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Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis
Open accessAbstract
In the present review, we describe the causes and consequences of loss of vascular smooth muscle cells (VSMCs) or their function in advanced atherosclerotic plaques and discuss possible mechanisms such as cell death or senescence, and induction of autophagy to promote cell survival. We also highlight the potential use of pharmacological modulators of these processes to limit plaque progression and/or improve plaque stability. VSMCs play a pivotal role in atherogenesis. Loss of VSMCs via initiation of cell death leads to fibrous cap thinning and promotes necrotic core formation and calcification. VSMC apoptosis is induced by pro-inflammatory cytokines, oxidized low density lipoprotein, high levels of nitric oxide and mechanical injury. Apoptotic VSMCs are characterized by a thickened basal lamina surrounding the cytoplasmic remnants of the VSMC. Inefficient clearance of apoptotic VSMCs results in secondary necrosis and subsequent inflammation. A critical determinant in the VSMC stress response and phenotypic switching is autophagy, which is activated by various stimuli, including reactive oxygen and lipid species, cytokines, growth factors and metabolic stress. Successful autophagy stimulates VSMC survival, whereas reduced autophagy promotes age-related changes in the vasculature. Recently, an interesting link between autophagy and VSMC senescence has been uncovered. Defective VSMC autophagy accelerates not only the development of stress-induced premature senescence but also atherogenesis, albeit without worsening plaque stability. VSMC senescence in atherosclerosis is likely a result of replicative senescence and/or stress-induced premature senescence in response to DNA damaging and/or oxidative stress-inducing stimuli. The finding that VSMC senescence can promote atherosclerosis further illustrates that normal, adequate VSMC function is crucial in protecting the vessel wall against atherosclerosis.
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“Furthermore, targeting autophagy demonstrates bidirectional therapeutic potential in vascular pathologies.While autophagy induction may protect against endothelial dysfunction and hypertension, autophagy-inducing stimuli promote VSMC proliferation, leading to vascular remodeling.In contrast, rapamycin-based drugs are used to treat arterial stenosis 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“Indeed, autophagy is a critical determinant of VSMC plasticity and phenotypic switching.”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“Defective autophagy has therefore been implicated in the pathogenesis of several vascular diseases 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“While physiological autophagy promotes VSMC survival, impaired or excessive autophagy may lead to cell death, neointimal formation and atherosclerotic plaque instability 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363
Vascular smooth muscle cells in atherosclerosis
Bennett, M. R., Sinha, S., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306361 · Cited by 2,179
Self-citationCellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Autophagy in cell death: an innocent convict?
Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694
Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
Grootaert, M. O. J., & Bennett, M. R. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab046 · Cited by 531
Self-citationLu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 391
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 363
Petsophonsakul, P., Furmanik, M., Forsythe, R. O., Dweck, M. R., Schurink, G. W. H., Natour, E., Reutelingsperger, C. P. M., Jacobs, M. J. H. M., Mees, B., & Schurgers, L. J. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 357
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis
Grootaert, M. O. J., Finigan, A. J., Figg, N. L., Uryga, A., & Bennett, M. R. (2020) · Circulation Research · doi:10.1161/circresaha.120.318353 · Cited by 252
Self-citationProgrammed cell death in atherosclerosis and vascular calcification
Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243
Li, X., Chen, M., Chen, X., He, X., Li, X., Wei, H., Tan, Y., Min, J., Azam, T., Xue, M., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae379 · Cited by 220
Mechanisms of Arterial Stiffening
Lacolley, P. J., Regnault, V., & Laurent, S. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313129 · Cited by 203
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
Wang, C., Li, Z., Liu, Y., & Yuan, L. (2021) · Theranostics · doi:10.7150/thno.56035 · Cited by 194
