The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Loss of cardioprotection with ageing
Abstract
Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is higher in older than in young humans, and the demographic shift towards an ageing population will further increase the prevalence of age-related cardiovascular disease. In order to develop strategies aimed to limit reversible and irreversible myocardial damage in older patients, there is a need to better understand age-induced alterations in protein expression and cell signalling. Cardioprotective phenomena such as ischaemic and pharmacological pre and postconditioning attenuate ischaemia/reperfusion injury in young hearts. Whether or not pre and postconditioning are still effective in aged organs, animals, or patients, i.e. under conditions where such cardioprotection is most relevant, is still a matter of debate; most studies suggest a loss of protection in aged hearts. The present review discusses changes in protein expression and cell signalling important to ischaemia/reperfusion injury with myocardial ageing. The efficacy of cardioprotective manoeuvres, e.g. ischaemic pre and postconditioning in aged organs and animals will be discussed, and the development of strategies aimed to antagonize the age-induced loss of protection will be addressed.
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Cites
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Cited by
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Ovize, M., Baxter, G. F., Di Lisa, F., Ferdinandy, P., Garcia-Dorado, D., Hausenloy, D. J., Heusch, G., Vinten-Johansen, J., Yellon, D. M., & Schulz, R. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq129 · Cited by 502
Self-citationBøtker, H. E., Hausenloy, D., Andreadou, I., Antonucci, S., Boengler, K., Davidson, S. M., Deshwal, S., Devaux, Y., Di Lisa, F., Di Sante, M., et al. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0696-8 · Cited by 423
Self-citationSanada, S., Komuro, I., & Kitakaze, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00553.2011 · Cited by 381
Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
Hausenloy, D. J., Barrabes, J. A., Bøtker, H. E., Davidson, S. M., Di Lisa, F., Downey, J., Engstrom, T., Ferdinandy, P., Carbrera-Fuentes, H. A., Heusch, G., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0588-8 · Cited by 308
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Metadata
- Authors
- Boengler, K., Schulz, R., & Heusch, G.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-28
- Volume
- 83
- Issue
- 2
- Pages
- 247-261
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2127583356
- Cited by
- 328
- References
- 16
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Open access
- closed
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