The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Finding nuclear localization signals
Open accessAbstract
A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated ‘ in silico mutagenesis’ we then extended the set to 214 potential NLSs. This final set matched in 43% of all known nuclear proteins and in no known non‐nuclear protein. We estimated that >17% of all eukaryotic proteins may be imported into the nucleus. Finally, we found an overlap between the NLS and DNA‐binding region for 90% of the proteins for which both the NLS and DNA‐binding regions were known. Thus, evolution seemed to have used part of the existing DNA‐binding mechanism when compartmentalizing DNA‐binding proteins into the nucleus. However, only 56 of our 214 NLS motifs overlapped with DNA‐binding regions. These 56 NLSs enabled a de novo prediction of partial DNA‐binding regions for ∼800 proteins in human, fly, worm and yeast.
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Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
Chen, L., Glover, J. N. M., Hogan, P. G., Rao, A., & Harrison, S. C. (1998) · Nature · doi:10.1038/32100 · Cited by 521 · cited 1×
“Zoom into the interface between DNA and P55-C-fos proto-oncogene protein [note, the other parts of the amazing crystal structure of the complex with PDB code 1a02 (Chen et al., 1998) are not shown].”
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Cited by
Rost, B., Yachdav, G., & Liu, J. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh377 · Cited by 1,453
Self-citationPlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors
Jin, J., Zhang, H., Kong, L., Gao, G., & Luo, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1016 · Cited by 963
Analysis and prediction of leucine-rich nuclear export signals
la Cour, T., Kiemer, L., Mølgaard, A., Gupta, R., Skriver, K., & Brunak, S. (2004) · Protein Engineering, Design and Selection · doi:10.1093/protein/gzh062 · Cited by 759
Reich, N. C., & Liu, L. (2006) · Nature Reviews Immunology · doi:10.1038/nri1885 · Cited by 376
Jäkel, S., Mingot, J.-M., Schwarzmaier, P., Hartmann, E., & Görlich, D. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.377 · Cited by 323
Metadata
- Authors
- Cokol, M., Nair, R., & Rost, B.
- Venue
- EMBO reports
- Published
- 2000-11
- Volume
- 1
- Issue
- 5
- Pages
- 411-415
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2137601093
- Cited by
- 692
- References
- 1
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- green
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