Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues

Swerdlow, S. H. (2017) · Medical Entomology and Zoology · Cited by 12,933 · see citing works

DNA methylation in cancer: too much, but also too little

Ehrlich, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205651 · Cited by 1,540 · see citing works

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083557 · Cited by 1,401 · see citing works

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

Delhase, M., Hayakawa, M., Chen, Y., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.309 · Cited by 852 · see citing works

The regulated retrotransposon transcriptome of mammalian cells

Faulkner, G. J., Kimura, Y., Daub, C. O., Wani, S., Plessy, C., Irvine, K. M., Schroder, K., Cloonan, N., Steptoe, A. L., Lassmann, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.368 · Cited by 819 · see citing works

CSF-1 regulation of the wandering macrophage: complexity in action

Pixley, F. J., & Stanley, E. R. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.016 · Cited by 807 · see citing works

The biology of Hodgkin's lymphoma

Küppers, R. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2542 · Cited by 694 · see citing works

Effects of Retroviruses on Host Genome Function

Jern, P., & Coffin, J. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091501 · Cited by 499 · see citing works

Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF‐κB

Mathas, S., Hinz, M., Anagnostopoulos, I., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta‐Grigoriou, F., Stein, H., Dörken, B., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf389 · Cited by 375 · see citing works

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

Howard, G., Eiges, R., Gaudet, F., Jaenisch, R., & Eden, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210631 · Cited by 341 · see citing works

Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone

Feldman, A. L., Arber, D. A., Pittaluga, S., Martı́nez, A., Burke, J. S., Raffeld, M. A., Camós, M., Warnke, R. A., & Jaffe, E. S. (2008) · Blood · doi:10.1182/blood-2007-11-124792 · Cited by 333 · see citing works

Types of dietary fat and breast cancer: A pooled analysis of cohort studies

Smith‐Warner, S. A., Spiegelman, D. L., Adami, H., Beeson, W. L., van den Brandt, P. A., Folsom, A. R., Fraser, G. E., Freudenheim, J. L., Goldbohm, R. A., Graham, S., et al. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20010601)92:5 · Cited by 279 · see citing works

Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling

Küppers, R., Klein, U., Schwering, I., Distler, V., Bräuninger, A., Cattoretti, G., Tu, Y., Stolovitzky, G. A., Califano, A., Hansmann, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16624 · Cited by 242 · see citing works

The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

Gamou, T., Kitamura, E., Hosoda, F., Shimizu, K., Shinohara, K., Hayashi, Y., Nagase, T., Yokoyama, Y., & Ohki, M. (1998) · Blood · doi:10.1182/blood.v91.11.4028 · Cited by 238 · see citing works

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2

Joos, S., Menz, C. K., Wrobel, G., Siebert, R., Gesk, S., Ohl, S., Mechtersheimer, G., Trümper, L. H. P., Mӧller, P., Lichter, P., et al. (2002) · Blood · doi:10.1182/blood.v99.4.1381 · Cited by 236 · see citing works

Identification of a new, abundant superfamily of mammalian LTR-transposons

Smit, A. F. A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.8.1863 · Cited by 235 · see citing works

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert‐Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., et al. (2005) · Nature Immunology · doi:10.1038/ni1285 · Cited by 179 · see citing works

Endogenous retroviruses

Maksakova, I. A., Mager, D. L., & Reiss, D. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8494-3 · Cited by 172 · see citing works

CSF-1 and Its Receptor in Ovarian, Endometrial and Breast Cancer

Kacinski, B. M. (1995) · Annals of Medicine · doi:10.3109/07853899509031941 · Cited by 161 · see citing works

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis

Goardon, N., Lambert, J. A., Rodriguez, P., Nissaire, P., Herblot, S., Thibault, P., Dumènil, D., Strouboulis, J., Roméo, P., & Hoang, T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600934 · Cited by 152 · see citing works

Lsh, an epigenetic guardian of repetitive elements

Huang, J. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh821 · Cited by 139 · see citing works

Acute leukemias of ambiguous lineage

Béné, M. C., & Porwit‐MacDonald, A. (2012) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2011.08.004 · Cited by 139 · see citing works

Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1.

