Clearance of Funguria with Short-Course Antifungal Regimens: A Prospective, Randomized, Controlled Study
Abstract
The effects of short-course antifungal regimens on funguria were studied in 180 hospitalized adults who did not have ascending urinary or deep fungal infections but did have > 1,000 cfu of yeast/mL in two consecutive urine cultures. Before treatment, efforts were made to eliminate factors conducive to funguria. No additional interventions were implemented in the management of the control group (group A), whereas five experimental groups received short-course therapy as follows: oral administration of fluconazole (group B); single-dose intravenous administration of amphotericin B (group C); and intermittent bladder irrigation with amphotericin B at low, medium, and high concentrations (groups D, E, and F, respectively). Urine was cultured on days 1 and 7 after antifungal treatment. The rate of spontaneous clearance of funguria in the control group was 40.0%. Rates of clearance in experimental groups B through F were 58.6%, 55.2%, 82.1% (P < .01), 86.7% (P < .001), and 83.3% (P < .001), respectively, on day 1 and 77.3% (P < .01), 72.0% (P < .05), 42.9%, 68.4%, and 68.2% (P < .05), respectively, on day 7. The decrement in yeast count was 60.8% for the control group. Decrements for experimental groups B through F were 80.5%, 74.2%, 94.2% (P < .01), 86.7% (P < .05), and 95.3% (P < .001), respectively, on day 1 and 85.5% (P < .05), 80.7%, 75.7%, 87.9% (P < .05), and 76.4%, respectively, on day 7.(ABSTRACT TRUNCATED AT 250 WORDS)
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Bladder irrigation with amphotericin B deoxycholate may transiently clear funguria.
“Bladder irrigation with amphotericin B deoxycholate (50-200 mg/mL) may transiently clear funguria [174]”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [174]
Cites
Urinary Tract Infections Due to Candida albicans
Fisher, J. F., Chew, W. H., Shadomy, S., Duma, R. J., Mayhan, C. G., & House, W. C. (1982) · Clinical Infectious Diseases · doi:10.1093/clinids/4.6.1107 · Cited by 158 · see citing works
Wong‐Beringer, A. (1992) · JAMA · doi:10.1001/jama.1992.03480200088030 · Cited by 47 · see citing works
Flucytosine in the Management of Genitourinary Candidiasis: 5 Years of Experience
Wise, G. J., Kozinn, P. J., & Goldberg, P. K. (1980) · The Journal of Urology · doi:10.1016/s0022-5347(17)55301-x · Cited by 45 · see citing works
Clearance of Candida colonizing the urinary bladder by a two-day amphotericin B irrigation
Hsu, C.-P., & Ukleja, B. (1990) · Infection · doi:10.1007/bf01647004 · Cited by 35 · see citing works
Sanford, J. P. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/16.1.145 · Cited by 35 · see citing works
Fisher, J. F., Hicks, B. C., DiPiro, J. T., Venable, J., & Fincher, R. M. E. (1987) · The Journal of Infectious Diseases · doi:10.1093/infdis/156.4.685 · Cited by 35 · see citing works
Fungal Cystitis: Awareness, Diagnosis and Treatment
Rohner, T. J., & Tuliszewski, R. M. (1980) · The Journal of Urology · doi:10.1016/s0022-5347(17)55334-3 · Cited by 28 · see citing works
Fong, I. W., Cheng, P.-S., & HINTON, N. A. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.9.1856 · Cited by 27 · see citing works
Successful Use of Fluconazole for Treatment of Urinary Tract Fungal Infections
Tacker, J. R. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)37073-8 · Cited by 14 · see citing works
[Clinical efficacy of fluconazole in urinary tract fungal infections].
Nito, H. (1989) · PubMed · Cited by 11 · see citing works
Nosocomial Funguria: Resultant Morbidity and Therapeutic Intervention
Wong‐Beringer, A., Jacobs, R. A., & Guglielmo, B. J. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.6.1066-a · Cited by 9 · see citing works
Bladder Irrigation with Amphotericin B for Treatment of Patients with Candiduria
Occhipinti, D. J., Schoonover, L. L., & Danziger, L. H. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.4.812 · Cited by 9 · see citing works
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Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Practice Guidelines for the Treatment of Candidiasis
Rex, J. H., Walsh, T. J., Sobel, J. D., Filler, S. G., Pappas, P. G., Dismukes, W. E., & Edwards, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313749 · Cited by 927 · see citing works
Prospective Multicenter Surveillance Study of Funguria in Hospitalized Patients
Kauffman, C. A., Vazquez, J. A., Sobel, J. D., Gallis, H. A., McKinsey, D. S., Karchmer, A. W., Sugar, A. M., Sharkey, P. K., Wise, G. J., Mangi, R., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/313583 · Cited by 483 · see citing works
Edwards, Jr., Bodey, G. P., Bowden, R. A., Buchner, T., de Pauw, B. E., Filler, S. G., Ghannoum, M. A., Glauser, M., Herbrecht, R., Kauffman, C. A., et al. (1997) · Clinical Infectious Diseases · doi:10.1086/514504 · Cited by 418 · see citing works
Candiduria: A Randomized, Double-Blind Study of Treatment with Fluconazole and Placebo
Sobel, J. D., Kauffman, C. A., McKinsey, D., Zervos, M., Vazquez, J. A., Karchmer, A. W., Lee, J., Thomas, C., Panzer, H., Dismukes, W. E., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/313580 · Cited by 343 · see citing works
Nosocomial Candiduria: A Review
Weinstein, R. A., Lundstrom, T., & Sobel, J. (2001) · Clinical Infectious Diseases · doi:10.1086/320531 · Cited by 221 · see citing works
Jacobs, L. G., Skidmore, E. A., Freeman, K., Lipschultz, D., & Fox, N. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.1.30 · Cited by 113 · see citing works
Vazquez, J. A., & Sobel, J. D. (2002) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00042-9 · Cited by 104 · see citing works
- Authors
- Leu, H.-S., & Huang, C.-T.
- Affiliations
- Chang Gung Memorial Hospital (TW)
- Corresponding author
- Leu, H.-S.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-05-01
- Volume
- 20
- Issue
- 5
- Pages
- 1152-1157
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2110016113
- Cited by
- 93
- References
- 12
- Citations by year
- 2026: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 1
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chang Gung Medical Foundation
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- funguria, fluconazole, amphotericin B, spontaneous clearance, hospitalized adults
- MeSH terms
- Aged, Amphotericin B, Female, Fungi, Humans, Male, Middle Aged, Mycoses, Prospective Studies, Urine, Fluconazole
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