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Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging

Open access
Lakatta, Edward G.·2003·Circulation
DOI 10.1161/01.cir.0000048894.99865.02
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Abstract

E vidence supporting the hypothesis that age-associated changes in cardiovascular structure/function are implicated in the markedly increased risk for cardiovascular disease in older persons has been presented in the preceding 2 articles in this series.1,2 It follows that therapies to prevent or delay cardiovascular changes that accompany aging may reduce the risk for age-associated cardiovascular diseases.Understanding the nature and effectiveness of such therapies, however, requires an understanding of heart and arterial aging at the cellular and molecular levels.Fortunately, many of the age-associated changes in cardiac and arterial structure or function that have been observed in humans also occur across a wide range of other species.Insights gained from cellular and molecular studies in these animal models may hold clues that will assist in directing future efforts toward developing novel therapies for age-associated arterial and cardiac structural and functional remodeling in humans. Vascular AgingAge-associated remodeling of the walls of large arteries of rodents (Table 1) and nonhuman primates is quite similar to that observed in humans and includes luminal dilation, intimal and medial thickening (Figure 1), vascular stiffening, and endothelial dysfunction.3-

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Metadata

Authors
Lakatta, E. G.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-01-28
Volume
107
Issue
3
Pages
490-497
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000048894.99865.02
OpenAlex
W2149136975
Cited by
1,084
References
12
FWCI
27.87
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging. https://app.cochat.ai/papers/10.1161/01.cir.0000048894.99865.02
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Lakatta, E. G. (2003). Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging. Circulation. https://doi.org/10.1161/01.cir.0000048894.99865.02

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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