Human L1 element target‐primed reverse transcription in vitro

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

Origin and evolution of retroelements based upon their reverse transcriptase sequences

Xiong, Y., & Eickbush, T. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07536.x · Cited by 1,374

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

Luan, D. D., Korman, M. H., Jakubczak, J. L., & Eickbush, T. H. (1993) · Cell · doi:10.1016/0092-8674(93)90078-5 · Cited by 1,173

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139

[5] Synthesis of small RNAs using T7 RNA polymerase

Milligan, J. F., & Uhlenbeck, O. C. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(89)80091-6 · Cited by 1,071

High frequency retrotransposition in cultured mammalian cells

Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D., & Kazazian, H. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81998-4 · Cited by 1,022

Human LINE retrotransposons generate processed pseudogenes

Esnault, C., Maestre, J., & Heidmann, T. (2000) · Nature Genetics · doi:10.1038/74184 · Cited by 835

Biology of Mammalian L1 Retrotransposons

Ostertag, E. M., & Kazazian, H. H. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091032 · Cited by 782

Reverse Transcriptase Encoded by a Human Transposable Element

Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D., & Gabriel, A. (1991) · Science · doi:10.1126/science.1722352 · Cited by 774

Human L1 Retrotransposition: cis Preference versus trans Complementation

Wei, W., Gilbert, N., Ooi, S. L., Lawler, J. F., Ostertag, E. M., Kazazian, H. H., Boeke, J. D., & Moran, J. V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1429-1439.2001 · Cited by 637

Diversity through duplication: Whole‐genome sequencing reveals novel gene retrocopies in the human population

Richardson, S. R., Salvador‐Palomeque, C., & Faulkner, G. J. (2014) · BioEssays · doi:10.1002/bies.201300181 · Cited by 38

The carboxy‐terminal segment of the human LINE‐1 ORF2 protein is involved in RNA binding

Piskareva, O., Ernst, C., Higgins, N., & Schmatchenko, V. (2013) · FEBS Open Bio · doi:10.1016/j.fob.2013.09.005 · Cited by 37

Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

Yang, L., Emerman, M., Malik, H. S., & McLaughlin, R. N. (2020) · eLife · doi:10.7554/elife.58436 · Cited by 35

An Increased Burden of Highly Active Retrotransposition Competent L1s Is Associated with Parkinson’s Disease Risk and Progression in the PPMI Cohort

Pfaff, A. L., Bubb, V. J., Quinn, J. P., & Kõks, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186562 · Cited by 37

Condensation of LINE-1 is critical for retrotransposition

Sil, S., Keegan, S., Ettefa, F., Denes, L. T., Boeke, J. D., & Holt, L. J. (2023) · eLife · doi:10.7554/elife.82991 · Cited by 39

Mobility Pathways for Vertebrate L1, L2, CR1, and RTE Clade Retrotransposons

Ichiyanagi, K., & Okada, N. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn061 · Cited by 36

More active human L1 retrotransposons produce longer insertions

Farley, A. H. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh202 · Cited by 36

Expressing genes do not forget their LINEs: transposable elements and gene expression

Kristine, J. K. (2011) · Frontiers in bioscience · doi:10.2741/3990 · Cited by 37

DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes

Knisbacher, B. A., & Levanon, E. Y. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv239 · Cited by 34

The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations

Kines, K. J., Sokolowski, M. J., deHaro, D. L., Christian, C. M., Baddoo, M., Smither, M. E., & Belancio, V. P. (2016) · Mobile DNA · doi:10.1186/s13100-016-0064-x · Cited by 38

Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H

Feng, Y., Goubran, M., Follack, T. B., & Chelico, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-11344-4 · Cited by 35

RNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA

Moldovan, J. B., Wang, Y., Shuman, S., Mills, R. E., & Moran, J. V. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805404116 · Cited by 38

A Comparative Approach Shows Differences in Patterns of Numt Insertion During Hominoid Evolution

Jensen‐Seaman, M. I., Wildschutte, J. H., Soto‐Calderón, I. D., & Anthony, N. M. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9243-4 · Cited by 35

