Tracking STAT nuclear traffic
Abstract
Accurate cellular localization is crucial for the effective function of most signalling molecules and nuclear translocation is central to the function of transcription factors. The passage of large molecules between the cytoplasm and nucleus is restricted, and this restriction affords a mechanism to regulate transcription by controlling the access of transcription factors to the nucleus. In this Review, we focus on the signal transducer and activator of transcription (STAT) family of transcription factors. The regulation of the nuclear trafficking of STAT-family members is diverse. Some STAT proteins constitutively shuttle between the nucleus and cytoplasm, whereas others require tyrosine phosphorylation for nuclear localization. In either case, the regulation of nuclear trafficking can provide a target for therapeutic intervention.
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In unstimulated cells, mKate2-STAT3 is equally distributed between cytoplasm and nucleus (nuc/cyt ratio 1).
“In unstimulated cells, mKate2-STAT3 was equally distributed between cytoplasm and nucleus (STAT3 nuc/cyt ratio of 1), in accordance with the previously reported continuous shuttling of STAT3 independent of its activation state (Liu et al., 2005; Reich and Liu, 2006).”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Reich and Liu, 2006
STAT3 continuously shuttles between cytoplasm and nucleus independent of its activation state.
“STAT3 was shown to continuously shuttle between cytoplasm and nucleus independent of its activation state (Liu et al., 2005; Reich and Liu, 2006).”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Reich and Liu, 2006
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“Nuclear STAT3 independent of phosphorylation STAT3 was first identified as a DNA-binding factor that is activated by IL-6 to regulate gene expression in the acute-phase inflammatory respons”
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The JAK/STAT Pathway in Model Organisms
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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
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The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
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“In unstimulated cells, mKate2-STAT3 was equally distributed between cytoplasm and nucleus (STAT3 nuc/cyt ratio of 1), in accordance with the previously reported continuous shuttling of STAT3 independent of its activation state (Liu et al., 2005; Reich and Liu, 2006).”
Background
- Authors
- Reich, N. C., & Liu, L.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Reich, Nancy C.
- Venue
- Nature Reviews Immunology
- Published
- 2006-08
- Volume
- 6
- Issue
- 8
- Pages
- 602-612
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2078841246
- Cited by
- 376
- References
- 5
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 8 · 2023: 11 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 10 · 2018: 16 · 2017: 18 · 2016: 15 · 2015: 15 · 2014: 23 · 2013: 44 · 2012: 22
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- STAT proteins, nuclear trafficking, nuclear translocation, transcription factors, tyrosine phosphorylation, transcriptional regulation, therapeutic target
- MeSH terms
- Animals, Cell Nucleus, DNA, Humans, Active Transport, Cell Nucleus, STAT Transcription Factors, STAT3 Transcription Factor, STAT5 Transcription Factor, Interferon-Stimulated Gene Factor 3, gamma Subunit
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