The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Chromatin modifiers and remodellers: regulators of cellular differentiation
Abstract
Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelling during differentiation, which results in a progressive transition from a fairly open chromatin configuration to a more compact state. Genetic studies in mouse models show major roles for a variety of histone modifiers and chromatin remodellers in key developmental transitions, such as the segregation of embryonic and extra-embryonic lineages in blastocyst stage embryos, the formation of the three germ layers during gastrulation and the differentiation of adult stem cells. Furthermore, rather than merely stabilizing the gene expression changes that are driven by developmental transcription factors, there is emerging evidence that chromatin regulators have multifaceted roles in cell fate decisions.
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“Epigenetic modifiers have fundamental roles in defining unique cellular identity through the establishment and maintenance of lineage-specific chromatin and methylation status1”
From Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 (2015) · cites this paper as [1]
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Yamamizu, K., Fujihara, M., Tachibana, M., Katayama, S., Takahashi, A., Hara, E., Imai, H., Shinkai, Y., & Yamashita, J. K. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.022 · Cited by 36
RetractedA bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Human DNA methylomes at base resolution show widespread epigenomic differences
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
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Cancer epigenetics: from mechanism to therapy
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DNA methylation: roles in mammalian development
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Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Polycomb complexes repress developmental regulators in murine embryonic stem cells
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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
Establishing neural crest identity: a gene regulatory recipe
Simões-Costa, M., & Bronner, M. E. (2015) · Development · doi:10.1242/dev.105445 · Cited by 649
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy
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Metadata
- Authors
- Chen, T., & Dent, S. Y. R.
- Venue
- Nature Reviews Genetics
- Published
- 2013-12-24
- Volume
- 15
- Issue
- 2
- Pages
- 93-106
- ISSN
- 1471-0056
- 1471-0064
- PMC
- PMC3999985
- Cited by
- 619
- References
- 141
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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