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes

Richardson, S. R., Doucet, A. J., Kopera, H. C., Moldovan, J. B., Garcia-Perez, J. L., & Moran, J. V. (2015) · ASM Press eBooks · doi:10.1128/9781555819217.ch51 · Cited by 38

Densely ionizing radiation affects DNA methylation of selective LINE-1 elements

Prior, S., Miousse, I. R., Nzabarushimana, É., Pathak, R., Skinner, C. M., Kutanzi, K. R., Allen, A. R., Raber, J., Tackett, A. J., Hauer‐Jensen, M., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.06.043 · Cited by 34

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex

Handa, S., Jiang, Y., Tao, S., Foreman, R., Schinazi, R. F., Miller, J. F., & Ghosh, P. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky620 · Cited by 34

What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation

Percharde, M., Sultana, T., & Ramalho‐Santos, M. (2020) · BioEssays · doi:10.1002/bies.201900232 · Cited by 32

RIP-seq reveals LINE-1 ORF1p association with p-body enriched mRNAs

Briggs, E. M., McKerrow, W., Mita, P., Boeke, J. D., Logan, S. K., & Fenyö, D. (2021) · Mobile DNA · doi:10.1186/s13100-021-00233-3 · Cited by 35

Analysis of epigenetic features characteristic of L1 loci expressed in human cells

Freeman, B., White, T., Kaul, T. K., Stow, E. C., Baddoo, M., Ungerleider, N., Morales, M. E., Yang, H., deHaro, D. L., Deininger, P. L., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac013 · Cited by 33

The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

Luqman-Fatah, A., Watanabe, Y., Uno, K., Ishikawa, F., Moran, J. V., & Miyoshi, T. (2023) · Nature Communications · doi:10.1038/s41467-022-35757-6 · Cited by 46

Target Site Recognition by a Diversity-Generating Retroelement

Guo, H., Tse, L. V., Nieh, A. W., Czornyj, E., Williams, S. R., Oukil, S., Liu, V. B., & Miller, J. F. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002414 · Cited by 34

LINE Insertion Polymorphisms are Abundant but at Low Frequencies across Populations of Anolis carolinensis

Ruggiero, R. P., Bourgeois, Y., & Boissinot, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00044 · Cited by 33

Retrotransposition of Long Interspersed Element 1 Induced by Methamphetamine or Cocaine

Okudaira, N., Ishizaka, Y., & Nishio, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559419 · Cited by 30

Different integration site structures between L1 protein-mediated retrotransposition in cis and retrotransposition in trans

Kojima, K. K. (2010) · Mobile DNA · doi:10.1186/1759-8753-1-17 · Cited by 32

The Minimal Active Human SVA Retrotransposon Requires Only the 5′-Hexamer and Alu-Like Domains

Hancks, D. C., Mandal, P. K., Cheung, L. E., & Kazazian, H. H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00860-12 · Cited by 34

Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation

Miousse, I. R., Chang, J., Shao, L., Pathak, R., Nzabarushimana, É., Kutanzi, K. R., Landes, R. D., Tackett, A. J., Hauer‐Jensen, M., Zhou, D., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071430 · Cited by 31

Mechanisms of disease-associated SINE-VNTR-Alus

Pfaff, A. L., Singleton, L. M., & Kõks, S. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221082612 · Cited by 32

Novel retrotransposon analysis reveals multiple mobility pathways dictated by hostsPreprint

Ichiyanagi, K., Nakajima, R., Kajikawa, M., & Okada, N. (2006) · Genome Research · doi:10.1101/gr.5542607 · Cited by 31

The power of “controllers”: Transposon-mediated duplicated genes evolve towards neofunctionalization

Ma, H., Wang, M., Zhang, Y. E., & Tan, S. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.04.003 · Cited by 34

An Alu-Based Phylogeny of Lemurs (Infraorder: Lemuriformes)

McLain, A. T., Meyer, T. J., Faulk, C. D., Herke, S. W., Oldenburg, J. M., Bourgeois, M. G., Abshire, C. F., Roos, C., & Batzer, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044035 · Cited by 31

L1 retrotransposition

Viollet, S., Monot, C., & Cristofari, G. (2014) · Mobile Genetic Elements · doi:10.4161/mge.28907 · Cited by 30

LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq

McKerrow, W., Kagermazova, L., Doudican, N. A., Frazzette, N., Kaparos, E. I., Evans, S. A., Rocha, A. V., Sedivy, J. M., Neretti, N., Carucci, J. A., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad049 · Cited by 31

LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice

Geister, K. A., Brinkmeier, M. L., Cheung, L., Wendt, J., Oatley, M. J., Burgess, D. L., Kozloff, K. M., Cavalcoli, J. D., Oatley, J. M., & Camper, S. A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005569 · Cited by 31

APE-type non-LTR retrotransposons: determinants involved in target site recognition

Zingler, N., Weichenrieder, O., & Schumann, G. G. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084959 · Cited by 31

Retrotransposition and genomic imprinting

Cowley, M., & Oakey, R. J. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq015 · Cited by 29

Secondary structure models of the 3′ untranslated regions of diverse R2 RNAs

Ruschak, A. M., Mathews, D. H., Bibiłło, A., Spinelli, S. L., Childs‐Disney, J. L., Eickbush, T. H., & Turner, D. H. (2004) · RNA · doi:10.1261/rna.5216204 · Cited by 29

Drawing a fine line on endogenous retroelement activity

Castro-Díaz, N., Friedli, M., & Trono, D. (2015) · Mobile Genetic Elements · doi:10.1080/2159256x.2015.1006109 · Cited by 30

Retrotransposons in pluripotent cells: Impact and new roles in cellular plasticity

Macia, Á., Blanco-Jimenez, E., & Garcia-Perez, J. L. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.007 · Cited by 30

Long interspersed nuclear element-1 mobilization as a target in cancer diagnostics, prognostics and therapeutics

Lavasanifar, A., Sharp, C. N., Korte, E. A., Yin, T., Hosseinnejad, K., & Jortani, S. A. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.015 · Cited by 29

DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA

Naorem, S. S., Han, J.-Y., Wang, S., Lee, W. R., Heng, X., Miller, J. F., & Guo, H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715952114 · Cited by 27

Subtype classification and functional annotation of L1Md retrotransposon promoters

Zhou, M., & Smith, A. D. (2019) · Mobile DNA · doi:10.1186/s13100-019-0156-5 · Cited by 25

Skeletal muscle LINE-1 ORF1 mRNA is higher in older humans but decreases with endurance exercise and is negatively associated with higher physical activity

Roberson, P. A., Romero, M. A., Osburn, S. C., Mumford, P. W., Vann, C. G., Fox, C. D., McCullough, D. J., Brown, M. D., & Roberts, M. D. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00352.2019 · Cited by 28

Post-transcriptional regulation of LINE-1 retrotransposition by AID/APOBEC and ADAR deaminases

Orecchini, E., Frassinelli, L., Galardi, S., Ciafrè, S. A., & Michienzi, A. (2018) · Chromosome Research · doi:10.1007/s10577-018-9572-5 · Cited by 29

Functional roles of 3'-terminal structures of template RNA during in vivo retrotransposition of non-LTR retrotransposon, R1Bm

Anzai, T. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki347 · Cited by 27

The impact of transposable element activity on therapeutically relevant human stem cells

Schumann, G. G., Fuchs, N. V., Tristán-Ramos, P., Sebe, A., Ivics, Z., & Heras, S. R. (2019) · Mobile DNA · doi:10.1186/s13100-019-0151-x · Cited by 28

In Vitro Screening for Compounds That Enhance Human L1 Mobilization

Terasaki, N., Goodier, J. L., Cheung, L. E., Wang, Y. J., Kajikawa, M., Kazazian, H. H., & Okada, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074629 · Cited by 28

Detecting Alu insertions from high-throughput sequencing data

David, M., Mustafa, H., & Brudno, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt612 · Cited by 27

Sense transcripts originated from an internal part of the human retrotransposon LINE-1 5′ UTR

Alexandrova, E., Olovnikov, I. A., Malakhova, G., Zabolotneva, A. A., Suntsova, M., Dmitriev, S. E., & Buzdin, A. A. (2012) · Gene · doi:10.1016/j.gene.2012.09.026 · Cited by 25