Chambers, S. K., Kacinski, B. M., Ivins, C. M., & Carcangiu, M. L. (1997) · PubMed · Cited by 139 · see citing works

ETO interacting proteins

Hug, B. A., & Lazar, M. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207674 · Cited by 112 · see citing works

Macrophage Colony-Stimulating Factor-1 Receptor Expression Is Associated with Poor Outcome in Breast Cancer by Large Cohort Tissue Microarray Analysis

Kluger, H. M., Dolled-Filhart, M. P., Rodov, S., Kacinski, B. M., Camp, R. L., & Rimm, D. L. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0699-3 · Cited by 110 · see citing works

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma

Mathas, S., Kreher, S., Meaburn, K. J., Jöhrens, K., Lamprecht, B., Assaf, C., Sterry, W., Kadin, M. E., Daibata, M., Joos, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900912106 · Cited by 102 · see citing works

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease

Jundt, F., Kley, K., Anagnostopoulos, I., Pröbsting, K. S., Greiner, A., Mathas, S., Scheidereit, C., Wirth, T. C., Stein, H., & Dörken, B. (2002) · Blood · doi:10.1182/blood.v99.8.3060 · Cited by 96 · see citing works

Differential Transcription of Exon 1 of the Human c-fms Gene in Placental Trophoblasts and Monocytes

Visvader, J. E., & Verma, I. M. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.1336 · Cited by 87 · see citing works

Deletion of Mtg16, a Target of t(16;21), Alters Hematopoietic Progenitor Cell Proliferation and Lineage Allocation

Chyla, B., Moreno–Miralles, I., Steapleton, M. A., Thompson, M. A., Bhaskara, S., Engel, M. E., & Hiebert, S. W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00404-08 · Cited by 84 · see citing works

A CSF‐1 receptor kinase inhibitor targets effector functions and inhibits pro‐inflammatory cytokine production from murine macrophage populations

Irvine, K. M., Burns, C. J., Wilks, A. F., Su, S. V., Hume, D. A., & Sweet, M. J. (2006) · The FASEB Journal · doi:10.1096/fj.06-5848fje · Cited by 84 · see citing works

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

Bonifer, C. (2007) · Frontiers in bioscience · doi:10.2741/2700 · Cited by 70 · see citing works

Retrotransposon‐derived elements in the mammalian genome: A potential source of disease

Druker, R., & Whitelaw, E. (2004) · Journal of Inherited Metabolic Disease · doi:10.1023/b:boli.0000031096.81518.66 · Cited by 67 · see citing works

Stem cell–specific epigenetic priming and B cell–specific transcriptional activation at the mouse Cd19 locus

Walter, K., Bonifer, C., & Tagoh, H. (2008) · Blood · doi:10.1182/blood-2008-02-142786 · Cited by 61 · see citing works

Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype

Ehlers, A., Oker, E., Bentink, S., Lenze, D., Stein, H., & Hummel, M. (2008) · Leukemia · doi:10.1038/leu.2008.12 · Cited by 47 · see citing works

CBFA2T3-ZNF652 Corepressor Complex Regulates Transcription of the E-box Gene HEB

Kumar, R., Cheney, K. M., McKirdy, R., Neilsen, P. M., Schulz, R. B., Lee, J., Cohen, J., Booker, G. W., & Callen, D. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709136200 · Cited by 46 · see citing works

DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development

Fan, T., Schmidtmann, A., Xi, S., Briones, V. R., Zhu, H., Suh, H. C., Gooya, J. M., Keller, J. R., Xu, H., Roayaei, J., et al. (2008) · Epigenetics · doi:10.4161/epi.3.3.6252 · Cited by 41 · see citing works

Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci

Follows, G. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg804 · Cited by 18 · see citing works

