Cited by 172Nitric Oxide and Endothelin EffectsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

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Insulin says NO to cardiovascular disease

Yu, Q., Gao, F., Ma, X. L.·2011·Cardiovascular Research

DOI 10.1093/cvr/cvq349

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Abstract

It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin has been used as an essential therapeutic agent in diabetes for blood glucose management. Recent studies demonstrate that insulin signalling is essential for normal cardiovascular function, and lack of it (i.e. insulin resistance) will result in cardiovascular dysfunction and disease. Moreover, insulin is the key component of glucose-insulin-potassium cocktail and exerts significant cardiovascular protective effect via a phosphatidylinositol 3'-kinase-protein kinase B-endothelial nitric oxide synthase (PI3K-Akt-eNOS)-dependent signalling mechanism in addition to its metabolic modulation, which renders it a potent organ protector in multiple clinical applications. This review focuses on insulin-initiated PI3K-Akt-eNOS survival signalling, with nitric oxide as an 'end effector' delivering cardioprotection in health and disease (especially in ischaemic heart disease), and highlights the impairment of this survival signalling as a key link between insulin resistance and cardiovascular disease.

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“mediated activation of NOS3 [185].”

See all 172

Authors: Yu, Q., Gao, F., & Ma, X. L.
Affiliations: Xijing Hospital (CN)
Thomas Jefferson University (US)
Corresponding author: Gao, F.
Ma, X. L.
ORCID: Yu, Q.
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2010-11-04
Volume: 89
Issue: 3
Pages: 516-524
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1093/cvr/cvq349
OpenAlex: W2019407178
Semantic Scholar: 7937e8f40b97ed3ed36508bc9198f0624094673d
Cited by: 172
References: 94
Citations by year: 2026: 7 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 16 · 2012: 23
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: insulin resistance, cardiovascular disease, insulin signaling, PI3K/Akt/eNOS pathway, nitric oxide, cardioprotection, ischemic heart disease, type 2 diabetes, obesity, endothelial function
MeSH terms: Animals, Diabetic Angiopathies, Humans, Insulin, Insulin Resistance, Nitric Oxide, Myocardial Ischemia

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