Mercury specifically induces LINE-1 activity in a human neuroblastoma cell line

Habibi, L., Shokrgozar, M. A., Tabrizi, M. H., Modarressi, M. H., & Akrami, S. M. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.07.015 · Cited by 24

Genomic Landscape of Human, Bat, and Ex Vivo DNA Transposon Integrations

Campos-Sánchez, R., Kapusta, A., Feschotte, C., Chiaromonte, F., & Makova, K. D. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu138 · Cited by 25

L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins

Zhang, P., Ludwig, A. K., Hastert, F. D., Rausch, C., Lehmkuhl, A., Hellmann, I., Smets, M., Leonhardt, H., & Cardoso, M. C. (2017) · Nucleus · doi:10.1080/19491034.2017.1330238 · Cited by 25

Differential Effect of Selection against LINE Retrotransposons among Vertebrates Inferred from Whole-Genome Data and Demographic Modeling

Xue, A. T., Ruggiero, R. P., Hickerson, M. J., & Boissinot, S. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy083 · Cited by 27

Latent infection with Kaposi’s sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1

Nakayama, R., Ueno, Y., Ueda, K., & Honda, T. (2019) · Oncogene · doi:10.1038/s41388-019-0726-5 · Cited by 25

Similar Evolutionary Trajectories for Retrotransposon Accumulation in Mammals

Buckley, R. M., Kortschak, R. D., Raison, J. M., & Adelson, D. L. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx179 · Cited by 26

Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function

Adney, E. M., Ochmann, M. T., Sil, S., Truong, D. M., Mita, P., Wang, X., Kahler, D. J., Fenyö, D., Holt, L. J., & Boeke, J. D. (2019) · Genetics · doi:10.1534/genetics.119.302601 · Cited by 27

APOBEC3G Oligomerization Is Associated with the Inhibition of Both Alu and LINE-1 Retrotransposition

Koyama, T., Arias, J. F., Iwabu, Y., Yokoyama, M., Fujita, H., Sato, H., & Tokunaga, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084228 · Cited by 25

Mechanism by which a LINE protein recognizes its 3′ tail RNA

Hayashi, Y., Kajikawa, M., Matsumoto, T., & Okada, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku753 · Cited by 24

A computational reconstruction of Papio phylogeny using Alu insertion polymorphisms

Jordan, V. E., Walker, J. A., Beckstrom, T. O., Steely, C. J., McDaniel, C. L., Romain, C. P. S., Worley, K. C., Phillips‐Conroy, J. E., Jolly, C. J., Rogers, J., et al. (2018) · Mobile DNA · doi:10.1186/s13100-018-0118-3 · Cited by 24

Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells

Ward, J. R., Vasu, K., Deutschman, E., Halawani, D., Larson, P. A., Zhang, D., Willard, B. B., Fox, P. L., Moran, J. V., & Longworth, M. S. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007051 · Cited by 26

LINE-1 transposable element renaissance in aging and age-related diseases

Li, X., Yu, H., Li, D., & Liu, N. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102440 · Cited by 23

RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity

Ohshima, K. (2013) · International Journal of Evolutionary Biology · doi:10.1155/2013/424726 · Cited by 24

Restless Genomes

Hedges, D. J., & Belancio, V. P. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380860-8.00006-9 · Cited by 21

Protein Interactions Involved in tRNA Gene-Specific Integration of Dictyostelium discoideum Non-Long Terminal Repeat Retrotransposon TRE5-A

Chung, T., Siol, O., Dingermann, T., & Winckler, T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01173-07 · Cited by 24

Ionizing radiation and genetic risks. XVII. Formation mechanisms underlying naturally occurring DNA deletions in the human genome and their potential relevance for bridging the gap between induced DNA double-strand breaks and deletions in irradiated germ cells

Sankaranarayanan, K., Taleei, R., Rahmanian, S., & Nikjoo, H. (2013) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2013.07.003 · Cited by 24

How Chaotic Is Genome Chaos?