Reprogramming of B Lymphoid Cells in Human Lymphoma Pathogenesis

Janz, M., Dörken, B., & Mathas, S. (2006) · Cell Cycle · doi:10.4161/cc.5.10.2737 · Cited by 15 · see citing works

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Burns, C. J., Harte, M. F., Bu, X., Fantino, E., Giarrusso, M. A., Joffe, M. E., Kurek, M., Legge, F. S., Razzino, P., Su, S. V., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.073 · Cited by 14 · see citing works

Immunohistochemical detection of cells positive for colony-stimulating factor 1 in lymph nodes from reactive lymphadenitis, and Hodgkin's disease.

Moreau, A., Praloran, V., Berrada, L., Coupey, L., & Gaillard, F. (1992) · PubMed · Cited by 11 · see citing works

Targeting macrophages: therapeutic approaches in cancer

Cassetta, L., & Pollard, J. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.169 · Cited by 2,057 · see citing works

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works

Regulatory activities of transposable elements: from conflicts to benefits

Chuong, E. B., Elde, N. C., & Feschotte, C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,343 · see citing works

Navigating the DNA methylation landscape of cancer

Nishiyama, A., & Nakanishi, M. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.05.002 · Cited by 974 · see citing works

Endogenous viruses: insights into viral evolution and impact on host biology

Feschotte, C., & Gilbert, C. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3199 · Cited by 885 · see citing works

TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets

Jin, Y., Tam, O. H., Paniagua, E., & Hammell, M. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv422 · Cited by 709 · see citing works

Transposable Elements: An Abundant and Natural Source of Regulatory Sequences for Host Genes

Rebollo, R., Romanish, M. T., & Mager, D. L. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155621 · Cited by 576 · see citing works

Transposable elements in cancer

Burns, K. H. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.35 · Cited by 572 · see citing works

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

Karimi, M. M., Goyal, P., Maksakova, I. A., Bilenky, M., Leung, D., Tang, J. X., Shinkai, Y., Mager, D. L., Jones, S., Hirst, M., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.04.004 · Cited by 535 · see citing works

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

the ICGC MMML-Seq Project (2012) · Nature Genetics · doi:10.1038/ng.2469 · Cited by 435 · see citing works

Transposable elements drive widespread expression of oncogenes in human cancers

Jang, H. J., Shah, N. M., Du, A. Y., Dailey, Z. Z., Pehrsson, E. C., Godoy, P. M., Zhang, D., Li, D., Xing, X., Kim, S., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0373-3 · Cited by 395 · see citing works

KRAB zinc finger proteins

Ecco, G., Imbeault, M., & Trono, D. (2017) · Development · doi:10.1242/dev.132605 · Cited by 368 · see citing works

Molecular Pathogenesis of Hodgkin's Lymphoma: Increasing Evidence of the Importance of the Microenvironment

Steidl, C., Connors, J. M., & Gascoyne, R. D. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.8401 · Cited by 374 · see citing works

The Majority of Primate-Specific Regulatory Sequences Are Derived from Transposable Elements

Jacques, P., Jeyakani, J., & Bourque, G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003504 · Cited by 345 · see citing works

Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire

Thompson, P. J., Macfarlan, T. S., & Lorincz, M. C. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.029 · Cited by 301 · see citing works

Hodgkin lymphoma

Küppers, R., Engert, A., & Hansmann, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61245 · Cited by 291 · see citing works

A Brief History of the Status of Transposable Elements: From Junk DNA to Major Players in Evolution

Biémont, C. (2010) · Genetics · doi:10.1534/genetics.110.124180 · Cited by 283 · see citing works

Immune responses to endogenous retroelements: taking the bad with the good

Kassiotis, G., & Stoye, J. P. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.27 · Cited by 261 · see citing works

Molecular biology of Hodgkin lymphoma

Weniger, M. A., & Küppers, R. (2021) · Leukemia · doi:10.1038/s41375-021-01204-6 · Cited by 252 · see citing works

