The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.
Insulin says NO to cardiovascular disease
Abstract
It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin has been used as an essential therapeutic agent in diabetes for blood glucose management. Recent studies demonstrate that insulin signalling is essential for normal cardiovascular function, and lack of it (i.e. insulin resistance) will result in cardiovascular dysfunction and disease. Moreover, insulin is the key component of glucose-insulin-potassium cocktail and exerts significant cardiovascular protective effect via a phosphatidylinositol 3'-kinase-protein kinase B-endothelial nitric oxide synthase (PI3K-Akt-eNOS)-dependent signalling mechanism in addition to its metabolic modulation, which renders it a potent organ protector in multiple clinical applications. This review focuses on insulin-initiated PI3K-Akt-eNOS survival signalling, with nitric oxide as an 'end effector' delivering cardioprotection in health and disease (especially in ischaemic heart disease), and highlights the impairment of this survival signalling as a key link between insulin resistance and cardiovascular disease.
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“The insulin receptor shares a signaling pathway with the activation of endothelial NOS (eNOS) [19,48,49,50,51,52] to regulate the postprandial blood flow and efficient nutrient disposition to peripheral tissues”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [51]
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Cites
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Cited by
Sorted by citations
Ageing as a Risk Factor for Disease
Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831
Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint
Boucher, J., Kleinridders, A., & Kahn, C. R. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009191 · Cited by 1,550
Gast, K. B., Tjeerdema, N., Stijnen, T., Smit, J. W. A., & Dekkers, O. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052036 · Cited by 403
Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments
Xiang, M., Lu, Y., Xin, L., Gao, J., Shang, C., Jiang, Z., Lin, H., Fang, X., Qu, Y., Wang, Y., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6614009 · Cited by 309
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274
“mediated activation of NOS3 [185].”
Metadata
- Authors
- Yu, Q., Gao, F., & Ma, X. L.
- Affiliations
- Xijing Hospital (CN)
- Thomas Jefferson University (US)
- Corresponding author
- Gao, F.
- Ma, X. L.
- ORCID
- Yu, Q.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-04
- Volume
- 89
- Issue
- 3
- Pages
- 516-524
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2019407178
- Semantic Scholar
- 7937e8f40b97ed3ed36508bc9198f0624094673d
- Cited by
- 172
- References
- 94
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 16 · 2012: 23
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- insulin resistance, cardiovascular disease, insulin signaling, PI3K/Akt/eNOS pathway, nitric oxide, cardioprotection, ischemic heart disease, type 2 diabetes, obesity, endothelial function
- MeSH terms
- Animals, Diabetic Angiopathies, Humans, Insulin, Insulin Resistance, Nitric Oxide, Myocardial Ischemia
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