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Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis
Open accessAbstract
In the present review, we describe the causes and consequences of loss of vascular smooth muscle cells (VSMCs) or their function in advanced atherosclerotic plaques and discuss possible mechanisms such as cell death or senescence, and induction of autophagy to promote cell survival. We also highlight the potential use of pharmacological modulators of these processes to limit plaque progression and/or improve plaque stability. VSMCs play a pivotal role in atherogenesis. Loss of VSMCs via initiation of cell death leads to fibrous cap thinning and promotes necrotic core formation and calcification. VSMC apoptosis is induced by pro-inflammatory cytokines, oxidized low density lipoprotein, high levels of nitric oxide and mechanical injury. Apoptotic VSMCs are characterized by a thickened basal lamina surrounding the cytoplasmic remnants of the VSMC. Inefficient clearance of apoptotic VSMCs results in secondary necrosis and subsequent inflammation. A critical determinant in the VSMC stress response and phenotypic switching is autophagy, which is activated by various stimuli, including reactive oxygen and lipid species, cytokines, growth factors and metabolic stress. Successful autophagy stimulates VSMC survival, whereas reduced autophagy promotes age-related changes in the vasculature. Recently, an interesting link between autophagy and VSMC senescence has been uncovered. Defective VSMC autophagy accelerates not only the development of stress-induced premature senescence but also atherogenesis, albeit without worsening plaque stability. VSMC senescence in atherosclerosis is likely a result of replicative senescence and/or stress-induced premature senescence in response to DNA damaging and/or oxidative stress-inducing stimuli. The finding that VSMC senescence can promote atherosclerosis further illustrates that normal, adequate VSMC function is crucial in protecting the vessel wall against atherosclerosis.
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“Furthermore, targeting autophagy demonstrates bidirectional therapeutic potential in vascular pathologies.While autophagy induction may protect against endothelial dysfunction and hypertension, autophagy-inducing stimuli promote VSMC proliferation, leading to vascular remodeling.In contrast, rapamycin-based drugs are used to treat arterial stenosis 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“Indeed, autophagy is a critical determinant of VSMC plasticity and phenotypic switching.”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“Defective autophagy has therefore been implicated in the pathogenesis of several vascular diseases 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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“While physiological autophagy promotes VSMC survival, impaired or excessive autophagy may lead to cell death, neointimal formation and atherosclerotic plaque instability 5 .”
From Targeting autophagy to treat neointimal hyperplasia in vascular disease (2025) · cites this paper as [5]
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Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363
Vascular smooth muscle cells in atherosclerosis
Bennett, M. R., Sinha, S., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306361 · Cited by 2,179
Self-citationCellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Autophagy in cell death: an innocent convict?
Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694
Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491
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The Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis
Hua, Y., Zhang, J., Liu, Q., Su, J., Zhao, Y., Zheng, G., Yang, Z., Zhuo, D., Ma, C., & Fan, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.831847 · Cited by 45
Clement, M., Raffort, J., Lareyre, F., Tsiantoulas, D., Newland, S., Lu, Y., Masters, L., Harrison, J., Saveljeva, S., Ma, M. K. L., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315248 · Cited by 44
Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells
Hu, M., Jia, F., Huang, W., Xu, L. L., Hu, D., Wang, J., Ren, K., Fu, G., Wang, Y., & Ji, J. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.013 · Cited by 44
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis
Liu, S., Jiang, X., Cui, X., Wang, J., Liu, S., Li, H., Yang, J., Zhang, C., & Zhang, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03671-2 · Cited by 43
Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead
Sun, L. J., Zhang, W., Zhao, Y., Wang, F., Liu, S., Liu, L., Zhao, L., Lu, W., Li, M., & Xu, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01456 · Cited by 43
Cao, J., Chen, C., Chen, Q., Gao, Y., Zhao, Z., Yuan, Q., Li, A., Yang, S., He, Y., Zu, X., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03502-8 · Cited by 43
Age-Related Lysosomal Dysfunctions
Guerrero‐Navarro, L., Jansen‐Dürr, P., & Cavinato, M. S. (2022) · Cells · doi:10.3390/cells11121977 · Cited by 44
Han, J., Park, H.-S., Lee, D., Jo, J.-H., Heo, K., & Myung, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118978 · Cited by 42
Necroptosis in atherosclerosis
Zhang, X., Ren, Z., Xu, W., & Jiang, Z. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.07.004 · Cited by 42
Jiang, T., Ruan, N., Luo, P., Wang, Q., Wei, X., Li, Y., Dai, Y., Li, L., Lv, J., Liu, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102320 · Cited by 43
Wortmann, M., Skorubskaya, E., Peters, A. S., Hakimi, M., Böckler, D., & Dihlmann, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.051 · Cited by 41
Liu, Y., Song, A., Wu, H., Sun, Y., & Dai, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118714 · Cited by 41
The Effect of Blood Pressure Variability on Coronary Atherosclerosis Plaques
Liu, Y., Luo, X., Jia, H., & Yu, B. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.803810 · Cited by 40
Jarad, S., Gill, G. S., Amadi, P. U., Gu, H.-M., & Zhang, D. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107833 · Cited by 40
Biological Activities of Paeonol in Cardiovascular Diseases: A Review
Vellasamy, S., Murugan, D. D., Abas, R., Alias, A., Wu, Y. S., & Choy, K. W. (2021) · Molecules · doi:10.3390/molecules26164976 · Cited by 39
The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment
Dabravolski, S. A., Sukhorukov, V. N., Melnichenko, A. А., Khotina, V. A., & Orekhov, A. N. (2023) · Biomedicines · doi:10.3390/biomedicines11072010 · Cited by 39
Komaravolu, R. K., Waltmann, M. D., Konaniah, E. S., Jaeschke, A., & Hui, D. Y. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313194 · Cited by 38
Zhang, J., & Sun, H. (2020) · Hypertension Research · doi:10.1038/s41440-020-00553-6 · Cited by 38
Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
Prilepskii, A. Y., Serov, N., Kladko, D. V., & Vinogradov, V. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111056 · Cited by 38
The emerging role of pyroptosis-related inflammasome pathway in atherosclerosis
Xu, X., Chen, J., Zhu, L., Xu, S., Jiang, J., & Ren, K. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00594-2 · Cited by 40
Li, X., Yang, Y., Wang, Z., Lin, X., Fu, X., He, X., Liu, M., Wang, J., Yu, T., & Sun, P. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.011 · Cited by 38
Liu, Q., Wang, Y., & Gu, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.10.025 · Cited by 38
Chronic Stress A Potential Suspect Zero of Atherosclerosis: A Systematic Review
Meng, L., Zhang, Y.-M., Luo, Y., Gong, T., & Liu, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.738654 · Cited by 38
Kong, N., Xu, Q. L., Cui, W., Feng, X., & Gao, H. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-4652 · Cited by 37
Lu, M., Lei, Z., Pan, J., Shi, H., Zhang, M., & Li, C. (2023) · Food & Function · doi:10.1039/d3fo01688a · Cited by 36
Cardiac Computed Tomography Radiomics for the Non-Invasive Assessment of Coronary Inflammation
Cheng, K., Lin, A., Yuvaraj, J., Nicholls, S. J., & Wong, D. T. L. (2021) · Cells · doi:10.3390/cells10040879 · Cited by 36
Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease
López‐Baltanás, R., Rodríguez-Ortiz, M. E., Canalejo, A., Díaz‐Tocados, J. M., Herencia, C., Leiva‐Cepas, F., Torres-Peña, J. D., Ortiz-Morales, A. M., Muñoz-Castañeda, J. R., Rodríguez, M., et al. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13561 · Cited by 36
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Rao, Z., Zheng, Y., Xu, L., Wang, Z., Zhou, Y., Chen, M., Dong, N., Cai, Z., & Li, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.918056 · Cited by 36
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Li, H., Zhang, J., Tan, M., Yin, Y., Song, Y., Zhao, Y., Lin, Y., Li, N., Zhang, X., Bai, J., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122544 · Cited by 36
Bing, T. K., Xiang, S., Jisheng, W., Jie, H., Cao, R., Zhiwei, Z., Yu, B., Zhao-xin, M., Hu, Z., & Zhou, N. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00887-8 · Cited by 35
Młynarska, E., Kowalik, A., Krajewska, A., Krupińska, N., Marcinkowska, W., Motor, J., Przybylak, A., Tłustochowicz, K., Rysz, J., & Franczyk, B. (2025) · Biomolecules · doi:10.3390/biom15101452 · Cited by 36