Endogenous retroviral promoter exaptation in human cancer

Babaian, A., & Mager, D. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0080-x · Cited by 246 · see citing works

Mammalian Endogenous Retroviruses

Mager, D. L., & Stoye, J. P. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0009-2014 · Cited by 237 · see citing works

Resurrection of endogenous retroviruses in antibody-deficient mice

Young, G. R., Eksmond, U., Salcedo, R., Alexopoulou, L., Stoye, J. P., & Kassiotis, G. (2012) · Nature · doi:10.1038/nature11599 · Cited by 215 · see citing works

Regional Activation of the Cancer Genome by Long-Range Epigenetic Remodeling

Bert, S. A., Robinson, M. D., Strbenac, D., Statham, A. L., Song, J. Z., Hulf, T., Sutherland, R. L., Coolen, M. W., Stirzaker, C., & Clark, S. J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.11.006 · Cited by 194 · see citing works

HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

Hohn, O., Hanke, K., & Bannert, N. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00246 · Cited by 196 · see citing works

Endogenous Retroviruses and the Development of Cancer

Kassiotis, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302972 · Cited by 190 · see citing works

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retrovirusesPreprint

Wolf, G., Yang, P., Füchtbauer, A., Füchtbauer, E., Silva, A. M., Park, C., Wu, W., Nielsen, A., Pedersen, F., & Macfarlan, T. (2015) · Genes & Development · doi:10.1101/gad.252767.114 · Cited by 168 · see citing works

Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements

Shah, N. M., Jang, H. J., Liang, Y., Maeng, J. H., Tzeng, S.-C., Wu, A., Basri, N. L., Qu, X., Fan, C., Li, A., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01349-3 · Cited by 175 · see citing works

An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences

Ishak, C. A., Marshall, A. E., Passos, D. T., White, C. R., Kim, S. J., Cecchini, M. J., Ferwati, S., MacDonald, W. A., Howlett, C. J., Welch, I. D., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.021 · Cited by 167 · see citing works

DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis

Young, J. M., Whiddon, J. L., Yao, Z., Kasinathan, B., Snider, L. D., Geng, L. N., Balog, J., Tawil, R., van der Maarel, S. M., & Tapscott, S. J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003947 · Cited by 158 · see citing works

Endogenous retroviruses in the origins and treatment of cancer

Jansz, N., & Faulkner, G. J. (2021) · Genome biology · doi:10.1186/s13059-021-02357-4 · Cited by 155 · see citing works

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact

Queirós, A. C., Villamor, N., Clot, G., Martínez‐Trillos, A., Kulis, M., Navarro, A., Penas, E. M. M., Jayne, S., Majid, A., Richter, J., et al. (2014) · Leukemia · doi:10.1038/leu.2014.252 · Cited by 155 · see citing works

Unfixed Endogenous Retroviral Insertions in the Human Population

Marchi, E., Kanapin, A. A., Magiorkinis, G., & Belshaw, R. D. (2014) · Journal of Virology · doi:10.1128/jvi.00919-14 · Cited by 141 · see citing works

Transposable elements as essential elements in the control of gene expression

Gebrie, A. (2023) · Mobile DNA · doi:10.1186/s13100-023-00297-3 · Cited by 146 · see citing works

Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma

Steidl, C., Diepstra, A., Lee, T., Chan, F. C., Farinha, P., Tan, K. L., Telenius, A., Barclay, L., Shah, S. P., Connors, J. M., et al. (2012) · Blood · doi:10.1182/blood-2012-06-439570 · Cited by 137 · see citing works

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Deniz, Ö., Ahmed, M., Todd, C. D., Rio‐Machín, A., Dawson, M. A., & Branco, M. R. (2020) · Nature Communications · doi:10.1038/s41467-020-17206-4 · Cited by 135 · see citing works

Onco-exaptation of an endogenous retroviral LTR drives IRF5 expression in Hodgkin lymphoma

