Insulin says NO to cardiovascular disease

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

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Regular Physical Activity Improves Endothelial Function in Patients With Coronary Artery Disease by Increasing Phosphorylation of Endothelial Nitric Oxide Synthase

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Cardiovascular Actions of Insulin

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Ageing as a Risk Factor for Disease

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Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint

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Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis

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Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments

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Regulation of obesity and insulin resistance by nitric oxide

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First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas

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New insights into the role of adipose tissue in thrombosis

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The Cardioprotection of the Insulin-Mediated PI3K/Akt/mTOR Signaling Pathway

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Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

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Optimization of Cardiac Metabolism in Heart Failure

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The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: An update

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Leptin and the regulation of endothelial function in physiological and pathological conditions

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Noncoding RNA in age-related cardiovascular diseases

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Transplantation of Hearts Donated after Circulatory Death

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The Mammalian Tribbles Homolog TRIB3, Glucose Homeostasis, and Cardiovascular Diseases

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Integrative Proteomics and Targeted Transcriptomics Analyses in Cardiac Endothelial Cells Unravel Mechanisms of Long-Term Radiation-Induced Vascular Dysfunction

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Nitric oxide system and diabetic nephropathy

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An Overview of NO Signaling Pathways in Aging

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TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

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Membrane receptor‐dependent N otch1/ H es1 activation by melatonin protects against myocardial ischemia–reperfusion injury: in vivo and in vitro studies

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NO-Rich Diet for Lifestyle-Related Diseases

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Anti-obesity and anti-diabetic effects of nitrate and nitrite

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Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion

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Role of elastin peptides and elastin receptor complex in metabolic and cardiovascular diseases

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mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1

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iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation

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The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

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Baicalin Protects the Cardiomyocytes from ER Stress-Induced Apoptosis: Inhibition of CHOP through Induction of Endothelial Nitric Oxide Synthase

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Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes

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Metformin Therapy in Diabetes: The Role of Cardioprotection

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Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

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Direct Evidence that Myocardial Insulin Resistance following Myocardial Ischemia Contributes to Post-Ischemic Heart Failure

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JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.

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p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

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Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction

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Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms

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PCSK9 in metabolism and diseases

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β-Adrenergic Receptor and Insulin Resistance in the Heart

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Egg consumption and cardiovascular disease among diabetic individuals: a systematic review of the literature

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Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis

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Propionyl-L-carnitine Corrects Metabolic and Cardiovascular Alterations in Diet-Induced Obese Mice and Improves Liver Respiratory Chain Activity

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Dietary nitrite attenuates oxidative stress and activates antioxidant genes in rat heart during hypobaric hypoxia

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Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway

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Insulin ameliorates miR-1-induced injury in H9c2 cells under oxidative stress via Akt activation

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Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation

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Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats

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The role of inflammation in diabetic cardiomyopathy

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Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis

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Review focus on inorganic nitrite and nitrate in cardiovascular health and disease

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Role of the Autonomic Nervous System in the Hemodynamic Response to Hyperinsulinemia—Implications for Obesity and Insulin Resistance

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Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells

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Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice

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Overnourishment during lactation induces metabolic and haemodynamic heart impairment during adulthood

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Copanlisib for the Treatment of Malignant Lymphoma: Clinical Experience and Future Perspectives

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Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation

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Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart

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Effect of anthocyanins on metabolic syndrome through interacting with gut microbiota

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Obesity induced by high fat diet attenuates postinfarct myocardial remodeling and dysfunction in adult B6D2F1 mice

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Effect of Deuterium-Depleted Water on Selected Cardiometabolic Parameters in Fructose-Treated Rats

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Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats

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Upregulated hepatokine fetuin B aggravates myocardial ischemia/reperfusion injury through inhibiting insulin signaling in diabetic mice

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Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance

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Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy

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Insulin resistance and inflammation markers in myocardial infarction

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Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs

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Modified Glucose‐Insulin‐Potassium Regimen Provides Cardioprotection With Improved Tissue Perfusion in Patients Undergoing Cardiopulmonary Bypass Surgery

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Insulin protects H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210

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Heat shock protein 90/Akt pathway participates in the cardioprotective effect of exogenous hydrogen sulfide against high glucose-induced injury to H9c2 cells

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Resistance exercise acutely enhances mesenteric artery insulin-induced relaxation in healthy rats

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The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells

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The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond

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The cardiovascular effects of insulin

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TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice

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ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance

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Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study

Effoe, V. S., Wagenknecht, L. E., Echouffo-Tcheugui, J. B., Chen, H., Joseph, J. J., Kalyani, R. R., Bell, R. A., Wu, W.-C. H., Casanova, R., & Bertoni, A. G. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004229 · Cited by 20

Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia

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