranda-Cadena, K., Eraso, E., & Quindós, G. (2025) · Journal of Fungi · doi:10.3390/jof11100742 · Cited by 4
“Some studies suggest that its virulence may be due to its association with C. albicans as a co-pathogen, similar to C. glabrata [49,54].”
Quatre heures pour un record, ou une cellulite vraiment foudroyante: Saccharomyces cerevisiœ peutelle en être la cause?
Almanza, L., Debien, B., Fontaine, B., & Brinquin, L. (1998) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/s0750-7658(98)80061-0 · Cited by 3
The Vaginal Microbiome
(2016) · doi:10.1128/9781555819071.ch12 · Cited by 3
Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model
Hernández‐Haro, C., Llopis, S., Molina, M., Monteoliva, L., & Gil, C. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.08.008 · Cited by 3
Mycotoxins, fungus and ‘electrohypersensitivity’
Anttila, K. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.1045 · Cited by 3

Authors: Sobel, J. D., Vazquez, J., Lynch, M., Meriwether, C., & Zervos, M. J.
Affiliations: Wayne State University (US)
Corresponding author: Sobel, J. D.
ORCID: Sobel, J. D.
Zervos, M. J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 1993-01-01
Volume: 16
Issue: 1
Pages: 93-99
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/clinids/16.1.93
OpenAlex: W2109797093
Cited by: 117
References: 19
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 4
FWCI: 4.96
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Saccharomyces cerevisiae, vaginal candidiasis, vaginal infection, recurrent vaginitis, Candida albicans, azole resistance, fluconazole resistance, Candida glabrata, relapse versus reinfection, vaginal colonization, antifungal therapy
MeSH terms: Adult, Antifungal Agents, Female, Humans, Microbial Sensitivity Tests, Middle Aged, Mycoses, Recurrence, Saccharomyces cerevisiae, Vagina, Vaginitis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vaginitis due to Saccharomyces cerevisiae: epidemiology, clinical aspects and therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks