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Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N‐WASP‐defective cells
Open accessAbstract
In mammalian cells, actin dynamics is tightly controlled through small GTPases of the Rho family, WASP/Scar proteins and the Arp2/3 complex. We employed Cre/ loxP ‐mediated gene targeting to disrupt the ubiquitously expressed N‐WASP in the mouse germline, which led to embryonic lethality. To elucidate the role of N‐WASP at the cellular level, we immortalized embryonic fibroblasts and selected various N‐WASP‐defective cell lines. These fibroblasts showed no apparent morphological alterations and were highly responsive to the induction of filopodia, but failed to support the motility of Shigella flexneri . In addition, enteropathogenic Escherichia coli were incapable of inducing the formation of actin pedestals in N‐WASP‐defective cells. Our results prove the essential role of this protein for actin cytoskeletal changes induced by these bacterial pathogens in vivo and in addition show for the first time that N‐WASP is dispensible for filopodia formation.
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Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Takenawa, T., & Miki, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1801 · Cited by 604
Cited by
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton.
Takenawa, T., & Suetsugu, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2069 · Cited by 947
Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration
Le Clainche, C., & Carlier, M.-F. (2008) · Physiological Reviews · doi:10.1152/physrev.00021.2007 · Cited by 849
Cellular Control of Actin Nucleation
Welch, M. D., & Mullins, R. D. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.040202.112133 · Cited by 517
Campellone, K. G., Robbins, D., & Leong, J. M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.004 · Cited by 311
Regulation of actin dynamics by WASP and WAVE family proteins
Stradal, T. E. B., Rottner, K., Disanza, A., Confalonieri, S., Innocenti, M., & Scita, G. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.04.007 · Cited by 286
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Metadata
- Authors
- Lommel, S., Benesch, S., Rottner, K., Franz, T., Wehland, J., & Kühn, R.
- Venue
- EMBO reports
- Published
- 2001-09
- Volume
- 2
- Issue
- 9
- Pages
- 850-857
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2020422209
- Cited by
- 259
- References
- 2
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N‐WASP‐defective cells. https://app.cochat.ai/papers/10.1093/embo-reports/kve197
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- Lommel, S., Benesch, S., Rottner, K., Franz, T., Wehland, J., & Kühn, R. (2001). Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N‐WASP‐defective cells. EMBO reports. https://doi.org/10.1093/embo-reports/kve197
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