The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation
Abstract
Structural remodelling occurring before, due to the underlying heart disease, and during atrial fibrillation (AF) sets the stage for permanent AF. Current therapy in AF aims to maintain sinus rhythm in symptomatic patients, but outcome is unfortunately poor. Stretch of the atria is a main contributor to atrial remodelling. In this review, we describe different aspects of structural remodelling as seen in animal models and in patients with AF, including atrial enlargement, cellular hypertrophy, dedifferentiation, fibrosis, apoptosis, and loss of contractile elements. In the second part, we describe downstream signals of mechanical stretch and their contribution to AF and structural remodelling. Ultimately, knowledge of mechanisms underlying structural remodelling may help to identify new pharmacological targets for AF prevention.
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Atrial Fibrillation Begets Atrial Fibrillation: A Study in Awake Chronically Instrumented Goats
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The journal of clinical investigation
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Heijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014) · Circulation Research · doi:10.1161/circresaha.114.302226 · Cited by 677
Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model
Kamel, H., Okin, P. M., Elkind, M. S. V., & Iadecola, C. (2016) · Stroke · doi:10.1161/strokeaha.115.012004 · Cited by 627
Ben-Hail, D., Begas-Shvartz, R., Shalev, M., Shteinfer-Kuzmine, A., Gruzman, A., Reina, S., De Pinto, V., & Shoshan-Barmatz, V. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744284 · Cited by 158
Anter, E., Di Biase, L., Contreras-Valdes, F. M., Gianni, C., Mohanty, S., Tschabrunn, C. M., Viles-Gonzalez, J. F., Leshem, E., Buxton, A. E., Kulbak, G., et al. (2017) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005407 · Cited by 127
Metadata
- Authors
- De Jong, A. M., Maass, A. H., Oberdorf-Maass, S. U., Van Veldhuisen, D. J., Van Gilst, W. H., & Van Gelder, I. C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-11
- Volume
- 89
- Issue
- 4
- Pages
- 754-765
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2003419452
- Cited by
- 269
- References
- 121
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- De Jong, A. M., Maass, A. H., Oberdorf-Maass, S. U., Van Veldhuisen, D. J., Van Gilst, W. H., & Van Gelder, I. C. (2011). Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation. Cardiovascular Research. https://doi.org/10.1093/cvr/cvq357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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