First report of myocarditis in two patients with COVID-19 Omicron variant: case report
Open accessAbstract
Background: Severe acute respiratory syndrome coronavirus 2 infection is responsible for the coronavirus disease 2019 (COVID-19) pandemics. Omicron (B.1.1.529) variant is the cause for the surge of the COVID-19 pandemics of the end of 2021 and the beginning of 2022, although its subvariants are responsible for the following daily increase of COVID-19 cases in July 2022. Early reports of Omicron variant confirmed patients indicated less severe disease course compared with the disease caused by previously encountered variants with absence of data regarding cardiac involvement by Omicron. Case summary: A 42-year-old male who tested positive for Omicron was admitted on January 2022 with chest pain and ST-segment elevation in the inferior leads. Coronary angiography revealed non-significant coronary artery disease. Cardiac magnetic resonance imaging demonstrated features consistent with myocarditis with involvement of 22% of the left ventricular mass by late gadolinium enhancement involving both the lateral and the septal walls. The second patient is a 60-year-old male presented following syncope and palpitations after he was confirmed with Omicron infection. Upon emergency department arrival he had ventricular tachycardia of 250 beats/minute and underwent urgent cardioversion. During his hospitalization, there was no recurrence of malignant arrhythmia, coronary angiography revealed non-obstructive disease. Cardiac magnetic resonance imaging demonstrated imaging features suggesting acute myocarditis with involvement of 19% of the left ventricular mass. Discussion: This is the first report of myocarditis cases as a possible complication associated with Omicron variant. Despite preliminary reports of less severe disease clinicians should be vigilant for potential deleterious cardiac complications of Omicron.
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Soon after the Omicron variant emerged, case reports of myocarditis appeared.
“Soon after the Omicron variant emerged, case reports of myocarditis appeared.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [109]
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2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344 · see citing works
Characteristics of SARS-CoV-2 and COVID-19
Hu, B., Guo, H., Zhou, P., & Shi, Z.-L. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00459-7 · Cited by 5,291 · see citing works
Wolter, N., Jassat, W., Walaza, S., Welch, R., Moultrie, H., Groome, M., Amoako, D. G., Everatt, J., Bhiman, J. N., Scheepers, C., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00017-4 · Cited by 1,041 · see citing works
Ammirati, E., Frigerio, M., Adler, E. D., Basso, C., Birnie, D. H., Brambatti, M., Friedrich, M. G., Klingel, K., Lehtonen, J., Moslehi, J. J., et al. (2020) · Circulation: Heart Failure · doi:10.1161/circheartfailure.120.007405 · Cited by 811 · see citing works
Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection
Lala, A., Johnson, K. W., Januzzi, J. L., Russak, A. J., Paranjpe, I., Richter, F., Zhao, S., Somani, S., Van Vleck, T., Vaid, A., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.06.007 · Cited by 791 · see citing works
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
Witberg, G., Barda, N., Hoss, S., Richter, I., Wiessman, M., Aviv, Y., Grinberg, T., Auster, O., Dagan, N., Balicer, R. D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110737 · Cited by 613 · see citing works
Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
Hachmann, N. P., Miller, J. J., Collier, A.-R. Y., Ventura, J. D., Yu, J., Rowe, M., Bondzie, E. A., Powers, O. C., Surve, N., Hall, K., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmc2206576 · Cited by 530 · see citing works
Daniels, C. J., Rajpal, S., Greenshields, J. T., Rosenthal, G. L., Chung, E. H., Terrin, M. C., Jeudy, J. J., Mattson, S. E., Law, I. H., Borchers, J. R., et al. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.2065 · Cited by 325 · see citing works
Winter of Omicron—The Evolving COVID-19 Pandemic
del Rı́o, C., Omer, S. B., & Malani, P. (2021) · JAMA · doi:10.1001/jama.2021.24315 · Cited by 213 · see citing works
Dyer, O. (2021) · BMJ · doi:10.1136/bmj.n3104 · Cited by 102 · see citing works
Kleynhans, J., Tempia, S., Wolter, N., von Gottberg, A., Bhiman, J. N., Buys, A., Moyes, J., McMorrow, M. L., Kahn, K., Gómez-Olivé, F. X., et al. (2021) · Emerging Infectious Diseases · doi:10.3201/eid2712.211465 · Cited by 97 · see citing works
Mahase, E. (2021) · BMJ · doi:10.1136/bmj.n3151 · Cited by 75 · see citing works
Adverse Effects after BNT162b2 Vaccine and SARS-CoV-2 Infection, According to Age and Sex
Dagan, N., Barda, N., & Balicer, R. D. (2021) · New England Journal of Medicine · doi:10.1056/nejmc2115045 · Cited by 47 · see citing works
COVID-19 fulminant myocarditis: a case report
Torres, W. B., Escandón, Á. H., Hurtado-Rivera, M., & Plata-Mosquera, C. A. (2020) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytaa212 · Cited by 37 · see citing works
Papageorgiou, J., Almroth, H., Törnudd, M., van der Wal, H., Varelogianni, G., & Lawesson, S. S. (2020) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytaa523 · Cited by 22 · see citing works
Cardiac Involvement in COVID-19 Patients: A Contemporary Review
Carretta, D. M., Silva, A. M., D’Agostino, D., Topi, S., Lovero, R., Charitos, I. A., Wegierska, A. E., Montagnani, M., & Santacroce, L. (2021) · Infectious Disease Reports · doi:10.3390/idr13020048 · Cited by 21 · see citing works
Khaloo, P., Shaqdan, A. W., Ledesma, P. A., Uzomah, U. A., Galvin, J., Ptaszek, L. M., & Ruskin, J. N. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.12.029 · Cited by 14 · see citing works
Fiore, G., Sanvito, F., Fragasso, G., & Spoladore, R. (2021) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytab357 · Cited by 11 · see citing works
Flagged first, then by citations
2 of the 20 references couldn’t be matched to a known paper.
