Human L1 element target‐primed reverse transcription in vitro

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

Origin and evolution of retroelements based upon their reverse transcriptase sequences

Xiong, Y., & Eickbush, T. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07536.x · Cited by 1,374

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

Luan, D. D., Korman, M. H., Jakubczak, J. L., & Eickbush, T. H. (1993) · Cell · doi:10.1016/0092-8674(93)90078-5 · Cited by 1,173

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139

[5] Synthesis of small RNAs using T7 RNA polymerase

Milligan, J. F., & Uhlenbeck, O. C. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(89)80091-6 · Cited by 1,071

High frequency retrotransposition in cultured mammalian cells

Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D., & Kazazian, H. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81998-4 · Cited by 1,022

Human LINE retrotransposons generate processed pseudogenes

Esnault, C., Maestre, J., & Heidmann, T. (2000) · Nature Genetics · doi:10.1038/74184 · Cited by 835

Biology of Mammalian L1 Retrotransposons

Ostertag, E. M., & Kazazian, H. H. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091032 · Cited by 782

Reverse Transcriptase Encoded by a Human Transposable Element

Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D., & Gabriel, A. (1991) · Science · doi:10.1126/science.1722352 · Cited by 774

Human L1 Retrotransposition: cis Preference versus trans Complementation

Wei, W., Gilbert, N., Ooi, S. L., Lawler, J. F., Ostertag, E. M., Kazazian, H. H., Boeke, J. D., & Moran, J. V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1429-1439.2001 · Cited by 637

Analysis of LINE-1 Expression in Human Pluripotent Cells

Muñoz-López, M., García-Cañadas, M., Macia, Á., Morell, S., & Garcia-Perez, J. L. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-794-1_7 · Cited by 17

A conserved role for the ESCRT membrane budding complex in LINE retrotransposition

Horn, A. V., Celic, I., Dong, C., Martirosyan, I. A., & Han, J. S. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006837 · Cited by 18

Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes

Levy, O., Knisbacher, B. A., Levanon, E. Y., & Havlin, S. (2017) · Science Advances · doi:10.1126/sciadv.1701256 · Cited by 17

Completion of LINE integration involves an open ‘4-way’ branched DNA intermediate

Khadgi, B. B., Govindaraju, A., & Christensen, S. M. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz673 · Cited by 17

Condensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1

Ward, J. R., Khan, A., Torres, S., Crawford, B., Nock, S. L., Frisbie, T. J., Moran, J. V., & Longworth, M. S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac802 · Cited by 15

Transposable elements and their potential role in complex lung disorder

Sargurupremraj, M., & Wjst, M. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-99 · Cited by 17

Spliced integrated retrotransposed element (SpIRE) formation in the human genome

Larson, P. A., Moldovan, J. B., Jasti, N., Kidd, J. M., Beck, C. R., & Moran, J. V. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003067 · Cited by 20

The Mobilome of Reptiles: Evolution, Structure, and Function

Boissinot, S., Bourgeois, Y., Manthey, J. D., & Ruggiero, R. P. (2019) · Cytogenetic and Genome Research · doi:10.1159/000496416 · Cited by 15

Transposable element-mediated structural variation analysis in dog breeds using whole-genome sequencing

Kim, S., Mun, S., Kim, T., Lee, K.-H., Kang, K., Cho, J., & Han, K. (2019) · Mammalian Genome · doi:10.1007/s00335-019-09812-5 · Cited by 17

Characterization of an active LINE-1 in the naked mole-rat genome

Yamaguchi, S., Nohara, S., Nishikawa, Y., Suzuki, Y., Kawamura, Y., Miura, K., Tomonaga, K., Ueda, K., & Honda, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-84962-8 · Cited by 16

A study of transposable element-associated structural variations (TASVs) using a de novo-assembled Korean genome

Mun, S., Kim, S., Lee, W., Kang, K., Meyer, T. J., Han, B., Han, K., & Kim, H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00586-y · Cited by 14

LEAP: L1 Element Amplification Protocol

Kopera, H. C., Flasch, D. A., Nakamura, M., Miyoshi, T., Doucet, A. J., & Moran, J. V. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3372-3_21 · Cited by 17

MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties

Liu, Q., Yi, D., Ding, J., Mao, Y., Wang, S., Ma, L., Li, Q., Wang, J., Zhang, Y., Zhao, J., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256512 · Cited by 18

Are non‐protein coding RNAs junk or treasure?