Shapiro, J. A. (2021) · Cancers · doi:10.3390/cancers13061358 · Cited by 21

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development

Bona, N., & Crossan, G. P. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01067-8 · Cited by 23

Retrotransposons and piRNA: The missing link in central nervous system

Rajan, K. S., & Ramasamy, S. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.05.017 · Cited by 22

Functional impact of the human mobilome

Babatz, T. D., & Burns, K. H. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.02.007 · Cited by 23

Long INterspersed element‐1 mobility as a sensor of environmental stresses

Re, B. D., & Giorgi, G. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22366 · Cited by 25

In vivo RNA localization of I factor, a non-LTR retrotransposon, requires a cis-acting signal in ORF2 and ORF1 protein

Seleme, M. D. C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki221 · Cited by 22

Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana

Pélissier, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh738 · Cited by 22

LINEs of evidence: noncanonical DNA replication as an epigenetic determinant

Belan, E. (2013) · Biology Direct · doi:10.1186/1745-6150-8-22 · Cited by 22

A neurodevelopmental disorder caused by a novel de novo SVA insertion in exon 13 of the SRCAP gene

Zhao, B., Madden, J. A., Lin, J., Berry, G. T., Wojcik, M. H., Zhao, X., Brand, H., Talkowski, M. E., Lee, E. A., & Agrawal, P. B. (2022) · European Journal of Human Genetics · doi:10.1038/s41431-022-01137-3 · Cited by 23

The Reverse Transcriptase Encoded by the Non-LTR Retrotransposon R2 Is as Error-Prone as That Encoded by HIV-1

Jamburuthugoda, V. K., & Eickbush, T. H. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.02.015 · Cited by 22

Skeletal muscle LINE-1 retrotransposon activity is upregulated in older versus younger rats

Mumford, P. W., Romero, M. A., Osburn, S. C., Roberson, P. A., Vann, C. G., Mobley, C. B., Brown, M. D., Kavazis, A. N., Young, K. C., & Roberts, M. D. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00110.2019 · Cited by 23

Molecular Reconstruction of Extinct LINE-1 Elements and Their Interaction with Nonautonomous Elements

Wagstaff, B. J., Kroutter, E. N., Derbes, R. S., Belancio, V. P., & Roy‐Engel, A. M. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss202 · Cited by 21

A bioinformatics search pipeline, RNA2DSearch, identifies RNA localization elements in Drosophila retrotransposons

Hamilton, R. S., Hartswood, E., Vendra, G., Jones, C., Bor, V. V. D., Finnegan, D., & Davis, I. (2009) · RNA · doi:10.1261/rna.1264109 · Cited by 21

Tandem insertions of Alu elements

El-Sawy, M., & Deininger, P. L. (2004) · Cytogenetic and Genome Research · doi:10.1159/000080802 · Cited by 21

Line-1: Implications in the etiology of cancer, clinical applications, and pharmacologic targets

Khalid, M., Bojang, P., Hassanin, A. A. I., Bowers, E. C., Reyes‐Reyes, E. M., Ramos, I. N., & Ramos, K. S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.09.003 · Cited by 21

Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis

Pfaff, A. L., Lopez, A. I., Iacoangeli, A., Bubb, V. J., Smith, B. N., Troakes, C., Alahmady, N. F., Kõks, S., Schumann, G. G., Al‐Chalabi, A., et al. (2020) · Molecular Brain · doi:10.1186/s13041-020-00694-2 · Cited by 21

Diversity-generating Retroelements in Phage and Bacterial Genomes

Guo, H., Arambula, L., Ghosh, P., & Miller, J. F. (2015) · ASM Press eBooks · doi:10.1128/9781555819217.ch53 · Cited by 20

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation

Arroyo, M. D. C. G., Hastert, F. D., Zhadan, A., Schelter, F., Zimbelmann, S., Rausch, C., Ludwig, A. K., Carell, T., & Cardoso, M. C. (2022) · Nature Communications · doi:10.1038/s41467-022-32799-8 · Cited by 19

Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response

Luca, C. D., Gupta, A. K., & Bortvin, A. L. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010797 · Cited by 25

Internal priming: An opportunistic pathway for L1 and Alu retrotransposition in hominins

Srikanta, D., Sen, S. K., Conlin, E. M., & Batzer, M. A. (2009) · Gene · doi:10.1016/j.gene.2009.05.014 · Cited by 20

Heritable L1 Retrotransposition Events During Development: Understanding Their Origins