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence
Salazar, G., Cullen, A. E., Huang, J., Zhao, Y., Serino, A., Hilenski, L. L., Patrushev, N. A., Forouzandeh, F., & Hwang, H. S. (2019) · Autophagy · doi:10.1080/15548627.2019.1659612 · Cited by 186
Cellular Senescence in Cardiovascular Diseases: A Systematic Review
Hu, C., Zhang, X., Teng, T., Ma, Z., & Tang, Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.0927 · Cited by 184
Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27
Shan, R., Liu, N., Yan, Y., & Liu, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105169 · Cited by 169
New insight into dyslipidemia‐induced cellular senescence in atherosclerosis
Xiang, Q., Tian, F., Xu, J. R., Du, X., Zhang, S., & Liu, L. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12866 · Cited by 169
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Sun, Y., Wang, X., Liu, T., Zhu, X., & Pan, X. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00815-5 · Cited by 156
Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Mubeen, B., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Al-Abbasi, F. A., & Kazmi, I. A. (2022) · Antioxidants · doi:10.3390/antiox11020232 · Cited by 148
Cellular senescence links aging and diabetes in cardiovascular disease
Shakeri, H., Lemmens, K., Gevaert, A. B., De Meyer, G. R. Y., & Segers, V. F. M. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00287.2018 · Cited by 134
FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia
Liu, R., Xu, C., Zhang, W., Cao, Y., Ye, J., Li, B., Shi, J., Weng, L., Liu, Y., Liu, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05091-2 · Cited by 136
Guo, M., Yan, R., Ji, Q., Yao, H., Sun, M., Duan, L., Xue, Z., & Jia, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106800 · Cited by 121
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 119
Vascular calcification: Molecular mechanisms and therapeutic interventions
Pan, W. D., Jie, W., & Huang, H. (2023) · MedComm · doi:10.1002/mco2.200 · Cited by 121
MicroRNA-34a: the bad guy in age-related vascular diseases
Raucci, A., Macrì, F., Castiglione, S., Badi, I., Vinci, M. C., & Zuccolo, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03979-4 · Cited by 118
Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Zhang, Y., Whaley‐Connell, A. T., Sowers, J. R., & Ren, J. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.004 · Cited by 109
Peng, S., Xu, L., Che, X., Xiao, Q., Pu, J., Shao, Q., & He, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00438 · Cited by 107
Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification
Bartoli‐Leonard, F., Wilkinson, F. L., Schiro, A., Serracino‐Inglott, F., Alexander, M. Y., & Weston, R. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa134 · Cited by 109
The Effects of Porphyromonas gingivalis on Atherosclerosis-Related Cells
Zhang, J., Xie, M., Huang, X., Chen, G., Yin, Y., Lu, X., Feng, G., Yu, R., & Chen, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766560 · Cited by 108
Protective role of chaperone-mediated autophagy against atherosclerosis
Madrigal-Matute, J., de Bruijn, J., van Kuijk, K., Riascos-Bernal, D. F., Diaz, A., Tasset, I., Martín-Segura, A., Gijbels, M. J. J., Sander, B., Kaushik, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121133119 · Cited by 107
PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing
Jia, Y., Mao, C., Ma, Z., Huang, J., Li, W., Ma, X., Zhang, S., Li, M., Yu, F., Sun, Y., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.321005 · Cited by 103
The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Samarakoon, R., Higgins, S. P., Higgins, C. E., & Higgins, P. J. (2019) · Biomolecules · doi:10.3390/biom9080341 · Cited by 104
Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity
Hu, D., Yin, C., Luo, S., Habenicht, A. J. R., & Mohanta, S. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01101 · Cited by 102
Macrophage Subsets and Death Are Responsible for Atherosclerotic Plaque Formation
Li, H., Cao, Z., Wang, L., Liu, C., Lin, H., Tang, Y., & Yao, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843712 · Cited by 107
ADAMTS proteases in cardiovascular physiology and disease
Santamaria, S., & de Groot, R. (2020) · Open Biology · doi:10.1098/rsob.200333 · Cited by 98
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
Tai, S., Sun, J., Zhou, Y., Zhu, Z., He, Y., Chen, M., Yang, H., Xiao, Y., Tu, T., Tang, L., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.009 · Cited by 99
Nyúl‐Tóth, Á., Patai, R., Csiszár, A., Ungvari, A., Gulej, R., Mukli, P., Yabluchanskiy, A., Benyó, Z., Sótonyi, P., Prodan, C. I., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01194-0 · Cited by 91
