Hajjar, Roger J.

Apoptosis in Myocytes in End-Stage Heart Failure

Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine

Cell death mechanisms and regulationCardiac Fibrosis and Remodeling

Cited by 1,430

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca 2+ -ATPase in Patients With Advanced Heart Failure

Jessup, M., Greenberg, B., Mancini, D., Cappola, T., Pauly, D. F., Jaski, B., Yaroshinsky, A., Zsebo, K. M., Dittrich, H., & Hajjar, R. J. (2011) · Circulation

Virus-based gene therapy researchHeart Failure Treatment and Management

Cited by 760

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy

Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine

Pluripotent Stem Cells ResearchCardiomyopathy and Myosin Studies

Cited by 696

Restoration of Contractile Function in Isolated Cardiomyocytes From Failing Human Hearts by Gene Transfer of SERCA2a

del Monte, F., Harding, S. E., Schmidt, U., Matsui, T., Kang, Z. B., Dec, G. W., Gwathmey, J. K., Rosenzweig, A., & Hajjar, R. J. (1999) · Circulation

Cardiac electrophysiology and arrhythmiasCardiomyopathy and Myosin Studies

Cited by 502

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

Jaski, B. E., Jessup, M. L., Mancini, D. M., Cappola, T. P., Pauly, D. F., Greenberg, B., Borow, K., Dittrich, H., Zsebo, K. M., & Hajjar, R. J. (2009) · Journal of Cardiac Failure

Virus-based gene therapy researchHeart Failure Treatment and Management

Cited by 457

Functional consequences of caspase activation in cardiac myocytes

Communal, C., Sumandea, M., de Tombe, P., Narula, J., Solaro, R. J., & Hajjar, R. J. (2002) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationCardiomyopathy and Myosin Studies

Cited by 390

Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca 2+ -ATPase in a Rat Model of Heart Failure

del Monte, F., Williams, E., Lebeche, D., Schmidt, U., Rosenzweig, A., Gwathmey, J. K., Lewandowski, E. D., & Hajjar, R. J. (2001) · Circulation

Cardiac electrophysiology and arrhythmiasVirus-based gene therapy research

Cited by 382

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

Louis Jeune, V., Joergensen, J. A., Hajjar, R. J., & Weber, T. (2013) · Human Gene Therapy Methods

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 358

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

Makarenko, I., Opitz, C. A., Leake, M. C., Neagoe, C., Kulke, M., Gwathmey, J. K., del Monte, F., Hajjar, R. J., & Linke, W. A. (2004) · Circulation Research

Cardiomyopathy and Myosin StudiesCardiac Fibrosis and Remodeling

Cited by 332

Long-Term Effects of AAV1/SERCA2a Gene Transfer in Patients With Severe Heart Failure: Analysis of Recurrent Cardiovascular Events and Mortality

Zsebo, K., Yaroshinsky, A., Rudy, J. J., Wagner, K., Greenberg, B., Jessup, M., & Hajjar, R. J. (2014) · Circulation Research

Virus-based gene therapy researchCardiac electrophysiology and arrhythmias

Cited by 315

Restoration of Diastolic Function in Senescent Rat Hearts Through Adenoviral Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase

Schmidt, U., del Monte, F., Miyamoto, M. I., Matsui, T., Gwathmey, J. K., Rosenzweig, A., & Hajjar, R. J. (2000) · Circulation

Cardiac electrophysiology and arrhythmiasCardiovascular Function and Risk Factors

Cited by 230

Altered Myocardial Calcium Cycling and Energetics in Heart Failure—A Rational Approach for Disease Treatment

Gorski, P. A., Ceholski, D. K., & Hajjar, R. J. (2015) · Cell Metabolism

Cardiac electrophysiology and arrhythmiasCardiovascular Function and Risk Factors

Cited by 213

Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

Byrne, M. J., Power, J. M., Preovolos, A., Mariani, J. A., Hajjar, R. J., & Kaye, D. M. (2008) · Gene Therapy

Virus-based gene therapy researchCardiac electrophysiology and arrhythmias

Cited by 184

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 184

Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models

Rapti, K., Louis-Jeune, V., Kohlbrenner, E., Ishikawa, K., Ladage, D., Zolotukhin, S., Hajjar, R. J., & Weber, T. (2012) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 170

Gene therapy for the treatment of heart failure: promise postponed

Hulot, J.-S., Ishikawa, K., & Hajjar, R. J. (2016) · European Heart Journal

Virus-based gene therapy researchHeart Failure Treatment and Management

Cited by 150

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Chen, A., Lieu, D. K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., et al. (2011) · Advanced Materials

Cellular Mechanics and InteractionsAdvanced Materials and Mechanics

Cited by 122

Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy.

Lebeche, D., Davidoff, A. J., & Hajjar, R. J. (2008) · Nature Clinical Practice Cardiovascular Medicine

Cardiovascular Function and Risk FactorsCardiac electrophysiology and arrhythmias

Cited by 122

Effect of Intracoronary Administration of AAV1/SERCA2a on Ventricular Remodelling in Patients with Advanced Systolic Heart Failure: Results from the Agent-Hf Randomized Phase 2 Trial

Hulot, J.-S., Salem, J.-E., Redheuil, A., Collet, J.-P., Varnous, S., Jourdain, P., Logeart, D., Gandjbakhch, E., Bernard, C., Hatem, S. N., et al. (2017) · European Journal of Heart Failure

Virus-based gene therapy researchCardiac Fibrosis and Remodeling

Cited by 113

A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells

Weng, Z., Kong, C.-W., Ren, L., Karakikes, I., Geng, L., He, J., Chow, M. Z. Y., Mok, C. F., Chan, H. Y. S., Webb, S. E., et al. (2014) · Stem Cells and Development

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 109

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Stillitano, F., Turnbull, I. C., Karakikes, I., Nonnenmacher, M., Backeris, P., Hulot, J.-S., Kranias, E. G., Hajjar, R. J., & Costa, K. D. (2016) · European Heart Journal

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 77

Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation

Beeri, R., Chaput, M., Guerrero, J. L., Kawase, Y., Yosefy, C., Abedat, S., Karakikes, I., Morel, C., Tisosky, A., Sullivan, S., et al. (2010) · Circulation: Heart Failure

Cardiac Fibrosis and RemodelingCardiac Structural Anomalies and Repair

Cited by 69

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias

Wang, J., Chen, A., Lieu, D. K., Karakikes, I., Chen, G., Keung, W., Chan, C. W., Hajjar, R. J., Costa, K. D., Khine, M., et al. (2013) · Biomaterials

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

Cited by 69

SERCA2a in Heart Failure: Role and Therapeutic Prospects

Gianni, D., Chan, J., Gwathmey, J. K., del Monte, F., & Hajjar, R. J. (2005) · Journal of Bioenergetics and Biomembranes

Cardiac electrophysiology and arrhythmiasCardiomyopathy and Myosin Studies

Cited by 65