Babaian, A., Romanish, M. T., Gagnier, L., Kuo, L. Y., Karimi, M. M., Steidl, C., & Mager, D. L. (2016) · Oncogene · doi:10.1038/onc.2015.308 · Cited by 121 · see citing works

An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma

von Tresckow, B., Morschhauser, F., Ribrag, V., Topp, M. S., Chien, C., Seetharam, S., Aquino, R., Kotoulek, S., de Boer, C. J., & Engert, A. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1845 · Cited by 120 · see citing works

Symbiosis: Viruses as Intimate Partners

Roossinck, M. J., & Bazán, E. R. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042323 · Cited by 122 · see citing works

Activation of human endogenous retroviruses and its physiological consequences

Dopkins, N., & Nixon, D. F. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00674-z · Cited by 122 · see citing works

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes

Beyer, U., Moll-Rocek, J., Moll, U. M., & Dobbelstein, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016201108 · Cited by 113 · see citing works

Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer

Romanish, M. T., Cohen, C., & Mager, D. L. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.05.005 · Cited by 113 · see citing works

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

Wolf, G., Greenberg, D., & Macfarlan, T. S. (2015) · Mobile DNA · doi:10.1186/s13100-015-0050-8 · Cited by 109 · see citing works

HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors

Bannert, N., Hofmann, H., Block, A., & Höhn, O. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00178 · Cited by 112 · see citing works

Transposable element regulation and expression in cancer

Grundy, E. E., Diab, N., & Chiappinelli, K. B. (2021) · FEBS Journal · doi:10.1111/febs.15722 · Cited by 113 · see citing works

Role of the colony-stimulating factor (CSF)/CSF-1 receptor axis in cancer

Achkova, D. Y., & Maher, J. F. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150245 · Cited by 111 · see citing works

LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assemblyPreprint

Attig, J., Young, G. R., Hosie, L., Perkins, D., Encheva-Yokoya, V., Stoye, J. P., Snijders, A. P., Ternette, N., & Kassiotis, G. (2019) · Genome Research · doi:10.1101/gr.248922.119 · Cited by 110 · see citing works

Retroviruses facilitate the rapid evolution of the mammalian placenta

Chuong, E. B. (2013) · BioEssays · doi:10.1002/bies.201300059 · Cited by 106 · see citing works

Biology of classical Hodgkin lymphoma: implications for prognosis and novel therapies

Mottok, A., & Steidl, C. (2018) · Blood · doi:10.1182/blood-2017-09-772632 · Cited by 106 · see citing works

Transmission, Evolution, and Endogenization: Lessons Learned from Recent Retroviral Invasions

Greenwood, A. D., Ishida, Y., O’Brien, S. P., Roca, A. L., & Eiden, M. V. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00044-17 · Cited by 103 · see citing works

Therapeutic targeting of DNA methylation alterations in cancer

Lee, A. V., Nestler, K. A., & Chiappinelli, K. B. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108640 · Cited by 98 · see citing works

Molecular functions of human endogenous retroviruses in health and disease

Suntsova, M., Garazha, A., Ivanova, A., Kaminsky, D., Zhavoronkov, A. A., & Buzdin, A. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1947-6 · Cited by 99 · see citing works

Mobile elements in the human genome: implications for disease

Sólyom, S., & Kazazian, H. H. (2012) · Genome Medicine · doi:10.1186/gm311 · Cited by 97 · see citing works

The epigenetic alterations of endogenous retroelements in aging

Cardelli, M. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.02.002 · Cited by 91 · see citing works

Anthropoid primate–specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length

Dunn-Fletcher, C., Muglia, L. M., Pavličev, M., Wolf, G., Sun, M., Hu, Y., Huffman, E., Tumukuntala, S., Thiele, K., Mukherjee, A., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006337 · Cited by 93 · see citing works

Genetic lesions of the TRAF 3 and MAP 3K14 genes in classical H odgkin lymphoma

Otto, C., Giefing, M., Massow, A., Vater, I., Gesk, S., Schlesner, M., Richter, J., Klapper, W., Hansmann, M., Siebert, R., et al. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09113.x · Cited by 94 · see citing works