Carracedo, J., Alique, M., Ramírez-Carracedo, R., Bodega, G., & Ramı́rez, R. (2018) · Current Vascular Pharmacology · doi:10.2174/1570161116666180820115726 · Cited by 35
Wang, H., Wei, Z., Li, H., Guan, Y., Han, Z., Wang, H., & Liu, B. (2020) · Bioscience Reports · doi:10.1042/bsr20193425 · Cited by 35
Endolysosomal Ca2+ signaling in cardiovascular health and disease
Negri, S., Faris, P. S., & Moccia, F. D. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.03.001 · Cited by 36
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Checkouri, É., Blanchard, V., & Meilhac, O. (2021) · Biomedicines · doi:10.3390/biomedicines9091214 · Cited by 39
Luo, H., Li, Y., Song, H., Zhao, K., Li, W., Hong, H., Wang, Y., Qi, L., & Zhang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1416992 · Cited by 35
Klimentova, E. A., Suchkov, I. A., Egorov, A. A., & Kalinin, R. E. (2020) · Современные технологии в медицине · doi:10.17691/stm2020.12.4.13 · Cited by 34
Ali, I., Zhang, H., Zaidi, S. A. A., & Zhou, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102273 · Cited by 36
Yu, W., Ilyas, I., Hu, X., Xu, S., & Yu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1072007 · Cited by 34
Han, Z., Hu, H., Yin, M., Yu, L., Yan, Y., Han, P., Liu, B., & Jing, B. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00685-8 · Cited by 34
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Ungvari, Z. I., Fekete, M., Varga, P., Fekete, J. T., Buda, A., Szappanos, Á., Lehoczki, A., Mózes, N., Grosso, G., Menyhárt, O., et al. (2025) · GeroScience · doi:10.1007/s11357-024-01491-8 · Cited by 35
Bai, H., Lu, Z., Zhao, J., Ma, X., Li, X.-H., Xu, H., Wu, S.-G., Kang, C., Lu, J., Xu, Y., et al. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00077.2019 · Cited by 33
Zhang, G., He, C., Wu, Q., Xu, G., Kuang, M., Wang, T., Xu, L., Zhou, H., & Yuan, W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6662225 · Cited by 33
Tang, Y., Jiao, Y., An, X., Tu, Q., & Jiang, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117476 · Cited by 32
Lee, J., Yoo, J. H., Kim, H. S., Cho, Y. K., Lee, Y. L., Lee, W. J., Park, J., & Jung, C. H. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111114 · Cited by 32
Efferocytosis of vascular cells in cardiovascular disease
Cabrera, J. T. O., & Makino, A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107919 · Cited by 32
Wang, Y., Dou, W., Qian, X., Chen, H., Zhang, Y., Yang, L., Wu, Y., & Xu, X. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123528 · Cited by 33
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Xu, C., Qiu, Z., Guo, Q., Huang, Y., Zhao, Y., & Zhao, R. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02720-5 · Cited by 34
Zhou, W. P., Ye, S., & Wang, W. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i4.466 · Cited by 31
Sheng, S., Xu, J., Liang, Q., Hong, L., & Zhang, L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6241242 · Cited by 31
Wu, Q., Li, D., Huang, C., Zhang, G., Wang, Z., Liu, J., Yu, H., Song, B., Zhang, N., Li, B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113517 · Cited by 32
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Gil-Hernández, A., & Silva‐Palacios, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101193 · Cited by 30
Wang, T., Ding, J., Cheng, X., Yang, Q., & Hu, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396656 · Cited by 29
Sutanto, H., Fetarayani, D., Narendra, M. R., & Nasution, S. A. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.106488 · Cited by 30
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Wang, S., Yuan, R., Liu, M., Zhang, Y., Jia, B., Ruan, J., Shen, J., Zhang, Y., Liu, M., & Wang, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113712 · Cited by 29
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Deng, Y., Adam, V., Nepovimová, E., Heger, Z., Valko, M., Wu, Q., Wei, W., & Kuča, K. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03540-1 · Cited by 29
Gu, J., Chen, J., Yin, Q., Dong, M., Zhang, Y., Chen, M., Chen, X., Min, J., He, X., Tan, Y., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.319250 · Cited by 28
Epigenetic regulation of vascular smooth muscle cell phenotypes in atherosclerosis
Lambert, J., & Jørgensen, H. F. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119085 · Cited by 28
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Bartolo, A. D., Angelone, T., & Rocca, C. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107462 · Cited by 30
Pu, Y., Zhou, Y., Guo, T., Pan, X., Sun, X., Yang, G., & Chai, X. (2025) · The FASEB Journal · doi:10.1096/fj.202501761r · Cited by 28
Sun, Y., Zhao, J., Chi, B., & Wang, K. (2020) · Cell Biology International · doi:10.1002/cbin.11365 · Cited by 28