Walter, N. G. (2024) · BioEssays · doi:10.1002/bies.202300201 · Cited by 19

A high throughput screen for active human transposable elements

Kvikstad, E. M., Piazza, P., Taylor, J. C., & Lunter, G. A. (2018) · BMC Genomics · doi:10.1186/s12864-018-4485-4 · Cited by 15

Separable structural requirements for cDNA synthesis, nontemplated extension, and template jumping by a non-LTR retroelement reverse transcriptase

Pimentel, S. C., Upton, H. E., & Collins, K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101624 · Cited by 15

Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics

Wallace, N. A., Belancio, V. P., Faber, Z. J., & Deininger, P. L. (2010) · Mobile DNA · doi:10.1186/1759-8753-1-22 · Cited by 15

DNA cleavage and Trp53 differentially affect SINE transcription

Hagan, C. R., & Rudin, C. M. (2006) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20406 · Cited by 15

mRNA Retrotransposition Coupled with 5' Inversion as a Possible Source of New Genes

Kojima, K. K., & Okada, N. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp050 · Cited by 15

Maintenance of multiple lineages of R1 and R2 retrotransposable elements in the ribosomal RNA gene loci of Nasonia

Stage, D. E., & Eickbush, T. H. (2010) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2009.00949.x · Cited by 14

Analysis of western lowland gorilla (Gorilla gorilla gorilla) specific Alu repeats

McLain, A. T., Carman, G. W., Fullerton, M. L., Beckstrom, T. O., Gensler, W., Meyer, T. J., Faulk, C. D., & Batzer, M. A. (2013) · Mobile DNA · doi:10.1186/1759-8753-4-26 · Cited by 14

Self-Interaction, Nucleic Acid Binding, and Nucleic Acid Chaperone Activities Are Unexpectedly Retained in the Unique ORF1p of Zebrafish LINE

Nakamura, M., Okada, N., & Kajikawa, M. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06162-11 · Cited by 14

Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease

Miller, I. J., Totrov, M. M., Korotchkina, L. G., Kazyulkin, D. N., Gudkov, A. V., & Korolev, S. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab826 · Cited by 17

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

D’Ordine, A. M., Jogl, G., & Sedivy, J. M. (2024) · Nature Communications · doi:10.1038/s41467-024-48066-x · Cited by 15

Ancient Traces of Tailless Retropseudogenes in Therian Genomes

Noll, A., Raabe, C. A., Churakov, G., Brosius, J., & Schmitz, J. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv040 · Cited by 13

Discovery of short pseudogenes derived from messenger RNAs

Terai, G., Yoshizawa, A., Okida, H., Asai, K., & Mitsuyama, T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1098 · Cited by 13

Roles of retrotransposons in benign and malignant hematologic disease.

Schneider, A. M., Duffield, A. S., Symer, D. E., & Burns, K. H. (2009) · PubMed · Cited by 13

Endonuclease domain of non-LTR retrotransposons: loss-of-function mutants and modeling of the R2Bm endonuclease

Govindaraju, A., Cortez, J. D., Reveal, B., & Christensen, S. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw134 · Cited by 11

U-tail as a guardian against invading RNAs

Yeo, J., & Kim, V. N. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0139-0 · Cited by 12

Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition

Kuroki, R., Murata, Y., Fuke, S., Nakachi, Y., Nakashima, J., Kujoth, G. C., Prolla, T. A., Bundo, M., Kato, T., & Iwamoto, K. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.519206 · Cited by 11

Deep Sequencing Reveals Low Incidence of Endogenous LINE-1 Retrotransposition in Human Induced Pluripotent Stem Cells

Arokium, H., Kamata, M., Kim, S., Kim, N., Liang, M., Presson, A. P., & Chen, I. S. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108682 · Cited by 14

Effects of L1-ORF2 fragments on green fluorescent protein gene expression

Wang, X., Jin, X., Wang, X., Liu, J., Feng, J., Yang, Q., Mu, W., Shi, X., & Lu, Z. (2009) · Genetics and Molecular Biology · doi:10.1590/s1415-47572009005000068 · Cited by 12