Autophagy at the interface of endothelial cell homeostasis and vascular disease
Mameli, E., Martello, A., & Caporali, A. (2021) · FEBS Journal · doi:10.1111/febs.15873 · Cited by 88
Multiple functions of autophagy in vascular calcification
Zhou, X., Xu, S., Yuan, S.-T., Lei, X., Sun, X., Xing, L., Li, H.-J., He, C., Qin, W. D., Zhao, D., et al. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00639-9 · Cited by 90
Liu, D., Yang, K., Gu, H., Li, Z., Wang, Y., & Wang, Y. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01704-4 · Cited by 88
Li, Y. E., Sowers, J. R., Hetz, C. A., & Ren, J. T. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04942-2 · Cited by 90
Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis
Zhi, W., Liu, Y., Wang, X., & Zhang, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115749 · Cited by 85
Wen, J., Sun, H., Yang, B. V., Song, E., & Song, Y. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133583 · Cited by 85
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects
Picos, A., Seoane, N., Campos‐Toimil, M., & Viña, D. (2025) · Biogerontology · doi:10.1007/s10522-025-10256-5 · Cited by 84
The emerging role of cell senescence in atherosclerosis
Wu, C.-M., Zheng, L., Wang, Q., & Hu, Y. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0601 · Cited by 80
Khavinson, V., Linkova, N. S., Dyatlova, A., Кантемирова, Р. К., & Kozlov, K. L. (2022) · Cells · doi:10.3390/cells12010106 · Cited by 80
Inflammation and hypertension: Underlying mechanisms and emerging understandings
Aboukhater, D., Morad, B., Nasrallah, N., Nasser, S. A., Sahebkar, A., Kobeissy, F. H., Boudaka, A., & Eid, A. H. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31019 · Cited by 78
Bartoli‐Leonard, F., Wilkinson, F. L., Schiro, A., Serracino‐Inglott, F., Alexander, M. Y., & Weston, R. (2019) · Scientific Reports · doi:10.1038/s41598-018-37027-2 · Cited by 76
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Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 81
Chen, Z., Ouyang, C., Zhang, H., Gu, Y., Deng, Y., Du, C., Cui, C., Li, S., Wang, W., Kong, W., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2026097 · Cited by 75
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Alonso-Herranz, L., Albarrán-Juárez, J., & Bentzon, J. F. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1254114 · Cited by 72
Csiszár, A., Ungvari, A., Patai, R., Gulej, R., Yabluchanskiy, A., Benyó, Z., Kovács, I., Sótonyi, P., Kirkpartrick, A. C., Prodan, C. I., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01139-7 · Cited by 75
Therapeutic angiogenesis-based strategy for peripheral artery disease
Han, J., Luo, L., Marcelina, O., Kasim, V., & Wu, S. (2022) · Theranostics · doi:10.7150/thno.74785 · Cited by 77
Lipid-lowering in diabetes: An update
Chait, A., Eckel, R. H., Vrablı́k, M., & Zambon, A. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117313 · Cited by 71
Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis
Jinson, S., Zhang, Z., Lancaster, G. I., Murphy, A. J., & Morgan, P. K. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae270 · Cited by 74
Effects of diosgenin and its derivatives on atherosclerosis
Wu, F.-C., & Jiang, J. (2019) · Food & Function · doi:10.1039/c9fo00749k · Cited by 69
Nahapetyan, H., Moulis, M., Grousset, E., Faccini, J., Grazide, M.-H., Mucher, E., Elbaz, M., Martinet, W., & Vindis, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1400-0 · Cited by 70
Self-citationZhao, X., Tan, F., Cao, X., Cao, Z., Li, B., Shen, Z., & Tian, Y. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz135 · Cited by 70
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Machado-Oliveira, G., Ramos, C., Marques, A. R. A., & Vieira, O. V. (2020) · Cells · doi:10.3390/cells9102146 · Cited by 70
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Zhang, Y., Weng, J., Huan, L., Sheng, S., & Xu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1165507 · Cited by 67
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Talepoor, A. G., & Doroudchi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945016 · Cited by 65
Wu, L., Sowers, J. R., Zhang, Y., & Ren, J. T. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac080 · Cited by 65
Ma, S., Motevalli, S. M., Chen, J., Xu, M., Wang, Y., Feng, J. H., Qiu, Y. F., Han, D., Fan, M., Ding, M., et al. (2018) · Theranostics · doi:10.7150/thno.24364 · Cited by 63
Exosomes: Multifaceted Messengers in Atherosclerosis
Wang, H., Xie, Y., Salvador, A. M., Zhang, Z., Chen, K., Li, G., & Junjie, X. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00871-7 · Cited by 62