Richardson, S. R., & Faulkner, G. J. (2018) · BioEssays · doi:10.1002/bies.201700189 · Cited by 20

Higher Rates of Processed Pseudogene Acquisition in Humans and Three Great Apes Revealed by Long-Read Assemblies

Feng, X., & Li, H. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab062 · Cited by 19

Conserved 3′ UTR stem-loop structure in L1 and Alu transposons in human genome: possible role in retrotransposition

Grechishnikova, D., & Poptsova, M. S. (2016) · BMC Genomics · doi:10.1186/s12864-016-3344-4 · Cited by 20

Characterization of reverse transcriptase activity of the L1Tc retroelement from Trypanosoma cruzi

Gonz�lez, C. I., Thomas, M. C., Olivares, M., L�pez, M. C., & Garc�a-P�rez, J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3342-y · Cited by 19

Development of a monoclonal antibody specific to the endonuclease domain of the human LINE-1 ORF2 protein

Sokolowski, M. J., DeFreece, C., Servant, G., Kines, K. J., deHaro, D. L., & Belancio, V. P. (2014) · Mobile DNA · doi:10.1186/s13100-014-0029-x · Cited by 19

Independently derived targeting of 28S rDNA by A- and D-clade R2 retrotransposons

Thompson, B. K., & Christensen, S. M. (2011) · Mobile Genetic Elements · doi:10.4161/mge.1.1.16485 · Cited by 19

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis

Wilkes, M. C., Repellin, C. E., & Sakamoto, K. M. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.07.008 · Cited by 20

Comparative analysis on the expression of L1 loci using various RNA-Seq preparations

Kaul, T. K., Morales, M. E., Sartor, A. O., Belancio, V. P., & Deininger, P. L. (2020) · Mobile DNA · doi:10.1186/s13100-019-0194-z · Cited by 20

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells

Schöbel, A., Nguyen-Dinh, V., Schumann, G. G., & Herker, E. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009496 · Cited by 19

Human Genomic Deletions Generated by SVA-Associated Events

Lee, J., Ha, J., Son, S.-Y., & Han, K. (2012) · Comparative and Functional Genomics · doi:10.1155/2012/807270 · Cited by 18

Advances in understanding the initiation of HIV-1 reverse transcription

Krupkin, M., Jackson, L. N., Ha, B., & Puglisi, E. V. (2020) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2020.07.005 · Cited by 19

Solution structure and functional importance of a conserved RNA hairpin of eel LINE UnaL2

Nomura, Y., Kajikawa, M., Baba, S., Nakazato, S., Imai, T., Sakamoto, T., Okada, N., & Kawai, G. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl664 · Cited by 18

Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells

Aschacher, T., Wolf, B., Aschacher, O., Enzmann, F., László, V., Meßner, B., Türkcan, A., Weis, S., Spiegl‐Kreinecker, S., Holzmann, K., et al. (2019) · Neoplasia · doi:10.1016/j.neo.2019.11.002 · Cited by 17

Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics

Ramos, K. S., Bojang, P., & Bowers, E. C. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211031247 · Cited by 19

Human LINE-1 retrotransposons: impacts on the genome and regulation by host factors

Luqman-Fatah, A., & Miyoshi, T. (2022) · Genes & Genetic Systems · doi:10.1266/ggs.22-00038 · Cited by 20

Retrotransposon life cycle and its impacts on cellular responses

Luqman-Fatah, A., Nishimori, K., Amano, S., Fumoto, Y., & Miyoshi, T. (2024) · RNA Biology · doi:10.1080/15476286.2024.2409607 · Cited by 20

DNA polymerization by the reverse transcriptase of the human L1 retrotransposon on its own template in vitro

Piskareva, O., & Schmatchenko, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.077 · Cited by 54

Template and target-site recognition by human LINE-1 in retrotransposition

Thawani, A., Ariza, A. J. F., Nogales, E., & Collins, K. (2023) · Nature · doi:10.1038/s41586-023-06933-5 · Cited by 82

L1 retrotransposition

Viollet, S., Monot, C., & Cristofari, G. (2014) · Mobile Genetic Elements · doi:10.4161/mge.28907 · Cited by 30

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139

Commentary

Elements, M. G., L, E. J., & Bioscience, E. (2016)