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Cited by 281

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

The Human Intestinal Microbiome: A New Frontier of Human Biology

Open access
Hattori, M., Taylor, T. D.·2009·DNA Research

Abstract

To analyze the vast number and variety of microorganisms inhabiting the human intestine, emerging metagenomic technologies are extremely powerful. The intestinal microbes are taxonomically complex and constitute an ecologically dynamic community (microbiota) that has long been believed to possess a strong impact on human physiology. Furthermore, they are heavily involved in the maturation and proliferation of human intestinal cells, helping to maintain their homeostasis and can be causative of various diseases, such as inflammatory bowel disease and obesity. A simplified animal model system has provided the mechanistic basis for the molecular interactions that occur at the interface between such microbes and host intestinal epithelia. Through metagenomic analysis, it is now possible to comprehensively explore the genetic nature of the intestinal microbiome, the mutually interacting system comprising the host cells and the residing microbial community. The human microbiome project was recently launched as an international collaborative research effort to further promote this newly developing field and to pave the way to a new frontier of human biology, which will provide new strategies for the maintenance of human health.

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Metadata

Authors
Hattori, M., & Taylor, T. D.
Venue
DNA Research
Published
2009-01-08
Volume
16
Issue
1
Pages
1-12
ISSN
  • 1340-2838 (ISSN-L)
  • 1756-1663
OpenAlex
W2125755185
Cited by
281
References
31
FWCI
11.04
Type
journal article
Language
en
Open access
gold

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Hattori, M., & Taylor, T. D. (2009). The Human Intestinal Microbiome: A New Frontier of Human Biology. DNA Research. https://doi.org/10.1093/dnares/dsn033

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