Mutations in 3′-long terminal repeat of HERV-W family in chromosome 7 upregulate syncytin-1 expression in urothelial cell carcinoma of the bladder through interacting with c-Myb

Yu, H., Liu, T., Zhao, Z., Chen, Y., Zeng, J., Liu, S., & Zhu, F. (2013) · Oncogene · doi:10.1038/onc.2013.366 · Cited by 92 · see citing works

Retrotransposons shape species-specific embryonic stem cell gene expression

Robbez‐Masson, L., & Rowe, H. M. (2015) · Retrovirology · doi:10.1186/s12977-015-0173-5 · Cited by 89 · see citing works

CTRL+INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome

Göke, J., & Ng, H. (2016) · EMBO Reports · doi:10.15252/embr.201642743 · Cited by 88 · see citing works

Human endogenous retroviruses role in cancer cell stemness

Matteucci, C., Balestrieri, E., Argaw-Denboba, A., & Vallebona, P. S. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.10.001 · Cited by 88 · see citing works

Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target

Curty, G., Marston, J. L., Rougvie, M. D. M., Leal, F. E., Nixon, D. F., & Soares, M. A. (2020) · Viruses · doi:10.3390/v12070726 · Cited by 85 · see citing works

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis

Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78 · see citing works

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing

Stoll, G., Oda, S., Chong, Z.-S., Yu, M.-M., McLaughlin, S., & Modis, Y. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1901318116 · Cited by 76 · see citing works

Proliferation of Endogenous Retroviruses in the Early Stages of a Host Germ Line Invasion

Ishida, Y., Zhao, K. X., Greenwood, A. D., & Roca, A. L. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu275 · Cited by 81 · see citing works

Transposable elements as tissue-specific enhancers in cancers of endodermal lineage

Karttunen, K., Patel, D., Xia, J., Fei, L., Palin, K., Aaltonen, L., & Sahu, B. (2022) · bioRxiv · doi:10.1038/s41467-023-41081-4 · Cited by 66 · see citing works

Endogenous Retroviruses: With Us and against Us

Meyer, T. J., Rosenkrantz, J. L., Carbone, L., & Chavez, S. L. (2017) · Frontiers in Chemistry · doi:10.3389/fchem.2017.00023 · Cited by 78 · see citing works

Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer

Ishak, C. A., Classon, M., & Carvalho, D. D. D. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.05.008 · Cited by 79 · see citing works

New insights in the biology of Hodgkin lymphoma

Küppers, R. (2012) · Hematology · doi:10.1182/asheducation.v2012.1.328.3798326 · Cited by 79 · see citing works

Expressional activation and functional roles of human endogenous retroviruses in cancers

Zhang, M., Liang, Q., & Zheng, S. S. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2025 · Cited by 79 · see citing works

Human endogenous retroviruses in development and disease

Mao, J., Zhang, Q., & Cong, Y. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.10.037 · Cited by 77 · see citing works

Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer

Kwon, M. J., & Shin, Y. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12020983 · Cited by 77 · see citing works

Analysis of the Expression of Repetitive DNA Elements in Osteosarcoma

Ho, X. D., Nguyen, H. G., Trinh, L. H., Reimann, E., Prans, E., Kõks, G., Maasalu, K., Le, V. Q., Nguyễn, V. H., Le, N. T. N., et al. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00193 · Cited by 76 · see citing works

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma

Lock, F. E., Rebollo, R., Miceli-Royer, K., Gagnier, L., Kuah, S., Babaian, A., Sistiaga-Poveda, M., Lai, C. B., Nemirovsky, O., Serrano, I., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405507111 · Cited by 75 · see citing works

Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer

Kassiotis, G., & Stoye, J. P. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0277 · Cited by 75 · see citing works

Association of Endogenous Retroviruses and Long Terminal Repeats with Human Disorders