Bochaton‐Piallat, M., & Bäck, M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy031 · Cited by 62
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Bohr, D. F. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-632310-8.x5000-1 · Cited by 59
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dos Passos, R. R., dos Santos, C. V., Priviero, F. B. M., Briones, A. M., Tostes, R. C., Webb, R. C., & Bomfim, G. F. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.21712 · Cited by 59
Oikonomou, E. K., West, H. W., & Antoniades, C. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312899 · Cited by 58
Zhao, N., Yu, X., Zhu, X., Song, Y., Gao, F., Yu, B., & Qu, A. (2023) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-023-10470-x · Cited by 59
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Zha, Y., Zhuang, W., Yang, Y., Zhou, Y., Li, H., & Liang, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.910580 · Cited by 55
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Chen, T.-Q., Hu, N., Huo, B., Masau, J. F., Yi, X., Zhong, X., Chen, Y., Guo, X., Zhu, X., Xiang, W., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.38835 · Cited by 54
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Peng, R., Ji, H., Jin, L., Lin, S., Huang, Y., Xu, K., Yang, Q., Sun, D., & Wu, W. (2020) · Journal of Immunology Research · doi:10.1155/2020/8131754 · Cited by 53
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Han, J., Luo, L., Wang, Y., Wu, S., & Kasim, V. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.974775 · Cited by 54
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Song, Z., Wei, D., Chen, Y., Chen, L., Bian, Y., Shen, Y., Chen, J., & Pan, Y. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.002 · Cited by 51
Zhuo, X., Wu, Y., Yang, Y., Gao, L. T., Qiao, X., & Chen, T. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116696 · Cited by 51
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Chen, X., Yu, W., Zhang, J., Fan, X., Liu, X., Liu, Q., Pan, S., Dixon, R. A. F., Li, P., Yu, P., et al. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00330-2 · Cited by 50
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Wang, G., Luo, Y., Gao, X., Yu, L., Yang, F., Wu, J., Fang, D., & Luo, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04793-w · Cited by 51
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He, H., Law, B. Y. K., Zhang, N., Qiu, C., Qu, Y. Q., Wu, A., Han, Y. K., Song, Q., Zheng, W., Liu, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01427 · Cited by 49
Wang, L., Lie, D., Lin, N., Shi, Y., Chen, J., Zhou, Y., Chen, D., Liu, S., & Li, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118253 · Cited by 48
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Lin, J., Wang, X., Gu, M., Chen, Y., Xu, J., Chau, N. V., Li, J., Ji, X., Chu, Q., Qing, L., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155617 · Cited by 47
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Zhu, H., Wang, Z., Dong, Z., Wang, C., Cao, Q., Fan, F., Zhao, J., Liu, X., Yuan, M., Sun, X., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.033 · Cited by 46
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Azar, P., Jarr, K.-U., Gomez, D. A., Jørgensen, H. F., Leeper, N. J., & Bochaton‐Piallat, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf337 · Cited by 45
Metadata
- Authors
- Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y.
- Affiliations
- University of Cambridge (GB)
- Inserm (FR)
- University of Antwerp (BE)
- Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-18
- Volume
- 114
- Issue
- 4
- Pages
- 622-634
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2792785502
- Cited by
- 606
- References
- 95
- Citations by year
- 2026: 57 · 2025: 80 · 2024: 108 · 2023: 73 · 2022: 112 · 2021: 70 · 2020: 54 · 2019: 32 · 2018: 19
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- FWO (G.0412.16 N)
- British Heart Foundation (RG/13/14/30314 and PG/16/11/32021)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- vascular smooth muscle cells, atherosclerosis, apoptosis, autophagy, cellular senescence, stress-induced premature senescence, replicative senescence, plaque stability, fibrous cap thinning, necrotic core, calcification, oxidized LDL, nitric oxide, inflammatory cytokines, autophagy modulators, VSMC phenotypic switching
- MeSH terms
- Animals, Arteries, Autophagy, Humans, Muscle, Smooth, Vascular, Phenotype, Signal Transduction, Cellular Senescence, Myocytes, Smooth Muscle, Cell Proliferation, Atherosclerosis, Plaque, Atherosclerotic
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