Template jumping by a LINE reverse transcriptase has created a SINE-like 5S rRNA retropseudogene in Dictyostelium

Szafranski, K., Dingermann, T., Glöckner, G., & Winckler, T. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-003-0961-9 · Cited by 12

Functional splice sites in a zebrafish LINE and their influence on zebrafish gene expression

Tamura, M., Kajikawa, M., & Okada, N. (2006) · Gene · doi:10.1016/j.gene.2006.09.003 · Cited by 12

Haplotype-resolved inversion landscape reveals hotspots of mutational recurrence associated with genomic disordersPreprint

Porubskỳ, D., Höps, W., Ashraf, H., Hsieh, P., Rodríguez–Martín, B., Yilmaz, F., Ebler, J., Hallast, P., Maggiolini, F. A. M., Harvey, W. T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.20.472354 · Cited by 12

Distinct and overlapping RNA determinants for binding and target-primed reverse transcription by Bombyx mori R2 retrotransposon protein

Rodríguez-Vargas, A., & Collins, K. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae194 · Cited by 11

Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition

Schneider, A. M., Schmidt, S., Jonas, S., Vollmer, B., Khazina, E., & Weichenrieder, O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt786 · Cited by 11

Cross-Kingdom Commonality of a Novel Insertion Signature of RTE-Related Short Retroposons

Nishiyama, E., & Ohshima, K. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy098 · Cited by 11

Contribution and therapeutic implications of retroelement insertions in ataxia telangiectasia

Zhao, B., Nguyen, M. A., Woo, S., Kim, J., Yu, T. W., & Lee, E. A. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.09.008 · Cited by 11

Neisseria gonorrhoeae and humans perform an evolutionary LINE dance

Anderson, M. T., & Seifert, H. S. (2011) · Mobile Genetic Elements · doi:10.4161/mge.1.1.15868 · Cited by 11

Effect of Heavy Metals on Silencing of Engineered Long Interspersed Element-1 Retrotransposon Retrotransposon in Nondividing Neuroblastoma Cell Line

Habibi, L., Shokrgozar, M. A., Motamedi, M., & Akrami, S. M. (1996) · Europe PMC (PubMed Central) · doi:10.6091/ibj.1230.2013 · Cited by 13

Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

Briggs, E. M., Mita, P., Sun, X., Ha, S., Vasilyev, N., Leopold, Z., Nudler, E., Boeke, J. D., & Logan, S. K. (2021) · Mobile DNA · doi:10.1186/s13100-021-00249-9 · Cited by 13

A yeast model for target-primed (non-LTR) retrotransposition

Goodwin, T. J. D., Busby, J. N., & Poulter, R. T. M. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-263 · Cited by 11

Acquisition of Endonuclease Specificity during Evolution of L1 Retrotransposon

Ichiyanagi, K., Nishihara, H., Duvernell, D. D., & Okada, N. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm130 · Cited by 11

Probing the secondary structure of salmon SmaI SINE RNA

Kawagoe-Takaki, H., Nameki, N., Kajikawa, M., & Okada, N. (2005) · Gene · doi:10.1016/j.gene.2005.09.027 · Cited by 11

Processed pseudogene insertion in GLB1 causes Morquio B disease by altering intronic splicing regulatory landscape

Bychkov, I. O., Kuznetsova, A., Baydakova, G., Gorobets, L. V., Kenis, V. M., Dimitrieva, A. J., Filatova, A. Y., Tabakov, V. Y., Skoblov, M. Y., & Zakharova, E. Y. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00315-y · Cited by 11

The RNA editing enzyme ADAR2 restricts L1 mobility

Frassinelli, L., Orecchini, E., Alwardat, S., Tripodi, M., Mancone, C., Doria, M., Galardi, S., Ciafrè, S. A., & Michienzi, A. (2021) · RNA Biology · doi:10.1080/15476286.2021.1940020 · Cited by 10

The Regulation and Immune Signature of Retrotransposons in Cancer

Alkailani, M. I., & Gibbings, D. (2023) · Cancers · doi:10.3390/cancers15174340 · Cited by 10

Low dependency of retrotransposition on the ORF1 protein of the zebrafish LINE, ZfL2-1

