The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression
Open accessAbstract
The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation, were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo , we inactivated the murine SNF5/INI1 gene, a common subunit of these two complexes. Mice lacking SNF5 protein stop developing at the peri‐implantation stage, showing that the SWI/SNF complex is essential for early development and viability of early embryonic cells. Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild‐type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types.
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Cites
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Cited by
Chromatin remodelling during development
Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114
Chromatin modifiers and remodellers: regulators of cellular differentiation
Chen, T., & Dent, S. Y. R. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3607 · Cited by 619
From neural development to cognition: unexpected roles for chromatin
Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544
Lund, A. H., & van Lohuizen, M. (2004) · Genes & Development · doi:10.1101/gad.1232504 · Cited by 489
Marked for death: Targeting epigenetic changes in cancer
Pfister, S. X., & Ashworth, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.256 · Cited by 288
Metadata
- Authors
- Klochendler‐Yeivin, A., Fiette, L., Barra, J., Muchardt, C., Babinet, C., & Yaniv, M.
- Venue
- EMBO reports
- Published
- 2000-12
- Volume
- 1
- Issue
- 6
- Pages
- 500-506
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2126087647
- Cited by
- 406
- References
- 1
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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