CoChat
Sign Up
Cited by 343Antifungal resistance and susceptibilityUrinary Tract Infections ManagementOcular Infections and Treatments

Candiduria: A Randomized, Double-Blind Study of Treatment with Fluconazole and Placebo

Sobel, J. D., Kauffman, C. A., McKinsey, D., Zervos, M., Vazquez, J. A., Karchmer, A. W., Lee, J., Thomas, C. +3 more·2000·Clinical Infectious Diseases
DOI 10.1086/313580
Open this paper in CoChat — free account

Abstract

Management of candiduria is limited by the lack of information about its natural history and lack of data from controlled studies on the efficacy of treating it with antimycotic agents. We compared fungal eradication rates among 316 consecutive candiduric (asymptomatic or minimally symptomatic) hospitalized patients treated with fluconazole (200 mg) or placebo daily for 14 days. In an intent-to-treat analysis, candiduria cleared by day 14 in 79 (50%) of 159 receiving fluconazole and 46 (29%) of 157 receiving placebo (P<.001), with higher eradication rates among patients completing 14 days of therapy (P<.0001), including 33 (52%) of 64 catheterized and 42 (78%) of 54 noncatheterized patients. Pretreatment serum creatinine levels were inversely related to candiduria eradication. Fluconazole initially produced high eradication rates, but cultures at 2 weeks revealed similar candiduria rates among treated and untreated patients. Oral fluconazole was safe and effective for short-term eradication of candiduria, especially following catheter removal. Long-term eradication rates were disappointing and not associated with clinical benefit.

Integrity signals

Registry

Crossref · 10.1086/313580

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Discontinuation of catheter use alone may result in eradication of candiduria in almost 40% of patients.

    “However, discontinuation of catheter use alone may result in eradication of candiduria in almost 40% of patients [168] (B-III).”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [168]

  • Fluconazole (200 mg/day for 14 days) hastened the time to negative urine culture but the frequency of negative urine culture results was the same in both treatment groups 2 weeks after the end of therapy.

    “A recently completed placebo-controlled trial found that fluconazole (200 mg/day for 14 days) hastened the time to negative results of urine culture but that the frequency of negative urine culture results was the same in both treatment groups 2 weeks after the end of therapy (∼60% for catheterized patients and ∼73% for noncatheterized patients) [168].”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [168]

  • Treatment with fluconazole will briefly clear funguria in approximately one-half of treated patients, but recurrence is prompt, selection of resistant Candida species is possible, and therapy does not appear to alter clinical outcome.

    “Treatment with fluconazole will briefly clear funguria in approximately one-half of treated patients, but recurrence is prompt, selection of resistant Candida species is possible, and therapy does not appear to alter clinical outcome [168].”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [168]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Sobel, J. D., Kauffman, C. A., McKinsey, D., Zervos, M., Vazquez, J. A., Karchmer, A. W., Lee, J., Thomas, C., Panzer, H., Dismukes, W. E., & the National Institute of Allergy and Infectious Diseases (NIAID) Mycoses Study Group
Affiliations
  • Wayne State University (US)
  • University of Michigan (US)
  • Harvard University (US)
  • University of Alabama at Birmingham (US)
  • Pfizer (United States) (US)
Corresponding author
Sobel, J. D.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2000-01-01
Volume
30
Issue
1
Pages
19-24
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/313580
OpenAlex
W2138978805
Cited by
343
References
26
Citations by year
2026: 7 · 2025: 1 · 2024: 7 · 2023: 19 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 14 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 19 · 2014: 12 · 2013: 19 · 2012: 10
FWCI
14.66
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (N01-A1-15082)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
candiduria, fluconazole, candidemia, antifungal therapy, fungal eradication, urinary catheter, serum creatinine, hospitalized patients, treatment efficacy
MeSH terms
Aged, Antifungal Agents, Candida, Candida albicans, Candidiasis, Double-Blind Method, Female, Humans, Male, Urinary Tract Infections, Urine, Fluconazole, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review