Kajikawa, M., Sugano, T., Sakurai, R., & Okada, N. (2012) · Gene · doi:10.1016/j.gene.2012.02.048 · Cited by 10

Circular retrotransposition products generated by a LINE retrotransposon

Han, J. S., & Shao, S. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks859 · Cited by 10

Biology of Trypanosoma cruzi Retrotransposons: From an Enzymatic to a Structural Point of View

Macías, F. A., Afonso-Lehmann, R. N., López, M. C., Gómez, I., & Thomas, M. C. (2017) · Current Genomics · doi:10.2174/1389202918666170815150738 · Cited by 10

sRNA/L1 retrotransposition: using siRNAs and miRNAs to expand the applications of the cell culture-based LINE-1 retrotransposition assay

Tristán-Ramos, P., Morell, S., Sánchez, L., Toledo, B., Garcia-Perez, J. L., & Heras, S. R. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0346 · Cited by 11

MxB inhibits long interspersed element type 1 retrotransposition

Huang, Y., Xu, F., Mei, S., Liu, X., Zhao, F., Liang, W. P., Fan, Z., Hu, Y., Wang, L., Ai, B., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010034 · Cited by 9

The Impact of LINE-1 Retro transposition on the Human Genome

Hulme, A. E., Kulpa, D. A., Garcia-Perez, J. L., & Moran, J. V. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-039-3_3 · Cited by 10

Differential expressions of L1-chimeric transcripts in normal and matched-cancer tissues

Kim, S., Shin, W., Lee, Y., Mun, S., & Han, K. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113769 · Cited by 10

The 5′ truncation of retrotransposon L1: a process of genome integrity

Levin, H. L., Lee, S., & Anand, A. (2025) · Genetics · doi:10.1093/genetics/iyaf202 · Cited by 13

A genome-wide strategy to identify causes and consequences of retrotransposon expression finds activation by BRCA1 in ovarian cancer

Alkailani, M. I., Palidwor, G., Poulin, A., Mohan, R., Pépin, D., Vanderhyden, B. C., & Gibbings, D. (2021) · NAR Cancer · doi:10.1093/narcan/zcaa040 · Cited by 9

Identification of a family of SINEs and LINEs in the Pipistrellus kuhli genome: A new structural and functional symbiotic relationship

Fantaccione, S., Woodrow, P., & Pontecorvo, G. (2008) · Genomics · doi:10.1016/j.ygeno.2007.10.008 · Cited by 9

Target site analysis of RTE1_LA and its AfroSINE partner in the elephant genome

Gilbert, C., Pace, J. K., & Waters, P. D. (2008) · Gene · doi:10.1016/j.gene.2008.08.013 · Cited by 9

Genomic alterations upon integration of zebrafish L1 elements revealed by the TANT method

Ichiyanagi, K., & Okada, N. (2006) · Gene · doi:10.1016/j.gene.2006.07.038 · Cited by 10

Insights into the RNA binding mechanism of human L1-ORF1p: a molecular dynamics study

Rajagopalan, M., Balasubramanian, S., & Ramaswamy, A. (2017) · Molecular BioSystems · doi:10.1039/c7mb00358g · Cited by 9

Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells

McKerrow, W., Tang, Z., Steranka, J. P., Payer, L. M., Boeke, J. D., Keefe, D. L., Fenyö, D., Burns, K. H., & Liu, C. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0335 · Cited by 10

Targeting transposable elements in cancer: developments and opportunities

Wang, Z.-Y., Ge, L., Ouyang, Y., Jin, X., & Jiang, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189143 · Cited by 11

Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication

Hwang, S.-Y., Kim, H., Denisko, D., Zhao, B., Lee, D., Jeong, J., Kim, J., Park, K., Park, J., Jeong, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51961-y · Cited by 10

Retrotransposition-competent L1s are increased in the genomes of individuals with amyotrophic lateral sclerosis

Pfaff, A. L., & Kõks, S. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10575 · Cited by 8

Mechanism of DNA targeting by human LINE-1

Jin, W., Yu, C., Zhang, Y., Cao, C., Xia, T., Song, G., Cai, Z., Xue, Y., Zhu, B., & Xu, R.-M. (2025) · Science · doi:10.1126/science.adu3433 · Cited by 9

