The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart
Open accessAbstract
AIMS: The objective of this study was to investigate whether vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSC) improves myocardial survival and the engraftment of implanted MSC in infarcted hearts and promotes recruitment of stem cells through paracrine release of myocardial stromal cell-derived factor-1α (SDF-1α). METHODS AND RESULTS: VEGF-expressing MSC ((VEGF)MSC)-conditioned medium enhanced SDF-1α expression in heart slices and H9C2 cardiomyoblast cells via VEGF and the vascular endothelial growth factor receptor (VEGFR). The (VEGF)MSC-conditioned medium markedly promoted cardiac stem cell (CSC) migration at least in part via the SDF-1α/CXCR4 pathway and involved binding to VEGFR-1 and VEGFR-3. In vivo, (VEGF)MSC-stimulated SDF-1α expression in infarcted hearts resulted in massive mobilization and homing of bone marrow stem cells and CSC. Moreover, VEGF-induced SDF-1α guided the exogenously introduced CSC in the atrioventricular groove to migrate to the infarcted area, leading to a reduction in infarct size. Functional studies showed that (VEGF)MSC transplantation stimulated extensive angiomyogenesis in infarcted hearts as indicated by the expression of cardiac troponin T, CD31, and von Willebrand factor and improved the left ventricular performance, whereas blockade of SDF-1α or its receptor by RNAi or antagonist significantly diminished the beneficial effects of (VEGF)MSC. CONCLUSION: Exogenously expressed VEGF promotes myocardial repair at least in part through SDF-1α/CXCR4-mediated recruitment of CSC.
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. D. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Gnecchi, M., Zhang, Z., Ni, A., & Dzau, V. J. (2008) · Circulation Research · doi:10.1161/circresaha.108.176826 · Cited by 2,027
Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677
Self-citationAskari, A. T., Unzek, S., Popovic, Z. B., Goldman, C. K., Forudi, F., Kiedrowski, M., Rovner, A., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14232-8 · Cited by 1,270
Gnecchi, M., He, H., Noiseux, N., Liang, O. D., Zhang, L., Morello, F., Mu, H., Melo, L. G., Pratt, R. E., Ingwall, J. S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5211com · Cited by 1,157
Self-citationHow do stem cells find their way home?
Lapidot, T., Dar, A., & Kollet, O. (2005) · Blood · doi:10.1182/blood-2005-04-1417 · Cited by 985
Silva, G. V., Litovsky, S., Assad, J. A. R., Sousa, A. L. S., Martin, B. J., Vela, D., Coulter, S. C., Lin, J., Ober, J., Vaughn, W. K., et al. (2005) · Circulation · doi:10.1161/01.cir.0000151812.86142.45 · Cited by 801
Abbott, J. D., Huang, Y., Liu, D., Hickey, R., Krause, D. S., & Giordano, F. J. (2004) · Circulation · doi:10.1161/01.cir.0000147780.30124.cf · Cited by 783
Self-citationURBICH, C., AICHER, A., HEESCHEN, C., DERNBACH, E., HOFMANN, W., ZEIHER, A., & DIMMELER, S. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.07.003 · Cited by 741
Cited by
Mesenchymal Stem Cell Migration and Tissue Repair
Fu, X., Liu, G., Halim, A., Ju, Y., Luo, Q., & Song, G. (2019) · Cells · doi:10.3390/cells8080784 · Cited by 1,044
Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives
Liang, X., Ding, Y., Zhang, Y., Tse, H.-F., & Lian, Q. (2014) · Cell Transplantation · doi:10.3727/096368913x667709 · Cited by 909
Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review
Margiana, R., Markov, A., Zekiy, A. O., Hamza, M. U., Al-Dabbagh, K. A., Al-Zubaidi, S. H., Hameed, N. M., Ahmad, I., Sivaraman, R., Kzar, H. H., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03054-0 · Cited by 429
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Döring, Y., Pawig, L., Weber, C., & Noels, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00212 · Cited by 289
Liu, H., Liu, S., Li, Y., Wang, X., Xue, W., Ge, G., & Luo, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034608 · Cited by 262
Metadata
- Authors
- Tang, J.-M., Wang, J.-N., Zhang, L., Zheng, F., Yang, J.-Y., Kong, X., Guo, L.-Y., Chen, L., Huang, Y.-Z., Wan, Y., & Chen, S.-Y.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-22
- Volume
- 91
- Issue
- 3
- Pages
- 402-411
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2073319647
- Cited by
- 259
- References
- 36
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tang, J.-M., Wang, J.-N., Zhang, L., Zheng, F., Yang, J.-Y., Kong, X., Guo, L.-Y., Chen, L., Huang, Y.-Z., Wan, Y., & Chen, S.-Y. (2011). VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovascular Research. https://doi.org/10.1093/cvr/cvr053
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