Katoh, I., & Kurata, S. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00234 · Cited by 74 · see citing works

Towards targeting transposable elements for cancer therapy

Liang, Y., Qu, X., Shah, N. M., & Wang, T. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-023-00653-8 · Cited by 70 · see citing works

Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival

Venkataraman, G., Song, J. Y., Tzankov, A., Dirnhofer, S., Heinze, G., Kohl, M., Traverse‐Glehen, A., Eberle, F. C., Hanson, J. C., Raffeld, M. A., et al. (2013) · Blood · doi:10.1182/blood-2012-06-439455 · Cited by 71 · see citing works

Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes

Thompson, M. J., Rubbi, L., Dawson, D. W., Donahue, T. R., & Pellegrini, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128814 · Cited by 70 · see citing works

‘There and back again’: revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era

Magiorkinis, G., Belshaw, R. D., & Katzourakis, A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0504 · Cited by 68 · see citing works

Reprogramming: identifying the mechanisms that safeguard cell identity

Brumbaugh, J., Stefano, B. D., & Hochedlinger, K. (2019) · Development · doi:10.1242/dev.182170 · Cited by 64 · see citing works

Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Hu, C. Y., Mohtat, D., Yu, Y., Ko, Y.-A., Shenoy, N. K., Bhattacharya, S., Izquierdo, M. C., Park, A. S. D., Giricz, O., Vallumsetla, N., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0494 · Cited by 68 · see citing works

Effects of short‐term exposure to inhalable particulate matter on DNA methylation of tandem repeats

Guo, L., Byun, H., Zhong, J., Motta, V., Barupal, J. K., Zheng, Y., Chang, D., Zhang, F., McCracken, J. P., Díaz-Artiga, A., et al. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21838 · Cited by 68 · see citing works

Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn

Tabone, O., Mommert, M., Jourdan, C., Cerrato, E., Legrand, M., Lepape, A., Allaouchiche, B., Rimmele, T., Pachot, A., Monneret, G., et al. (2018) · bioRxiv · doi:10.3389/fimmu.2018.03091 · Cited by 68 · see citing works

The Rec protein of HERV‐K(HML‐2) upregulates androgen receptor activity by binding to the human small glutamine‐rich tetratricopeptide repeat protein (hSGT)

Hanke, K., Chudak, C., Kurth, R., & Bannert, N. (2012) · International Journal of Cancer · doi:10.1002/ijc.27693 · Cited by 67 · see citing works

Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma

Gibb, E. A., Warren, R. M., Wilson, G. W., Brown, S. D., Robertson, G., Morin, G. B., & Holt, R. A. (2015) · Genome Medicine · doi:10.1186/s13073-015-0142-6 · Cited by 65 · see citing works

Colony-Stimulating Factor 1 Receptor (CSF1R) Activates AKT/mTOR Signaling and Promotes T-Cell Lymphoma Viability

Murga‐Zamalloa, C., Rolland, D. C. M., Polk, A., Wolfe, A., Dewar, H., Chowdhury, P., Önder, Ö., Dewar, R., Brown, N. A., Bailey, N. G., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1486 · Cited by 65 · see citing works

The histone variant H2A.Bbd is enriched at sites of DNA synthesis

Sansoni, V., Casas-Delucchi, C. S., Rajan, M., Schmidt, A., Bönisch, C., Thomae, A. W., Staege, M. S., Hake, S. B., Cardoso, M. C., & Imhof, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku303 · Cited by 66 · see citing works

Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA

Buzdin, A. A., Prassolov, V., & Garazha, A. (2017) · Frontiers in Chemistry · doi:10.3389/fchem.2017.00035 · Cited by 63 · see citing works

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM 2.5 ) from biomass combustion

Heßelbach, K., Kim, G.-J., Flemming, S., Häupl, T., Bonin, M., Dornhof, R., Günther, S., Merfort, I., & Humar, M. (2017) · Epigenetics · doi:10.1080/15592294.2017.1356555 · Cited by 65 · see citing works

