Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction

Mougenot, Nathalie; Mika, Delphine; Czibik, Gabor; Marcos, Elizabeth; Abid, Shariq; Houssaini, Amal; Vallin, Benjamin; Guellich, Aziz; Mehel, Hind; Sawaki, Daigo; Vandecasteele, Grégoire; Fischmeister, Rodolphe; Hajjar, Roger J; Dubois-Randé, Jean-Luc; Limon, Isabelle; Adnot, Serge; Derumeaux, Geneviève; Lipskaia, Larissa

doi:10.1093/cvr/cvy306

Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction

Aims Increase of cardiac cAMP bioavailability and PKA activity through adenylyl-cyclase 8 (AC8) overexpression enhances contractile function in young transgenic mice (AC8TG). Ageing is associated with decline of cardiac contraction partly by the desensitization of β-adrenergic/cAMP signalling. Ou…