Cited by
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COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works
Frasca, L., Ocone, G., & Palazzo, R. (2023) · Pathogens · doi:10.3390/pathogens12020233 · Cited by 15 · see citing works
Chen, R., Guo, Y., Deng, S., Wang, J., Gao, M., Han, H., Wang, L., Jiang, H., & Huang, K. (2023) · Cardiology Plus · doi:10.1097/cp9.0000000000000049 · Cited by 12 · see citing works
Comparison of COVID-19 Vaccine-Associated Myocarditis and Viral Myocarditis Pathology
Hamedi, K. R., Loftus, G., Traylor, L. B., Goodwin, R. L., & Arce, S. (2023) · Vaccines · doi:10.3390/vaccines11020362 · Cited by 13 · see citing works
Dorajoo, S. R., Tan, H. X., Teo, C. H. D., Neo, J. W., Koon, Y. L., Ng, J. J. A., Tham, M. Y., Foo, P. Q. B., Peck, L. F., Ang, P. S., et al. (2023) · Vaccine X · doi:10.1016/j.jvacx.2023.100419 · Cited by 10 · see citing works
Prostaglandin E2 and myocarditis; friend or foe?
Bryson, T. D., & Harding, P. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115813 · Cited by 7 · see citing works
The Eye of the Storm: Investigating the Long-Term Cardiovascular Effects of COVID-19 and Variants
Vishwakarma, N., Goud, R. B., Tirupattur, M. P., & Katwa, L. C. (2023) · Cells · doi:10.3390/cells12172154 · Cited by 6 · see citing works
Tham, M. Y., Chan, C. L., Toh, D., Poh, J. W. W., Lim, A., Soh, S. B. L., Peck, L. F., Foo, B., Ng, A., Ng, P., et al. (2024) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2023-089 · Cited by 4 · see citing works
Roser, L., Samanapally, H., Ali, T., Xu, Q., Han, Y., Salunkhe, V., Deepti, F., McGuffin, T., Huang, E. C., Furmanek, S. P., et al. (2024) · Frontiers in Epidemiology · doi:10.3389/fepid.2024.1342917 · Cited by 4 · see citing works
Coronavirus Disease 2019, Myocardial Injury, and Myocarditis
Xiang, L., Zhang, L., Zhang, T., Zhang, H., Guo, C., Liu, S., Wang, Q., Cai, H., & Lu, Z. (2023) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2023.0025 · Cited by 2 · see citing works
Prognostic value of echocardiogram and cardiac biomarkers through three waves of COVID-19
Han, Y., Long, G. A., Ali, T., Deitz, K., Samanapally, H., Salunkhe, V., Deepti, F., Huang, E. C., Sunkara, J., Cermack, K., et al. (2025) · Journal of Anesthesia and Translational Medicine · doi:10.1016/j.jatmed.2025.05.002
Waksman, O., Abusnina, W. A., Case, B. C., Cellamare, M., Zhang, C., Rappaport, H., Sawant, V., THAKKAR, Y., & Waksman, R. (2026) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.70659
- Authors
- Fishman, B., Goitein, O., Berkovitch, A., Rahav, G., & Matetzky, S.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Fishman, Boris
- Venue
- European Heart Journal - Case Reports
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-10-01
- Volume
- 6
- Issue
- 10
- Pages
- ytac407-ytac407
- ISSN
- 2514-2119 (ISSN-L)
- PMC
- PMC9581207
- OpenAlex
- W4301585726
- Cited by
- 12
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 8
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- European Heart Journal - Case Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- myocarditis, COVID-19 pandemic, Omicron variant, cardiac complications of COVID-19, ventricular tachycardia, syncope, ST-segment elevation, late gadolinium enhancement, cardiac magnetic resonance imaging, non-obstructive coronary artery disease
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