A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors

Lee, J., Chen, T. W., Hsu, C., Yen, Y., Yang, J. C., Cheng, A., Sasaki, S., Chiu, L., Sugihara, M., Ishizuka, T., et al. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00745-z · Cited by 61 · see citing works

Role of Transposable Elements in Gene Regulation in the Human Genome

Ali, A., Han, K., & Liang, P. (2021) · Life · doi:10.3390/life11020118 · Cited by 61 · see citing works

Reactivation of Endogenous Retroelements in Cancer Development and Therapy

Ishak, C. A., & Carvalho, D. D. D. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033525 · Cited by 58 · see citing works

Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Muliaditan, T., Halim, L., Whilding, L. M., Draper, B., Achkova, D. Y., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100457 · Cited by 59 · see citing works

H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing

Maksakova, I., Goyal, P., Bullwinkel, J., Brown, J. P., Bilenky, M., Mager, D., Singh, P. B., & Lorincz, M. (2011) · Epigenetics & Chromatin · doi:10.1186/1756-8935-4-12 · Cited by 52 · see citing works

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

Kreher, S., Bouhlel, M. A., Cauchy, P., Lamprecht, B., Li, S., Grau, M., Hummel, F., Köchert, K., Anagnostopoulos, I., Jöhrens, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406985111 · Cited by 55 · see citing works

Analysis of RNA-Seq Data Using TEtranscripts

Jin, Y., & Hammell, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7710-9_11 · Cited by 53 · see citing works

The role of endogenous retroviruses‐K in human cancer

Salavatiha, Z., Soleimani‐Jelodar, R., & Jalilvand, S. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2142 · Cited by 57 · see citing works

Macrophages predict treatment outcome in Hodgkin's lymphoma

Steidl, C., Farinha, P., & Gascoyne, R. D. (2011) · Haematologica · doi:10.3324/haematol.2010.033316 · Cited by 54 · see citing works

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells

Cirovic, B., Schönheit, J., Kowenz‐Leutz, E., Ivanovska, J., Klement, C., Pronina, N., Bégay, V., & Leutz, A. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.015 · Cited by 54 · see citing works

miR-107 Activates ATR/Chk1 Pathway and Suppress Cervical Cancer Invasion by Targeting MCL1

Zhou, C., Li, G., Zhou, J., Han, N., Liu, Z., & Yin, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111860 · Cited by 53 · see citing works

Detecting Endogenous Retrovirus-Driven Tissue-Specific Gene Transcription

Pavličev, M., Hiratsuka, K., Swaggart, K. A., Dunn, C., & Muglia, L. J. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv049 · Cited by 52 · see citing works

The role of aberrant transcription factor expression and loss of epigenetic control in activating long-terminal-repeats in Hodgkin’s lymphoma

Edginton‐White, B. (2018)

The role of aberrant transcription factor expression and loss of epigenetic control in activating long-terminal-repeats in Hodgkin’s lymphoma \n

Edginton‐White, B. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)

Abstract B269: Effects of blocking aberrantly expressed CSF-1R in Hodgkin lymphoma.

Campion, L. R., DeAngelis, N., Ferrante, C. A., Verona, R. I., Seetharam, S., Manthey, C. L., & Snyder, L. A. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-13-b269

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Edginton‐White, B., Cauchy, P., Assi, S. A., Hartmann, S., Riggs, A. D., Mathas, S., Cockerill, P. N., & Bonifer, C. (2018) · Leukemia · doi:10.1038/s41375-018-0311-x · Cited by 26 · see citing works

Onco-exaptation of an endogenous retroviral LTR drives IRF5 expression in Hodgkin lymphoma

Babaian, A., Romanish, M. T., Gagnier, L., Kuo, L. Y., Karimi, M. M., Steidl, C., & Mager, D. L. (2016) · Oncogene · doi:10.1038/onc.2015.308 · Cited by 121 · see citing works