Boeke, Jef D.

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 4,316

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 3,953

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,255

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 1,139

High frequency retrotransposition in cultured mammalian cells

Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D., & Kazazian, H. H. (1996) · Cell

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 1,022

The biochemistry of sirtuins

Sauve, A. A., Wolberger, C., Schramm, V. L., & Boeke, J. D. (2006) · Annual Review of Biochemistry

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 763

A phylogenetically conserved NAD + -dependent protein deacetylase activity in the Sir2 protein family

Smith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., et al. (2000) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineNuclear Structure and Function

Cited by 718

Lysine succinylation and lysine malonylation in histones

Xie, Z., Dai, J., Dai, L., Tan, M., Cheng, Z., Wu, Y., Boeke, J. D., & Zhao, Y. (2012) · Molecular & Cellular Proteomics

Genomics and Chromatin DynamicsAdvanced Proteomics Techniques and Applications

Cited by 613

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

Starai, V. J., Celic, I., Cole, R. N., Boeke, J. D., & Escalante-Semerena, J. C. (2002) · Science

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 564

Human L1 element target‐primed reverse transcription in vitro

Cost, G. J., Feng, Q., Jacquier, A., & Boeke, J. D. (2002) · The EMBO Journal

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 519

Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes

Han, J. S., Szak, S. T., & Boeke, J. D. (2004) · Nature

Chromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Cited by 484

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 446

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D. (2006) · Molecular Cell

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 438

“Perfect” designer chromosome V and behavior of a ring derivative.

Xie, Z.-X., Li, B.-Z., Mitchell, L. A., Wu, Y., Qi, X., Jin, Z., Jia, B., Wang, X., Zeng, B.-X., Liu, H.-M., et al. (2017) · Science

Fungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction

Cited by 255

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 233

Molecular archeology of L1 insertions in the human genome

Szak, S. T., Pickeral, O. K., Makalowski, W., Boguski, M. S., Landsman, D., & Boeke, J. D. (2002) · Genome Biology

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 230

Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome.

Shen, Y., Wang, Y., Chen, T., Gao, F., Gong, J., Abramczyk, D., Walker, R., Zhao, H., Chen, S., Liu, W., et al. (2017) · Science

Fungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction

Cited by 202

Super-enhancers include classical enhancers and facilitators to fully activate gene expression

Blayney, J. W., Francis, H., Rampasekova, A., Camellato, B., Mitchell, L., Stolper, R., Cornell, L., Babbs, C., Boeke, J. D., Higgs, D. R., et al. (2023) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 196

LINE-1 protein localization and functional dynamics during the cell cycle

Mita, P., Wudzinska, A., Sun, X., Andrade, J., Nayak, S., Kahler, D. J., Badri, S., LaCava, J., Ueberheide, B., Yun, C. Y., et al. (2018) · eLife

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 142

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Ardeljan, D., Steranka, J. P., Liu, C., Li, Z., Taylor, M. S., Payer, L. M., Gorbounov, M., Sarnecki, J. S., Deshpande, V., Hruban, R. H., et al. (2020) · Nature Structural & Molecular Biology

Chromosomal and Genetic VariationsDNA Repair Mechanisms

Cited by 135

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition

Dai, L., Huang, Q., & Boeke, J. D. (2011) · BMC Biochemistry

Chromosomal and Genetic VariationsHIV/AIDS drug development and treatment

Cited by 131

BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells

Mita, P., Sun, X., Fenyö, D., Kahler, D. J., Li, D., Agmon, N., Wudzinska, A., Keegan, S., Bader, J. S., Yun, C., et al. (2020) · Nature Structural & Molecular Biology

DNA Repair MechanismsChromosomal and Genetic Variations

Cited by 113

Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

Xie, Y., Rosser, J. M., Thompson, T. L., Boeke, J. D., & An, W. (2011) · Nucleic Acids Research

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 98

Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

An, W., Dai, L., Niewiadomska, A. M., Yetil, A., O'Donnell, K. A., Han, J. S., & Boeke, J. D. (2011) · Mobile DNA

Chromosomal and Genetic VariationsCRISPR and Genetic Engineering

Cited by 67