Wang, C., Dai, S., Gong, L., Fu, K., Ma, C., Liu, Y., Zhou, H., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.791214 · Cited by 28
Wang, Y., Zhang, C., Ge, S., & Gong, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4624 · Cited by 28
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Cell senescence: basic mechanisms and the need for computational networks in vascular ageing
Regnault, V., Challande, P., Pinet, F., Li, Z., & Lacolley, P. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa318 · Cited by 27
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
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Bai, X., Wang, Y., Luo, X., Bao, X., Weng, X., Chen, Y., Zhang, S., Lv, Y., Dai, X., Zeng, M. Y., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01480-6 · Cited by 27
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Guo, M.-Y., Cai, Y., He, C., & Li, Z. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-02173-1 · Cited by 26
Wang, G., Zhu, Y., Li, K., Liao, B., Wang, F., Shao, L., Huang, L., & Bai, D. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001069 · Cited by 26
He, Y., Yi, X., Zhang, Z., Luo, H., Li, R., Feng, X., Fang, Z., Zhu, X., Cheng, W., Jiang, D., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01321-8 · Cited by 26
Shao, S., Liu, Y., Hong, W., Mo, Y., Shu, F., Jiang, L., & Tan, N. (2023) · Biomedicines · doi:10.3390/biomedicines11020635 · Cited by 26
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Liu, S., Xu, D., Ma, J., Huang, P., Wu, D., & Ren, L.-Q. (2021) · Inflammation · doi:10.1007/s10753-021-01511-1 · Cited by 25
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Li, H., Xu, J., Zhang, Y., Hong, L., He, Z., Zeng, Z., & Zhang, L. (2022) · Human Cell · doi:10.1007/s13577-022-00758-6 · Cited by 25
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Kim, S. G., Sung, J. Y., Kang, Y. J., & Choi, H. C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115892 · Cited by 27
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Gao, R., Shi, J., Lyu, Y., Ren, B., Wei, W., Cheng, J., Chen, J., Zhou, Y., Chen, J., Sun, X., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322508 · Cited by 24
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Wang, S., Li, P., Jiang, G., Guan, J., Chen, D., & Zhang, X. (2020) · Bioengineered · doi:10.1080/21655979.2020.1788354 · Cited by 24
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Csiki, D. M., Ababneh, H., Tóth, A., Lente, G., Szöőr, Á., Tóth, A., Fillér, C., Juhász, T., Nagy, B., Balogh, E., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1168339 · Cited by 25
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He, J., Gao, Y., Yang, C., Guo, Y., Liu, L., Lu, S., & He, H. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.047 · Cited by 24
Sung, J. Y., Kim, S. G., Park, S., Kim, J., & Choi, H. C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01297-w · Cited by 25
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Yan, J., Gao, B., Wang, C., Lu, W., Qin, W., Han, X., Liu, Y., Li, T., Guo, Z., Ye, T., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12425 · Cited by 23
Pelisek, J., Reutersberg, B., Greber, U. F., & Zimmermann, A. (2022) · Clinical Science · doi:10.1042/cs20220235 · Cited by 23
Zhang, W., Wang, L., Wang, Y., Fang, Y., Cao, R., Fang, Z., Han, D. G., Huang, X., Gu, Z., Zhang, Y., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2602-7 · Cited by 22
Metadata
- Authors
- Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y.
- Affiliations
- University of Cambridge (GB)
- Inserm (FR)
- University of Antwerp (BE)
- Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-18
- Volume
- 114
- Issue
- 4
- Pages
- 622-634
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2792785502
- Cited by
- 606
- References
- 95
- Citations by year
- 2026: 57 · 2025: 80 · 2024: 108 · 2023: 73 · 2022: 112 · 2021: 70 · 2020: 54 · 2019: 32 · 2018: 19
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- FWO (G.0412.16 N)
- British Heart Foundation (RG/13/14/30314 and PG/16/11/32021)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- vascular smooth muscle cells, atherosclerosis, apoptosis, autophagy, cellular senescence, stress-induced premature senescence, replicative senescence, plaque stability, fibrous cap thinning, necrotic core, calcification, oxidized LDL, nitric oxide, inflammatory cytokines, autophagy modulators, VSMC phenotypic switching
- MeSH terms
- Animals, Arteries, Autophagy, Humans, Muscle, Smooth, Vascular, Phenotype, Signal Transduction, Cellular Senescence, Myocytes, Smooth Muscle, Cell Proliferation, Atherosclerosis, Plaque, Atherosclerotic
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