Molecular Mechanisms of Alu and LINE-1 Interspersed Repetitive Sequences Reveal Diseases of Visual System Dysfunction

Khan, M., Shah, S., Lv, B., Lv, Z., Ji, N., Song, Z., Wu, P., Wang, X., & Mehmood, A. (2022) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2022.2112238 · Cited by 8

The Molecular Impacts of Retrotransposons in Development and Diseases

Tam, P. L. F., & Leung, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216418 · Cited by 11

Conformational analysis on the wild type and mutated forms of human ORF1p: a molecular dynamics study

Rajagopalan, M., Balasubramanian, S., & Ramaswamy, A. (2015) · Molecular BioSystems · doi:10.1039/c5mb00194c · Cited by 8

The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni

Liu, G., Jiang, H., Sun, W., Zhang, J., Chen, D., & Murchie, A. I. H. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab818 · Cited by 8

Links Between Repeated Sequences

Matsutani, S. (2006) · BioMed Research International · doi:10.1155/jbb/2006/13569 · Cited by 9

Targeted insertion of large genetic payloads using cas directed LINE-1 reverse transcriptase

Manoj, F., Tai, L. W., Wang, K. S. M., & Kuhlman, T. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-03130-0 · Cited by 7

Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome

Siol, O., Spaller, T., Schiefner, J., & Winckler, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr261 · Cited by 8

A new mechanism to ensure integration during LINE retrotransposition: A suggestion from analyses of the 5′ extra nucleotides

Kajikawa, M., YAMAGUCHI, K., & Okada, N. (2012) · Gene · doi:10.1016/j.gene.2012.02.047 · Cited by 7

Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain

Moszczyńska, A. (2020) · Genes · doi:10.3390/genes11040364 · Cited by 8

Reverse Transcriptases

Grice, S. F. J. L., & Nowotny, M. (2013) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-39796-7_8 · Cited by 7

Correction: An Alu-Based Phylogeny of Lemurs (Infraorder: Lemuriformes)

McLain, A. T., Meyer, T. J., Faulk, C. D., Herke, S. W., Oldenburg, J. M., Bourgeois, M. G., Abshire, C. F., Roos, C., & Batzer, M. A. (2012) · PLoS ONE · doi:10.1371/annotation/378aaec2-599e-4cd4-8941-3a14c208b757 · Cited by 7

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesisPreprint

Zumalave, S., Santamarina, M., Espasandín, N. P., García‐Souto, D., Temes, J., Baker, T. M., Pequeño‐Valtierra, A., Otero, I., Rodríguez‐Castro, J., Oitabén, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.27.596794 · Cited by 8

Structure characteristics of mutation sites in two waxy alleles from Yunnan waxy maize (Zea mays L. var. certaina Kulesh) landraces

Sun, T., & Wu, X. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291116 · Cited by 6

Exploring transposable elements: new horizons in cancer diagnostics and therapeutics

Chaaban, A., Sleem, R., Santina, J., Rima, M., & Ibrahim, J.-N. (2025) · Mobile DNA · doi:10.1186/s13100-025-00366-9 · Cited by 9

Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches

Miller, B. D., Smail, B. A., van Eeuwen, T., Kodama, H. M., Kondo, K., Jiang, H. L., O’Brien, A., Dai, N., Trachman, R. J., Guan, S., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110994 · Cited by 8

Intragenic L1 Insertion: One Possibility of Brain Disorder

Son, J.-H., Do, H., & Han, J. (2022) · Life · doi:10.3390/life12091425 · Cited by 6

Interactions of Transposons with the Cellular DNA Repair Machinery

Izsvák, Z., Wang, Y., & Ivics, Z. (2009) · Genome dynamics and stability · doi:10.1007/7050_2008_043 · Cited by 6

The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury

Ramos, K. S., Teneng, I., Montoya-Durango, D. E., Bojang, P., Haeberle, M. T., Ramos, I. N., Stribinskis, V., & Kalbfleisch, T. (2013) · Epigenetics and human health · doi:10.1007/978-3-642-23380-7_6 · Cited by 6

The C-Module-Binding Factor Supports Amplification of TRE5-A Retrotransposons in the Dictyostelium discoideum Genome

Bilzer, A., Dölz, H., Reinhardt, A., Schmith, A., Siol, O., & Winckler, T. (2010) · Eukaryotic Cell · doi:10.1128/ec.00205-10 · Cited by 6

Role of transposable elements in the genome of Drosophila melanogaster

Vasileva, L. A., Antonenko, O. V., & Захаров, И. К. (2011) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059711060128 · Cited by 6

Integrated mechanism for the generation of the 5′ junctions of LINE inserts

YAMAGUCHI, K., Kajikawa, M., & Okada, N. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv041 · Cited by 6

Good, Bad, Mobile Elements: Genome's Most Successful “Parasites” as Emerging Players in Cell and Organismal Aging

Cardelli, M., & Marchegiani, F. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319090021 · Cited by 7

Variation in base composition underlies functional and evolutionary divergence in non-LTR retrotransposons

Ruggiero, R. P., & Boissinot, S. (2020) · Mobile DNA · doi:10.1186/s13100-020-00209-9 · Cited by 9

HIV suppressors against LINE-1: one functions as two

Du, J., & Zhao, K. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1893640 · Cited by 6

A new system for analyzing LINE retrotransposition in the chicken DT40 cell line widely used for reverse genetics

Honda, H., Ichiyanagi, K., Suzuki, J., Ono, T., Koyama, H., Kajikawa, M., & Okada, N. (2007) · Gene · doi:10.1016/j.gene.2007.02.017 · Cited by 6

18 SINEs and LINEs: Troublemakers, Saboteurs, Benefactors, AncestorsPreprint

Weiner, A. M. (2006) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969739.43.507 · Cited by 6

Inverted Alu repeats in loop-out exon skipping across hominoid evolution

Denisko, D., Kim, J., Ku, J., Zhao, B., & Lee, E. A. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag196 · Cited by 6

LINE retrotransposition and host DNA repair machinery

YAMAGUCHI, K., Kajikawa, M., & Okada, N. (2015) · Mobile Genetic Elements · doi:10.1080/2159256x.2015.1096998 · Cited by 5

A re-evaluation of LINE-1 ORF2 expression in LNCaP prostate cancer cells

Briggs, E. M., Spadafora, C., & Logan, S. K. (2019) · Mobile DNA · doi:10.1186/s13100-019-0196-x · Cited by 5

Retrotransposons: Genomic and Trans-Genomic Agents of Change

Adelson, D. L., Buckley, R. M., Ivancevic, A. M., Qu, Z., & Zeng, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-19932-0_4 · Cited by 5

Structural dynamics of wild type and mutated forms of human L1 endonuclease and insights into its sequence specific nucleic acid binding mechanism: A molecular dynamics study

Rajagopalan, M., Balasubramanian, S., & Ramaswamy, A. (2017) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2017.07.002 · Cited by 5

Retrotransposition disrupting EBP in a girl and her mother with X-linked dominant chondrodysplasia punctata

Hiraide, T., Masunaga, Y., Honda, A., Kato, F., Fukuda, T., Fukami, M., Nakashima, M., Saitsu, H., & Ogata, T. (2022) · Journal of Human Genetics · doi:10.1038/s10038-021-01000-1 · Cited by 5

Integrated mechanism for the generation of the 5′ junctions of LINE inserts

YAMAGUCHI, K., Kajikawa, M., & Okada, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1067 · Cited by 5

Pivotal Impacts of Retrotransposon Based Invasive RNAs on Evolution

Habibi, L., & Salmani, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01957 · Cited by 5

DNA polymerization by the reverse transcriptase of the human L1 retrotransposon on its own template in vitro

Piskareva, O., & Schmatchenko, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.077 · Cited by 54

Template and target-site recognition by human LINE-1 in retrotransposition

Thawani, A., Ariza, A. J. F., Nogales, E., & Collins, K. (2023) · Nature · doi:10.1038/s41586-023-06933-5 · Cited by 82

L1 retrotransposition

Viollet, S., Monot, C., & Cristofari, G. (2014) · Mobile Genetic Elements · doi:10.4161/mge.28907 · Cited by 30

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139

Commentary

Elements, M. G., L, E. J., & Bioscience, E. (2016)